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Gene: NDUFA5 |
Gene summary for NDUFA5 |
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Gene information | Species | Human | Gene symbol | NDUFA5 | Gene ID | 4698 |
Gene name | NADH:ubiquinone oxidoreductase subunit A5 | |
Gene Alias | B13 | |
Cytomap | 7q31.32 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | A0A087X1G1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4698 | NDUFA5 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.41e-03 | 3.73e-01 | -0.1088 |
4698 | NDUFA5 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.66e-07 | 4.31e-01 | -0.1954 |
4698 | NDUFA5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.77e-02 | 2.97e-01 | 0.294 |
4698 | NDUFA5 | A015-C-203 | Human | Colorectum | FAP | 1.59e-07 | -2.10e-01 | -0.1294 |
4698 | NDUFA5 | A002-C-201 | Human | Colorectum | FAP | 1.24e-02 | -1.46e-01 | 0.0324 |
4698 | NDUFA5 | A001-C-119 | Human | Colorectum | FAP | 8.39e-03 | -2.14e-01 | -0.1557 |
4698 | NDUFA5 | A001-C-108 | Human | Colorectum | FAP | 5.11e-04 | -1.64e-01 | -0.0272 |
4698 | NDUFA5 | A002-C-205 | Human | Colorectum | FAP | 8.23e-07 | -2.25e-01 | -0.1236 |
4698 | NDUFA5 | A001-C-104 | Human | Colorectum | FAP | 1.65e-03 | -1.70e-01 | 0.0184 |
4698 | NDUFA5 | A015-C-006 | Human | Colorectum | FAP | 1.97e-03 | -2.18e-01 | -0.0994 |
4698 | NDUFA5 | A015-C-106 | Human | Colorectum | FAP | 6.30e-06 | -1.62e-01 | -0.0511 |
4698 | NDUFA5 | A002-C-114 | Human | Colorectum | FAP | 4.36e-03 | -1.75e-01 | -0.1561 |
4698 | NDUFA5 | A015-C-104 | Human | Colorectum | FAP | 1.26e-06 | -1.65e-01 | -0.1899 |
4698 | NDUFA5 | A001-C-014 | Human | Colorectum | FAP | 1.87e-04 | -1.74e-01 | 0.0135 |
4698 | NDUFA5 | A002-C-016 | Human | Colorectum | FAP | 1.34e-03 | -1.76e-01 | 0.0521 |
4698 | NDUFA5 | A015-C-002 | Human | Colorectum | FAP | 4.57e-04 | -2.40e-01 | -0.0763 |
4698 | NDUFA5 | A001-C-203 | Human | Colorectum | FAP | 1.42e-03 | -1.40e-01 | -0.0481 |
4698 | NDUFA5 | A002-C-116 | Human | Colorectum | FAP | 1.15e-08 | -1.66e-01 | -0.0452 |
4698 | NDUFA5 | A014-C-008 | Human | Colorectum | FAP | 8.01e-03 | -2.19e-01 | -0.191 |
4698 | NDUFA5 | A018-E-020 | Human | Colorectum | FAP | 6.73e-05 | -2.08e-01 | -0.2034 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00061192 | Colorectum | MSS | oxidative phosphorylation | 76/3467 | 141/18723 | 3.49e-21 | 3.11e-18 | 76 |
GO:00229002 | Colorectum | MSS | electron transport chain | 83/3467 | 175/18723 | 2.06e-18 | 1.17e-15 | 83 |
GO:00229042 | Colorectum | MSS | respiratory electron transport chain | 61/3467 | 114/18723 | 4.46e-17 | 1.99e-14 | 61 |
GO:00427732 | Colorectum | MSS | ATP synthesis coupled electron transport | 54/3467 | 95/18723 | 8.09e-17 | 3.16e-14 | 54 |
GO:00427752 | Colorectum | MSS | mitochondrial ATP synthesis coupled electron transport | 54/3467 | 95/18723 | 8.09e-17 | 3.16e-14 | 54 |
GO:00196462 | Colorectum | MSS | aerobic electron transport chain | 51/3467 | 87/18723 | 9.74e-17 | 3.57e-14 | 51 |
GO:00061202 | Colorectum | MSS | mitochondrial electron transport, NADH to ubiquinone | 31/3467 | 51/18723 | 2.73e-11 | 3.67e-09 | 31 |
GO:00102572 | Colorectum | MSS | NADH dehydrogenase complex assembly | 33/3467 | 57/18723 | 4.07e-11 | 4.86e-09 | 33 |
GO:00329812 | Colorectum | MSS | mitochondrial respiratory chain complex I assembly | 33/3467 | 57/18723 | 4.07e-11 | 4.86e-09 | 33 |
GO:00331082 | Colorectum | MSS | mitochondrial respiratory chain complex assembly | 44/3467 | 93/18723 | 2.17e-10 | 2.09e-08 | 44 |
GO:00460344 | Colorectum | FAP | ATP metabolic process | 87/2622 | 277/18723 | 6.50e-14 | 6.63e-11 | 87 |
GO:00060914 | Colorectum | FAP | generation of precursor metabolites and energy | 128/2622 | 490/18723 | 5.58e-13 | 4.28e-10 | 128 |
GO:00159804 | Colorectum | FAP | energy derivation by oxidation of organic compounds | 85/2622 | 318/18723 | 1.36e-09 | 2.77e-07 | 85 |
