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Gene: MYRIP |
Gene summary for MYRIP |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MYRIP | Gene ID | 25924 |
| Gene name | myosin VIIA and Rab interacting protein | |
| Gene Alias | SLAC2-C | |
| Cytomap | 3p22.1 | |
| Gene Type | protein-coding | GO ID | GO:0002790 | UniProtAcc | Q8NFW9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 25924 | MYRIP | HTA11_696_2000001011 | Human | Colorectum | AD | 2.57e-05 | 4.11e-01 | -0.1464 |
| 25924 | MYRIP | HTA11_866_2000001011 | Human | Colorectum | AD | 2.95e-10 | 5.35e-01 | -0.1001 |
| 25924 | MYRIP | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.15e-08 | 5.95e-01 | -0.059 |
| 25924 | MYRIP | HTA11_866_3004761011 | Human | Colorectum | AD | 1.61e-05 | 3.36e-01 | 0.096 |
| 25924 | MYRIP | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.50e-12 | 6.81e-01 | 0.0338 |
| 25924 | MYRIP | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.30e-04 | 2.68e-01 | 0.0674 |
| 25924 | MYRIP | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.91e-04 | 4.48e-01 | 0.0588 |
| 25924 | MYRIP | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.64e-09 | 3.91e-01 | 0.294 |
| 25924 | MYRIP | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.79e-09 | 8.15e-01 | 0.281 |
| 25924 | MYRIP | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.46e-22 | 7.17e-01 | 0.3859 |
| 25924 | MYRIP | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.79e-08 | 2.94e-01 | 0.3005 |
| 25924 | MYRIP | F007 | Human | Colorectum | FAP | 4.53e-20 | 1.07e+00 | 0.1176 |
| 25924 | MYRIP | A002-C-010 | Human | Colorectum | FAP | 1.74e-21 | 7.14e-01 | 0.242 |
| 25924 | MYRIP | A001-C-207 | Human | Colorectum | FAP | 1.52e-09 | 7.13e-01 | 0.1278 |
| 25924 | MYRIP | A015-C-203 | Human | Colorectum | FAP | 2.29e-12 | 6.08e-01 | -0.1294 |
| 25924 | MYRIP | A014-C-040 | Human | Colorectum | FAP | 1.36e-03 | 7.53e-01 | -0.1184 |
| 25924 | MYRIP | A002-C-201 | Human | Colorectum | FAP | 7.34e-09 | 6.32e-01 | 0.0324 |
| 25924 | MYRIP | A002-C-203 | Human | Colorectum | FAP | 3.40e-06 | 4.75e-01 | 0.2786 |
| 25924 | MYRIP | A001-C-108 | Human | Colorectum | FAP | 1.11e-11 | 6.48e-01 | -0.0272 |
| 25924 | MYRIP | A002-C-021 | Human | Colorectum | FAP | 6.64e-31 | 8.76e-01 | 0.1171 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00512222 | Colorectum | MSS | positive regulation of protein transport | 104/3467 | 303/18723 | 3.23e-11 | 4.11e-09 | 104 |
| GO:00507082 | Colorectum | MSS | regulation of protein secretion | 78/3467 | 268/18723 | 1.47e-05 | 3.33e-04 | 78 |
| GO:00093062 | Colorectum | MSS | protein secretion | 98/3467 | 359/18723 | 2.43e-05 | 5.09e-04 | 98 |
| GO:00355922 | Colorectum | MSS | establishment of protein localization to extracellular region | 98/3467 | 360/18723 | 2.75e-05 | 5.58e-04 | 98 |
| GO:00716922 | Colorectum | MSS | protein localization to extracellular region | 99/3467 | 368/18723 | 4.17e-05 | 7.83e-04 | 99 |
| GO:00507962 | Colorectum | MSS | regulation of insulin secretion | 50/3467 | 165/18723 | 1.61e-04 | 2.31e-03 | 50 |
| GO:00300732 | Colorectum | MSS | insulin secretion | 56/3467 | 195/18723 | 3.21e-04 | 4.18e-03 | 56 |
| GO:00507141 | Colorectum | MSS | positive regulation of protein secretion | 42/3467 | 137/18723 | 3.95e-04 | 4.91e-03 | 42 |
| GO:00158332 | Colorectum | MSS | peptide transport | 71/3467 | 264/18723 | 4.79e-04 | 5.60e-03 | 71 |
