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Gene: NAA50 |
Gene summary for NAA50 |
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Gene information | Species | Human | Gene symbol | NAA50 | Gene ID | 80218 |
Gene name | N-alpha-acetyltransferase 50, NatE catalytic subunit | |
Gene Alias | MAK3 | |
Cytomap | 3q13.31 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | E7EQ69 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80218 | NAA50 | CA_HPV_3 | Human | Cervix | CC | 6.83e-03 | 1.21e-01 | 0.0414 |
80218 | NAA50 | CCI_2 | Human | Cervix | CC | 2.47e-09 | 8.33e-01 | 0.5249 |
80218 | NAA50 | CCI_3 | Human | Cervix | CC | 1.89e-08 | 9.96e-01 | 0.516 |
80218 | NAA50 | Tumor | Human | Cervix | CC | 1.25e-18 | 4.72e-01 | 0.1241 |
80218 | NAA50 | sample1 | Human | Cervix | CC | 2.20e-06 | 4.65e-01 | 0.0959 |
80218 | NAA50 | sample3 | Human | Cervix | CC | 9.71e-26 | 4.57e-01 | 0.1387 |
80218 | NAA50 | T1 | Human | Cervix | CC | 5.88e-07 | 3.77e-01 | 0.0918 |
80218 | NAA50 | T3 | Human | Cervix | CC | 3.20e-23 | 4.48e-01 | 0.1389 |
80218 | NAA50 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.71e-10 | -4.71e-01 | 0.0155 |
80218 | NAA50 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.77e-02 | -4.55e-01 | -0.1207 |
80218 | NAA50 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.15e-12 | -3.91e-01 | -0.1464 |
80218 | NAA50 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.89e-05 | -3.37e-01 | -0.1001 |
80218 | NAA50 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.92e-03 | -3.39e-01 | 0.096 |
80218 | NAA50 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.57e-03 | -4.34e-01 | 0.0338 |
80218 | NAA50 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.84e-05 | -3.69e-01 | 0.0674 |
80218 | NAA50 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.92e-03 | -2.83e-01 | 0.3859 |
80218 | NAA50 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.26e-15 | -4.80e-01 | 0.3005 |
80218 | NAA50 | F007 | Human | Colorectum | FAP | 2.47e-02 | -3.39e-01 | 0.1176 |
80218 | NAA50 | A001-C-207 | Human | Colorectum | FAP | 1.03e-03 | -3.05e-01 | 0.1278 |
80218 | NAA50 | A015-C-203 | Human | Colorectum | FAP | 6.96e-24 | -4.32e-01 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070623 | Colorectum | CRC | sister chromatid cohesion | 16/2078 | 62/18723 | 9.40e-04 | 1.15e-02 | 16 |
GO:00070643 | Colorectum | CRC | mitotic sister chromatid cohesion | 9/2078 | 28/18723 | 2.43e-03 | 2.30e-02 | 9 |
GO:00516044 | Colorectum | CRC | protein maturation | 47/2078 | 294/18723 | 6.52e-03 | 4.70e-02 | 47 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
GO:001839313 | Esophagus | ESCC | internal peptidyl-lysine acetylation | 114/8552 | 158/18723 | 1.16e-11 | 4.24e-10 | 114 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:000647513 | Esophagus | ESCC | internal protein amino acid acetylation | 115/8552 | 160/18723 | 1.43e-11 | 5.08e-10 | 115 |
GO:00165735 | Esophagus | ESCC | histone acetylation | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:004396712 | Esophagus | ESCC | histone H4 acetylation | 53/8552 | 67/18723 | 2.11e-08 | 4.03e-07 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NAA50 | SNV | Missense_Mutation | rs777291080 | c.433G>A | p.Ala145Thr | p.A145T | Q9GZZ1 | protein_coding | tolerated(0.14) | benign(0.049) | TCGA-AR-A1AY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Doxorubicin | SD |
NAA50 | SNV | Missense_Mutation | c.388N>C | p.Glu130Gln | p.E130Q | Q9GZZ1 | protein_coding | tolerated(0.07) | benign(0.01) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NAA50 | SNV | Missense_Mutation | novel | c.131N>G | p.Glu44Gly | p.E44G | Q9GZZ1 | protein_coding | deleterious(0) | benign(0.151) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
NAA50 | SNV | Missense_Mutation | c.74N>C | p.Val25Ala | p.V25A | Q9GZZ1 | protein_coding | tolerated(0.3) | benign(0.018) | TCGA-AA-3673-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NAA50 | SNV | Missense_Mutation | novel | c.405N>T | p.Lys135Asn | p.K135N | Q9GZZ1 | protein_coding | tolerated(0.21) | possibly_damaging(0.503) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NAA50 | SNV | Missense_Mutation | novel | c.301N>C | p.Glu101Gln | p.E101Q | Q9GZZ1 | protein_coding | tolerated(0.19) | benign(0.277) | TCGA-AX-A2H2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NAA50 | SNV | Missense_Mutation | novel | c.153N>A | p.Phe51Leu | p.F51L | Q9GZZ1 | protein_coding | tolerated(0.1) | benign(0.067) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
NAA50 | SNV | Missense_Mutation | novel | c.334C>T | p.His112Tyr | p.H112Y | Q9GZZ1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NAA50 | SNV | Missense_Mutation | rs763096981 | c.251G>A | p.Arg84Gln | p.R84Q | Q9GZZ1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-94-7943-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NAA50 | SNV | Missense_Mutation | novel | c.236N>A | p.Cys79Tyr | p.C79Y | Q9GZZ1 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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