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Gene: NAP1L4 |
Gene summary for NAP1L4 |
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Gene information | Species | Human | Gene symbol | NAP1L4 | Gene ID | 4676 |
Gene name | nucleosome assembly protein 1 like 4 | |
Gene Alias | NAP1L4b | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0006323 | UniProtAcc | A0A024RCC9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4676 | NAP1L4 | CA_HPV_1 | Human | Cervix | CC | 1.68e-06 | -1.37e-01 | 0.0264 |
4676 | NAP1L4 | CCI_2 | Human | Cervix | CC | 7.63e-03 | 5.60e-01 | 0.5249 |
4676 | NAP1L4 | CCI_3 | Human | Cervix | CC | 7.48e-11 | 8.16e-01 | 0.516 |
4676 | NAP1L4 | LZE2T | Human | Esophagus | ESCC | 6.25e-06 | 4.77e-01 | 0.082 |
4676 | NAP1L4 | LZE3D | Human | Esophagus | HGIN | 1.97e-03 | 8.95e-01 | 0.0668 |
4676 | NAP1L4 | LZE4T | Human | Esophagus | ESCC | 8.67e-21 | 6.55e-01 | 0.0811 |
4676 | NAP1L4 | LZE7T | Human | Esophagus | ESCC | 8.52e-13 | 8.14e-01 | 0.0667 |
4676 | NAP1L4 | LZE8T | Human | Esophagus | ESCC | 1.41e-16 | 7.33e-01 | 0.067 |
4676 | NAP1L4 | LZE20T | Human | Esophagus | ESCC | 3.89e-05 | 2.52e-01 | 0.0662 |
4676 | NAP1L4 | LZE22D1 | Human | Esophagus | HGIN | 8.29e-10 | 2.34e-01 | 0.0595 |
4676 | NAP1L4 | LZE22T | Human | Esophagus | ESCC | 6.40e-08 | 5.82e-01 | 0.068 |
4676 | NAP1L4 | LZE24T | Human | Esophagus | ESCC | 1.49e-21 | 7.35e-01 | 0.0596 |
4676 | NAP1L4 | LZE21T | Human | Esophagus | ESCC | 2.14e-07 | 4.99e-01 | 0.0655 |
4676 | NAP1L4 | LZE6T | Human | Esophagus | ESCC | 2.37e-11 | 5.21e-01 | 0.0845 |
4676 | NAP1L4 | P1T-E | Human | Esophagus | ESCC | 6.79e-21 | 7.46e-01 | 0.0875 |
4676 | NAP1L4 | P2T-E | Human | Esophagus | ESCC | 2.69e-86 | 1.50e+00 | 0.1177 |
4676 | NAP1L4 | P4T-E | Human | Esophagus | ESCC | 8.39e-31 | 8.32e-01 | 0.1323 |
4676 | NAP1L4 | P5T-E | Human | Esophagus | ESCC | 6.05e-20 | 5.66e-01 | 0.1327 |
4676 | NAP1L4 | P8T-E | Human | Esophagus | ESCC | 1.63e-26 | 5.16e-01 | 0.0889 |
4676 | NAP1L4 | P9T-E | Human | Esophagus | ESCC | 8.08e-29 | 7.40e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:00063385 | Thyroid | PTC | chromatin remodeling | 106/5968 | 255/18723 | 6.56e-04 | 4.13e-03 | 106 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
GO:000633813 | Thyroid | ATC | chromatin remodeling | 109/6293 | 255/18723 | 1.38e-03 | 7.15e-03 | 109 |
GO:00718242 | Thyroid | ATC | protein-DNA complex subunit organization | 103/6293 | 241/18723 | 1.84e-03 | 9.03e-03 | 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NAP1L4 | SNV | Missense_Mutation | c.541G>C | p.Asp181His | p.D181H | Q99733 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NAP1L4 | SNV | Missense_Mutation | novel | c.184N>T | p.Ala62Ser | p.A62S | Q99733 | protein_coding | tolerated(0.49) | benign(0.028) | TCGA-C8-A8HR-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
NAP1L4 | SNV | Missense_Mutation | novel | c.146N>A | p.Pro49His | p.P49H | Q99733 | protein_coding | deleterious(0.04) | benign(0.308) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NAP1L4 | SNV | Missense_Mutation | novel | c.235C>T | p.His79Tyr | p.H79Y | Q99733 | protein_coding | deleterious(0.04) | possibly_damaging(0.745) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
NAP1L4 | SNV | Missense_Mutation | rs201761556 | c.842N>T | p.Thr281Met | p.T281M | Q99733 | protein_coding | deleterious(0.01) | possibly_damaging(0.783) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NAP1L4 | SNV | Missense_Mutation | novel | c.85G>T | p.Asp29Tyr | p.D29Y | Q99733 | protein_coding | deleterious(0.03) | possibly_damaging(0.629) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NAP1L4 | SNV | Missense_Mutation | novel | c.476T>G | p.Ile159Ser | p.I159S | Q99733 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NAP1L4 | SNV | Missense_Mutation | c.451G>A | p.Ala151Thr | p.A151T | Q99733 | protein_coding | tolerated(0.47) | benign(0.026) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NAP1L4 | SNV | Missense_Mutation | novel | c.415A>T | p.Ser139Cys | p.S139C | Q99733 | protein_coding | deleterious(0.02) | possibly_damaging(0.84) | TCGA-AG-A023-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
NAP1L4 | SNV | Missense_Mutation | rs754415348 | c.449N>T | p.Thr150Met | p.T150M | Q99733 | protein_coding | tolerated(0.11) | possibly_damaging(0.738) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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