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Gene: NAPA |
Gene summary for NAPA |
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Gene information | Species | Human | Gene symbol | NAPA | Gene ID | 8775 |
Gene name | NSF attachment protein alpha | |
Gene Alias | SNAPA | |
Cytomap | 19q13.32-q13.33 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | A0A024R0R9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8775 | NAPA | LZE2D | Human | Esophagus | HGIN | 4.06e-04 | 5.73e-01 | 0.0642 |
8775 | NAPA | LZE2T | Human | Esophagus | ESCC | 1.68e-06 | 9.18e-01 | 0.082 |
8775 | NAPA | LZE4T | Human | Esophagus | ESCC | 4.94e-36 | 9.53e-01 | 0.0811 |
8775 | NAPA | LZE5T | Human | Esophagus | ESCC | 1.44e-18 | 9.53e-01 | 0.0514 |
8775 | NAPA | LZE7T | Human | Esophagus | ESCC | 4.73e-20 | 8.10e-01 | 0.0667 |
8775 | NAPA | LZE8T | Human | Esophagus | ESCC | 2.18e-30 | 8.28e-01 | 0.067 |
8775 | NAPA | LZE20T | Human | Esophagus | ESCC | 2.05e-28 | 8.44e-01 | 0.0662 |
8775 | NAPA | LZE21D1 | Human | Esophagus | HGIN | 2.94e-02 | 5.59e-01 | 0.0632 |
8775 | NAPA | LZE22D1 | Human | Esophagus | HGIN | 5.37e-09 | 4.77e-01 | 0.0595 |
8775 | NAPA | LZE22T | Human | Esophagus | ESCC | 4.72e-15 | 9.88e-01 | 0.068 |
8775 | NAPA | LZE24T | Human | Esophagus | ESCC | 2.44e-52 | 1.37e+00 | 0.0596 |
8775 | NAPA | LZE22D3 | Human | Esophagus | HGIN | 2.46e-05 | 1.04e+00 | 0.0653 |
8775 | NAPA | LZE21T | Human | Esophagus | ESCC | 6.14e-12 | 6.80e-01 | 0.0655 |
8775 | NAPA | LZE6T | Human | Esophagus | ESCC | 1.35e-21 | 6.95e-01 | 0.0845 |
8775 | NAPA | P1T-E | Human | Esophagus | ESCC | 5.78e-38 | 1.62e+00 | 0.0875 |
8775 | NAPA | P2T-E | Human | Esophagus | ESCC | 1.14e-79 | 1.25e+00 | 0.1177 |
8775 | NAPA | P4T-E | Human | Esophagus | ESCC | 2.59e-55 | 1.06e+00 | 0.1323 |
8775 | NAPA | P5T-E | Human | Esophagus | ESCC | 4.09e-44 | 8.25e-01 | 0.1327 |
8775 | NAPA | P8T-E | Human | Esophagus | ESCC | 5.97e-107 | 1.82e+00 | 0.0889 |
8775 | NAPA | P9T-E | Human | Esophagus | ESCC | 8.44e-46 | 9.99e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004325422 | Liver | HCC | regulation of protein-containing complex assembly | 264/7958 | 428/18723 | 5.47e-16 | 4.39e-14 | 264 |
GO:003298411 | Liver | HCC | protein-containing complex disassembly | 138/7958 | 224/18723 | 5.59e-09 | 1.46e-07 | 138 |
GO:0061025 | Liver | HCC | membrane fusion | 88/7958 | 163/18723 | 1.98e-03 | 1.00e-02 | 88 |
GO:00327811 | Liver | HCC | positive regulation of ATPase activity | 19/7958 | 27/18723 | 3.18e-03 | 1.47e-02 | 19 |
GO:004346211 | Liver | HCC | regulation of ATPase activity | 29/7958 | 46/18723 | 3.95e-03 | 1.74e-02 | 29 |
GO:0006891 | Liver | HCC | intra-Golgi vesicle-mediated transport | 22/7958 | 33/18723 | 4.38e-03 | 1.90e-02 | 22 |
GO:00436242 | Liver | HCC | cellular protein complex disassembly | 71/7958 | 136/18723 | 1.39e-02 | 4.95e-02 | 71 |
GO:00990034 | Lung | IAC | vesicle-mediated transport in synapse | 39/2061 | 200/18723 | 2.71e-04 | 4.49e-03 | 39 |
GO:00432548 | Lung | IAC | regulation of protein-containing complex assembly | 68/2061 | 428/18723 | 1.20e-03 | 1.38e-02 | 68 |