GO:00090604 | Colorectum | FAP | aerobic respiration | 57/2622 | 189/18723 | 7.02e-09 | 1.02e-06 | 57 |
GO:00453334 | Colorectum | FAP | cellular respiration | 65/2622 | 230/18723 | 1.13e-08 | 1.33e-06 | 65 |
GO:00229004 | Colorectum | FAP | electron transport chain | 51/2622 | 175/18723 | 1.44e-07 | 9.03e-06 | 51 |
GO:00061194 | Colorectum | FAP | oxidative phosphorylation | 43/2622 | 141/18723 | 3.39e-07 | 1.86e-05 | 43 |
GO:00229044 | Colorectum | FAP | respiratory electron transport chain | 35/2622 | 114/18723 | 3.43e-06 | 1.23e-04 | 35 |
GO:00427734 | Colorectum | FAP | ATP synthesis coupled electron transport | 28/2622 | 95/18723 | 7.10e-05 | 1.32e-03 | 28 |
GO:00427754 | Colorectum | FAP | mitochondrial ATP synthesis coupled electron transport | 28/2622 | 95/18723 | 7.10e-05 | 1.32e-03 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05012 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa05208 | Colorectum | AD | Chemical carcinogenesis - reactive oxygen species | 126/2092 | 223/8465 | 1.01e-24 | 1.68e-22 | 1.07e-22 | 126 |
hsa00190 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa05415 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa05016 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa04932 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa05020 | Colorectum | AD | Prion disease | 133/2092 | 273/8465 | 2.47e-18 | 8.29e-17 | 5.29e-17 | 133 |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa04723 | Colorectum | AD | Retrograde endocannabinoid signaling | 59/2092 | 148/8465 | 2.94e-05 | 2.73e-04 | 1.74e-04 | 59 |
hsa050121 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa052081 | Colorectum | AD | Chemical carcinogenesis - reactive oxygen species | 126/2092 | 223/8465 | 1.01e-24 | 1.68e-22 | 1.07e-22 | 126 |
hsa001901 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa054151 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa049321 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDUFA5 | SNV | Missense_Mutation | c.314A>G | p.Glu105Gly | p.E105G | Q16718 | protein_coding | tolerated(0.1) | benign(0.127) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD | |
NDUFA5 | deletion | Frame_Shift_Del | c.122delN | p.Asn41MetfsTer28 | p.N41Mfs*28 | Q16718 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
NDUFA5 | SNV | Missense_Mutation | novel | c.320C>T | p.Pro107Leu | p.P107L | Q16718 | protein_coding | deleterious(0.04) | benign(0.111) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NDUFA5 | SNV | Missense_Mutation | novel | c.320N>T | p.Pro107Leu | p.P107L | Q16718 | protein_coding | deleterious(0.04) | benign(0.111) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NDUFA5 | SNV | Missense_Mutation | novel | c.134N>T | p.Arg45Ile | p.R45I | Q16718 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFA5 | SNV | Missense_Mutation | novel | c.212N>G | p.Gln71Arg | p.Q71R | Q16718 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NDUFA5 | SNV | Missense_Mutation | novel | c.90N>T | p.Lys30Asn | p.K30N | Q16718 | protein_coding | deleterious(0.02) | benign(0.208) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFA5 | SNV | Missense_Mutation | c.28N>T | p.Gly10Cys | p.G10C | Q16718 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-CC-A3MC-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
NDUFA5 | SNV | Missense_Mutation | novel | c.149A>T | p.Gln50Leu | p.Q50L | Q16718 | protein_coding | deleterious(0.04) | possibly_damaging(0.735) | TCGA-DD-AACL-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NDUFA5 | SNV | Missense_Mutation | novel | c.282G>A | p.Met94Ile | p.M94I | Q16718 | protein_coding | tolerated(0.1) | benign(0.14) | TCGA-78-7156-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4698 | NDUFA5 | ENZYME | inhibitor | CHEMBL3545320 | ME-344 | |
4698 | NDUFA5 | ENZYME | inhibitor | CHEMBL1703 | METFORMIN HYDROCHLORIDE | |
4698 | NDUFA5 | ENZYME | inhibitor | CHEMBL3545135 | NV-128 |
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