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Gene: NUDT15 |
Gene summary for NUDT15 |
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Gene information | Species | Human | Gene symbol | NUDT15 | Gene ID | 55270 |
Gene name | nudix hydrolase 15 | |
Gene Alias | MTH2 | |
Cytomap | 13q14.2 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q9NV35 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55270 | NUDT15 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.09e-02 | 1.92e-01 | -0.0811 |
55270 | NUDT15 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.03e-06 | 2.49e-01 | -0.1088 |
55270 | NUDT15 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.65e-12 | 3.20e-01 | -0.1954 |
55270 | NUDT15 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.73e-08 | 3.31e-01 | -0.1526 |
55270 | NUDT15 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.75e-05 | 2.34e-01 | -0.1464 |
55270 | NUDT15 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.65e-05 | 2.52e-01 | -0.059 |
55270 | NUDT15 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.11e-02 | 2.42e-01 | -0.0179 |
55270 | NUDT15 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.25e-09 | 2.99e-01 | 0.294 |
55270 | NUDT15 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.60e-19 | 7.37e-01 | 0.281 |
55270 | NUDT15 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.39e-16 | 4.07e-01 | 0.3859 |
55270 | NUDT15 | LZE4T | Human | Esophagus | ESCC | 2.97e-03 | 4.65e-02 | 0.0811 |
55270 | NUDT15 | LZE5T | Human | Esophagus | ESCC | 2.02e-02 | 2.16e-01 | 0.0514 |
55270 | NUDT15 | LZE7T | Human | Esophagus | ESCC | 1.11e-02 | 1.55e-01 | 0.0667 |
55270 | NUDT15 | LZE8T | Human | Esophagus | ESCC | 1.75e-02 | 1.60e-01 | 0.067 |
55270 | NUDT15 | LZE20T | Human | Esophagus | ESCC | 2.60e-07 | 1.46e-01 | 0.0662 |
55270 | NUDT15 | LZE22D1 | Human | Esophagus | HGIN | 3.43e-02 | 3.56e-02 | 0.0595 |
55270 | NUDT15 | LZE24T | Human | Esophagus | ESCC | 9.30e-03 | 2.02e-01 | 0.0596 |
55270 | NUDT15 | P2T-E | Human | Esophagus | ESCC | 9.16e-20 | 4.81e-01 | 0.1177 |
55270 | NUDT15 | P4T-E | Human | Esophagus | ESCC | 1.60e-07 | 2.17e-01 | 0.1323 |
55270 | NUDT15 | P5T-E | Human | Esophagus | ESCC | 1.88e-08 | 1.74e-01 | 0.1327 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031668 | Colorectum | AD | cellular response to extracellular stimulus | 71/3918 | 246/18723 | 1.86e-03 | 1.52e-02 | 71 |
GO:0006195 | Colorectum | AD | purine nucleotide catabolic process | 18/3918 | 46/18723 | 3.67e-03 | 2.60e-02 | 18 |
GO:0072523 | Colorectum | AD | purine-containing compound catabolic process | 19/3918 | 52/18723 | 6.92e-03 | 4.26e-02 | 19 |
GO:00421761 | Colorectum | SER | regulation of protein catabolic process | 126/2897 | 391/18723 | 5.33e-17 | 2.52e-14 | 126 |
GO:19033621 | Colorectum | SER | regulation of cellular protein catabolic process | 91/2897 | 255/18723 | 1.22e-15 | 5.36e-13 | 91 |
GO:19030501 | Colorectum | SER | regulation of proteolysis involved in cellular protein catabolic process | 77/2897 | 221/18723 | 7.85e-13 | 2.00e-10 | 77 |
GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
GO:00061631 | Colorectum | SER | purine nucleotide metabolic process | 109/2897 | 396/18723 | 4.26e-10 | 5.44e-08 | 109 |
GO:00725211 | Colorectum | SER | purine-containing compound metabolic process | 113/2897 | 416/18723 | 4.80e-10 | 5.68e-08 | 113 |
GO:00091441 | Colorectum | SER | purine nucleoside triphosphate metabolic process | 38/2897 | 88/18723 | 4.82e-10 | 5.68e-08 | 38 |
GO:00611361 | Colorectum | SER | regulation of proteasomal protein catabolic process | 62/2897 | 187/18723 | 1.28e-09 | 1.31e-07 | 62 |
GO:00069791 | Colorectum | SER | response to oxidative stress | 114/2897 | 446/18723 | 1.75e-08 | 1.28e-06 | 114 |
GO:00091171 | Colorectum | SER | nucleotide metabolic process | 122/2897 | 489/18723 | 2.50e-08 | 1.76e-06 | 122 |
GO:00091411 | Colorectum | SER | nucleoside triphosphate metabolic process | 41/2897 | 112/18723 | 3.46e-08 | 2.31e-06 | 41 |