| GO:00320241 | Colorectum | MSS | positive regulation of insulin secretion | 27/3467 | 78/18723 | 5.31e-04 | 5.99e-03 | 27 |
| GO:19035321 | Colorectum | MSS | positive regulation of secretion by cell | 74/3467 | 282/18723 | 7.93e-04 | 8.36e-03 | 74 |
| GO:00510472 | Colorectum | MSS | positive regulation of secretion | 80/3467 | 310/18723 | 8.55e-04 | 8.75e-03 | 80 |
| GO:00900872 | Colorectum | MSS | regulation of peptide transport | 55/3467 | 202/18723 | 1.44e-03 | 1.34e-02 | 55 |
| GO:00027912 | Colorectum | MSS | regulation of peptide secretion | 54/3467 | 200/18723 | 1.94e-03 | 1.67e-02 | 54 |
| GO:00300721 | Colorectum | MSS | peptide hormone secretion | 62/3467 | 236/18723 | 1.95e-03 | 1.68e-02 | 62 |
| GO:00902762 | Colorectum | MSS | regulation of peptide hormone secretion | 53/3467 | 196/18723 | 2.04e-03 | 1.75e-02 | 53 |
| GO:00428861 | Colorectum | MSS | amide transport | 76/3467 | 301/18723 | 2.14e-03 | 1.80e-02 | 76 |
| GO:00027901 | Colorectum | MSS | peptide secretion | 63/3467 | 242/18723 | 2.28e-03 | 1.87e-02 | 63 |
| GO:19049514 | Colorectum | FAP | positive regulation of establishment of protein localization | 82/2622 | 319/18723 | 1.83e-08 | 1.87e-06 | 82 |
| GO:00512224 | Colorectum | FAP | positive regulation of protein transport | 78/2622 | 303/18723 | 3.79e-08 | 3.23e-06 | 78 |
| Page: 1 2 3 4 5 6 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MYRIP | SNV | Missense_Mutation | c.1949N>C | p.Leu650Pro | p.L650P | Q8NFW9 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| MYRIP | SNV | Missense_Mutation | c.1665N>C | p.Gln555His | p.Q555H | Q8NFW9 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AN-A0AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| MYRIP | SNV | Missense_Mutation | c.2361N>T | p.Arg787Ser | p.R787S | Q8NFW9 | protein_coding | tolerated(0.36) | benign(0.396) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| MYRIP | SNV | Missense_Mutation | c.2263A>G | p.Ile755Val | p.I755V | Q8NFW9 | protein_coding | tolerated(0.34) | possibly_damaging(0.536) | TCGA-BH-A0BG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| MYRIP | SNV | Missense_Mutation | c.348N>T | p.Gln116His | p.Q116H | Q8NFW9 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-BH-A18L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| MYRIP | SNV | Missense_Mutation | c.388N>C | p.Lys130Gln | p.K130Q | Q8NFW9 | protein_coding | deleterious(0.02) | probably_damaging(0.958) | TCGA-D8-A1X9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
| MYRIP | SNV | Missense_Mutation | novel | c.540G>T | p.Arg180Ser | p.R180S | Q8NFW9 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-LL-A5YP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
| MYRIP | insertion | Frame_Shift_Ins | novel | c.1541_1542insACTTCTCTCTCTTTCTCTATGGATTGCAAATGCACACAGAAAAT | p.Glu515LeufsTer52 | p.E515Lfs*52 | Q8NFW9 | protein_coding | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| MYRIP | insertion | Nonsense_Mutation | novel | c.1181_1182insATAAAGAGAAGCCTGAGATCCAGGCCCTGCCTCAGGGAC | p.Gly394_Ser395insTer | p.G394_S395ins* | Q8NFW9 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| MYRIP | SNV | Missense_Mutation | novel | c.809C>T | p.Thr270Ile | p.T270I | Q8NFW9 | protein_coding | tolerated(0.21) | benign(0.014) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| Page: 1 2 3 4 5 6 7 8 9 10 11 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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