GO:00481937 | Lung | IAC | Golgi vesicle transport | 49/2061 | 296/18723 | 2.35e-03 | 2.28e-02 | 49 |
GO:00995043 | Lung | IAC | synaptic vesicle cycle | 33/2061 | 181/18723 | 2.47e-03 | 2.33e-02 | 33 |
GO:00224118 | Lung | IAC | cellular component disassembly | 68/2061 | 443/18723 | 2.89e-03 | 2.60e-02 | 68 |
GO:009900311 | Lung | AIS | vesicle-mediated transport in synapse | 42/1849 | 200/18723 | 1.87e-06 | 1.10e-04 | 42 |
GO:009950411 | Lung | AIS | synaptic vesicle cycle | 36/1849 | 181/18723 | 3.42e-05 | 1.05e-03 | 36 |
GO:004325413 | Lung | AIS | regulation of protein-containing complex assembly | 68/1849 | 428/18723 | 5.51e-05 | 1.56e-03 | 68 |
GO:004819312 | Lung | AIS | Golgi vesicle transport | 46/1849 | 296/18723 | 1.32e-03 | 1.64e-02 | 46 |
GO:004325423 | Lung | MIAC | regulation of protein-containing complex assembly | 44/967 | 428/18723 | 1.11e-05 | 9.00e-04 | 44 |
GO:009900321 | Lung | MIAC | vesicle-mediated transport in synapse | 20/967 | 200/18723 | 3.64e-03 | 4.60e-02 | 20 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:002241119 | Oral cavity | OSCC | cellular component disassembly | 283/7305 | 443/18723 | 9.57e-27 | 3.37e-24 | 283 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NAPA | SNV | Missense_Mutation | novel | c.791N>T | p.Lys264Met | p.K264M | P54920 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NAPA | SNV | Missense_Mutation | c.698N>T | p.Pro233Leu | p.P233L | P54920 | protein_coding | deleterious(0) | possibly_damaging(0.625) | TCGA-B6-A0X5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
NAPA | SNV | Missense_Mutation | c.49N>T | p.Ala17Ser | p.A17S | P54920 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-EW-A1OZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | |
NAPA | SNV | Missense_Mutation | c.547N>C | p.Asp183His | p.D183H | P54920 | protein_coding | deleterious(0.04) | benign(0.013) | TCGA-EW-A1PB-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
NAPA | SNV | Missense_Mutation | rs757031862 | c.799N>A | p.Asp267Asn | p.D267N | P54920 | protein_coding | tolerated(0.05) | probably_damaging(0.923) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NAPA | SNV | Missense_Mutation | c.244G>A | p.Ala82Thr | p.A82T | P54920 | protein_coding | deleterious(0.02) | possibly_damaging(0.902) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NAPA | SNV | Missense_Mutation | c.697N>T | p.Pro233Ser | p.P233S | P54920 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NAPA | SNV | Missense_Mutation | c.127N>A | p.Glu43Lys | p.E43K | P54920 | protein_coding | deleterious(0.01) | benign(0.265) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NAPA | SNV | Missense_Mutation | novel | c.610G>T | p.Asp204Tyr | p.D204Y | P54920 | protein_coding | deleterious(0.03) | possibly_damaging(0.694) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NAPA | SNV | Missense_Mutation | novel | c.505G>A | p.Ala169Thr | p.A169T | P54920 | protein_coding | deleterious(0.01) | probably_damaging(0.959) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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