|
Gene: NDRG2 |
Gene summary for NDRG2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NDRG2 | Gene ID | 57447 |
Gene name | NDRG family member 2 | |
Gene Alias | SYLD | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9UN36 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57447 | NDRG2 | GSM4909281 | Human | Breast | IDC | 6.78e-03 | -5.82e-02 | 0.21 |
57447 | NDRG2 | GSM4909285 | Human | Breast | IDC | 2.15e-11 | 6.19e-03 | 0.21 |
57447 | NDRG2 | GSM4909286 | Human | Breast | IDC | 9.30e-11 | 1.88e-01 | 0.1081 |
57447 | NDRG2 | GSM4909287 | Human | Breast | IDC | 5.26e-07 | -4.83e-01 | 0.2057 |
57447 | NDRG2 | GSM4909290 | Human | Breast | IDC | 4.01e-23 | -7.95e-01 | 0.2096 |
57447 | NDRG2 | GSM4909291 | Human | Breast | IDC | 2.11e-19 | -8.05e-01 | 0.1753 |
57447 | NDRG2 | GSM4909292 | Human | Breast | IDC | 2.43e-05 | -8.50e-01 | 0.1236 |
57447 | NDRG2 | GSM4909293 | Human | Breast | IDC | 9.69e-14 | -6.57e-01 | 0.1581 |
57447 | NDRG2 | GSM4909294 | Human | Breast | IDC | 1.39e-24 | -6.76e-01 | 0.2022 |
57447 | NDRG2 | GSM4909296 | Human | Breast | IDC | 4.37e-24 | -7.69e-01 | 0.1524 |
57447 | NDRG2 | GSM4909297 | Human | Breast | IDC | 3.11e-27 | -6.91e-01 | 0.1517 |
57447 | NDRG2 | GSM4909298 | Human | Breast | IDC | 4.06e-09 | -4.11e-01 | 0.1551 |
57447 | NDRG2 | GSM4909301 | Human | Breast | IDC | 6.74e-34 | -7.80e-01 | 0.1577 |
57447 | NDRG2 | GSM4909302 | Human | Breast | IDC | 2.60e-25 | -7.38e-01 | 0.1545 |
57447 | NDRG2 | GSM4909304 | Human | Breast | IDC | 6.69e-21 | -7.16e-01 | 0.1636 |
57447 | NDRG2 | GSM4909306 | Human | Breast | IDC | 2.65e-10 | -4.57e-01 | 0.1564 |
57447 | NDRG2 | GSM4909307 | Human | Breast | IDC | 5.08e-11 | -4.64e-01 | 0.1569 |
57447 | NDRG2 | GSM4909308 | Human | Breast | IDC | 5.91e-25 | -7.71e-01 | 0.158 |
57447 | NDRG2 | GSM4909311 | Human | Breast | IDC | 3.51e-25 | -5.05e-01 | 0.1534 |
57447 | NDRG2 | GSM4909312 | Human | Breast | IDC | 1.16e-22 | -6.85e-01 | 0.1552 |
Page: 1 2 3 4 5 6 7 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0021762 | Colorectum | AD | substantia nigra development | 21/3918 | 44/18723 | 6.60e-05 | 1.07e-03 | 21 |
GO:0048857 | Colorectum | AD | neural nucleus development | 27/3918 | 64/18723 | 9.57e-05 | 1.45e-03 | 27 |
GO:0043409 | Colorectum | AD | negative regulation of MAPK cascade | 57/3918 | 180/18723 | 4.61e-04 | 5.14e-03 | 57 |
GO:0030901 | Colorectum | AD | midbrain development | 32/3918 | 90/18723 | 9.45e-04 | 8.95e-03 | 32 |
GO:00217621 | Colorectum | SER | substantia nigra development | 21/2897 | 44/18723 | 4.77e-07 | 2.40e-05 | 21 |
GO:00488571 | Colorectum | SER | neural nucleus development | 26/2897 | 64/18723 | 1.09e-06 | 5.11e-05 | 26 |
GO:00309011 | Colorectum | SER | midbrain development | 29/2897 | 90/18723 | 5.50e-05 | 1.30e-03 | 29 |
GO:00160551 | Colorectum | SER | Wnt signaling pathway | 97/2897 | 444/18723 | 2.02e-04 | 3.68e-03 | 97 |