GO:00067531 | Colorectum | SER | nucleoside phosphate metabolic process | 122/2897 | 497/18723 | 6.64e-08 | 4.33e-06 | 122 |
GO:00003021 | Colorectum | SER | response to reactive oxygen species | 65/2897 | 222/18723 | 1.21e-07 | 7.29e-06 | 65 |
GO:00442701 | Colorectum | SER | cellular nitrogen compound catabolic process | 99/2897 | 451/18723 | 1.46e-04 | 2.86e-03 | 99 |
GO:00467001 | Colorectum | SER | heterocycle catabolic process | 97/2897 | 445/18723 | 2.20e-04 | 3.89e-03 | 97 |
GO:19013611 | Colorectum | SER | organic cyclic compound catabolic process | 104/2897 | 495/18723 | 5.46e-04 | 7.63e-03 | 104 |
GO:00346551 | Colorectum | SER | nucleobase-containing compound catabolic process | 88/2897 | 407/18723 | 5.53e-04 | 7.71e-03 | 88 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUDT15 | SNV | Missense_Mutation | novel | c.99N>T | p.Lys33Asn | p.K33N | Q9NV35 | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-EW-A3E8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
NUDT15 | SNV | Missense_Mutation | rs773719265 | c.248C>A | p.Ser83Tyr | p.S83Y | Q9NV35 | protein_coding | deleterious(0.01) | possibly_damaging(0.744) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NUDT15 | SNV | Missense_Mutation | c.274N>G | p.Tyr92Asp | p.Y92D | Q9NV35 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
NUDT15 | SNV | Missense_Mutation | rs773719265 | c.248C>A | p.Ser83Tyr | p.S83Y | Q9NV35 | protein_coding | deleterious(0.01) | possibly_damaging(0.744) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NUDT15 | SNV | Missense_Mutation | rs773719265 | c.248N>A | p.Ser83Tyr | p.S83Y | Q9NV35 | protein_coding | deleterious(0.01) | possibly_damaging(0.744) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
NUDT15 | SNV | Missense_Mutation | rs773719265 | c.248C>A | p.Ser83Tyr | p.S83Y | Q9NV35 | protein_coding | deleterious(0.01) | possibly_damaging(0.744) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NUDT15 | SNV | Missense_Mutation | c.443C>A | p.Pro148Gln | p.P148Q | Q9NV35 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NUDT15 | SNV | Missense_Mutation | c.330N>T | p.Lys110Asn | p.K110N | Q9NV35 | protein_coding | tolerated(0.1) | benign(0.295) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
NUDT15 | SNV | Missense_Mutation | rs773719265 | c.248N>A | p.Ser83Tyr | p.S83Y | Q9NV35 | protein_coding | deleterious(0.01) | possibly_damaging(0.744) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUDT15 | SNV | Missense_Mutation | c.291G>A | p.Met97Ile | p.M97I | Q9NV35 | protein_coding | deleterious(0.03) | possibly_damaging(0.505) | TCGA-FI-A2EW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55270 | NUDT15 | ENZYME, CLINICALLY ACTIONABLE | Mercaptopurine | MERCAPTOPURINE | ||
55270 | NUDT15 | ENZYME, CLINICALLY ACTIONABLE | AZATHIOPRINE | AZATHIOPRINE | 26878724 | |
55270 | NUDT15 | ENZYME, CLINICALLY ACTIONABLE | Thioguanine | THIOGUANINE | ||
55270 | NUDT15 | ENZYME, CLINICALLY ACTIONABLE | mercaptopurine | MERCAPTOPURINE | 27530327,26503813,28146264,27558924,29967377,30035323,29923122,28659275,27381176,26590936,27193222,26878724,30048756,28445187,26033531,27416873,26076924,27604507,26735160,27577869,30101994,27095468 | |
55270 | NUDT15 | ENZYME, CLINICALLY ACTIONABLE | MERCAPTOPURINE | MERCAPTOPURINE | 26878724 | |
55270 | NUDT15 | ENZYME, CLINICALLY ACTIONABLE | azathioprine | AZATHIOPRINE | 27530327,26503813,28146264,27558924,30035323,25108385,29923122,27381176,26590936,27193222,30048756,26033531,27416873,26076924,27604507,26735160,27577869,30101994,27095468 | |
55270 | NUDT15 | ENZYME, CLINICALLY ACTIONABLE | thioguanine | THIOGUANINE | 27530327 | |
55270 | NUDT15 | ENZYME, CLINICALLY ACTIONABLE | THIOGUANINE | THIOGUANINE | 26878724 | |
55270 | NUDT15 | ENZYME, CLINICALLY ACTIONABLE | Azathioprine | AZATHIOPRINE |
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