GO:01987381 | Colorectum | SER | cell-cell signaling by wnt | 97/2897 | 446/18723 | 2.39e-04 | 4.11e-03 | 97 |
GO:00434091 | Colorectum | SER | negative regulation of MAPK cascade | 45/2897 | 180/18723 | 5.81e-04 | 7.98e-03 | 45 |
GO:00160552 | Colorectum | MSS | Wnt signaling pathway | 124/3467 | 444/18723 | 6.06e-07 | 2.26e-05 | 124 |
GO:01987382 | Colorectum | MSS | cell-cell signaling by wnt | 124/3467 | 446/18723 | 7.83e-07 | 2.77e-05 | 124 |
GO:00217622 | Colorectum | MSS | substantia nigra development | 21/3467 | 44/18723 | 9.54e-06 | 2.33e-04 | 21 |
GO:00488572 | Colorectum | MSS | neural nucleus development | 26/3467 | 64/18723 | 3.19e-05 | 6.30e-04 | 26 |
GO:00309012 | Colorectum | MSS | midbrain development | 31/3467 | 90/18723 | 2.36e-04 | 3.24e-03 | 31 |
GO:00434092 | Colorectum | MSS | negative regulation of MAPK cascade | 50/3467 | 180/18723 | 1.45e-03 | 1.35e-02 | 50 |
GO:0048659 | Colorectum | MSS | smooth muscle cell proliferation | 49/3467 | 184/18723 | 4.08e-03 | 2.97e-02 | 49 |
GO:0048660 | Colorectum | MSS | regulation of smooth muscle cell proliferation | 48/3467 | 180/18723 | 4.32e-03 | 3.07e-02 | 48 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
Page: 1 2 3 4 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDRG2 | SNV | Missense_Mutation | novel | c.970N>T | p.Arg324Cys | p.R324C | Q9UN36 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
NDRG2 | SNV | Missense_Mutation | novel | c.34N>A | p.Glu12Lys | p.E12K | Q9UN36 | protein_coding | tolerated(0.89) | benign(0.352) | TCGA-BH-A0HU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
NDRG2 | SNV | Missense_Mutation | c.895C>G | p.Gln299Glu | p.Q299E | Q9UN36 | protein_coding | deleterious(0.02) | benign(0.27) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NDRG2 | SNV | Missense_Mutation | c.528G>T | p.Lys176Asn | p.K176N | Q9UN36 | protein_coding | deleterious(0.01) | probably_damaging(0.917) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NDRG2 | SNV | Missense_Mutation | rs750572401 | c.95G>A | p.Arg32Gln | p.R32Q | Q9UN36 | protein_coding | tolerated(0.57) | benign(0.001) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
NDRG2 | SNV | Missense_Mutation | c.279N>T | p.Gln93His | p.Q93H | Q9UN36 | protein_coding | deleterious(0.04) | benign(0.443) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NDRG2 | insertion | Nonsense_Mutation | novel | c.57_58insTTAGAATAAGATCAGT | p.Thr20LeufsTer3 | p.T20Lfs*3 | Q9UN36 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NDRG2 | SNV | Missense_Mutation | novel | c.805G>T | p.Asp269Tyr | p.D269Y | Q9UN36 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NDRG2 | SNV | Missense_Mutation | novel | c.1076C>A | p.Ser359Tyr | p.S359Y | Q9UN36 | protein_coding | deleterious(0.03) | benign(0.181) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NDRG2 | SNV | Missense_Mutation | rs572120906 | c.1034N>A | p.Arg345His | p.R345H | Q9UN36 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |