![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MUC6 |
Gene summary for MUC6 |
![]() |
Gene information | Species | Human | Gene symbol | MUC6 | Gene ID | 4588 |
Gene name | mucin 6, oligomeric mucus/gel-forming | |
Gene Alias | MUC-6 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | Q6W4X9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4588 | MUC6 | Pat01-B | Human | Stomach | GC | 3.44e-04 | -4.48e-01 | 0.5754 |
4588 | MUC6 | Pat02-B | Human | Stomach | GC | 5.94e-25 | 5.94e-01 | 0.0368 |
4588 | MUC6 | Pat04-B | Human | Stomach | GC | 4.74e-04 | -2.17e-01 | -0.1483 |
4588 | MUC6 | Pat05-B | Human | Stomach | GC | 9.30e-06 | -5.78e-02 | -0.0353 |
4588 | MUC6 | Pat06-B | Human | Stomach | GC | 1.07e-08 | 4.91e-02 | -0.1961 |
4588 | MUC6 | Pat15-B | Human | Stomach | GC | 1.26e-09 | 6.87e-01 | -0.0778 |
4588 | MUC6 | Pat16-B | Human | Stomach | GC | 2.44e-02 | -2.63e-01 | 0.1918 |
4588 | MUC6 | Pat17-B | Human | Stomach | GC | 2.16e-06 | -4.83e-01 | 0.3109 |
4588 | MUC6 | Pat18-B | Human | Stomach | GC | 1.27e-10 | 5.35e-01 | -0.0432 |
4588 | MUC6 | Pat19-B | Human | Stomach | GC | 6.86e-08 | 1.47e-01 | 0.0826 |
4588 | MUC6 | Pat22-B | Human | Stomach | GC | 1.05e-08 | -8.74e-02 | -0.1042 |
4588 | MUC6 | Pat24-B | Human | Stomach | GC | 4.82e-05 | -5.43e-02 | -0.1184 |
4588 | MUC6 | Pat25-A | Human | Stomach | CAG with IM | 1.44e-08 | 2.82e-01 | -0.1648 |
4588 | MUC6 | Pat26-A | Human | Stomach | CSG | 1.49e-25 | -7.75e-02 | -0.2402 |
4588 | MUC6 | CAG_2 | Human | Stomach | CAG | 2.14e-05 | 5.17e-01 | -0.2831 |
4588 | MUC6 | CAG_3 | Human | Stomach | CAG | 4.75e-11 | 6.43e-01 | -0.2766 |
4588 | MUC6 | SIM_2 | Human | Stomach | SIM | 1.55e-04 | -1.29e-02 | 0.3139 |
4588 | MUC6 | SIM_4 | Human | Stomach | SIM | 1.62e-06 | -5.27e-01 | 0.2664 |
4588 | MUC6 | EGC | Human | Stomach | GC | 7.07e-06 | -4.93e-01 | 0.1683 |
4588 | MUC6 | Pt1_Superficial | Human | Stomach | GC | 2.73e-05 | -5.60e-01 | 0.1036 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006024931 | Stomach | CAG | anatomical structure homeostasis | 27/552 | 314/18723 | 7.25e-07 | 4.98e-05 | 27 |
GO:00302773 | Stomach | CAG | maintenance of gastrointestinal epithelium | 6/552 | 22/18723 | 3.19e-05 | 1.09e-03 | 6 |
GO:002260031 | Stomach | CAG | digestive system process | 12/552 | 104/18723 | 5.62e-05 | 1.63e-03 | 12 |
GO:00106693 | Stomach | CAG | epithelial structure maintenance | 6/552 | 30/18723 | 2.08e-04 | 4.32e-03 | 6 |
GO:00075865 | Stomach | SIM | digestion | 24/708 | 137/18723 | 3.20e-10 | 6.29e-08 | 24 |
GO:00226005 | Stomach | SIM | digestive system process | 18/708 | 104/18723 | 6.37e-08 | 6.30e-06 | 18 |
GO:00302775 | Stomach | SIM | maintenance of gastrointestinal epithelium | 7/708 | 22/18723 | 1.11e-05 | 4.04e-04 | 7 |
GO:006024951 | Stomach | SIM | anatomical structure homeostasis | 28/708 | 314/18723 | 2.52e-05 | 7.73e-04 | 28 |
GO:000189451 | Stomach | SIM | tissue homeostasis | 25/708 | 268/18723 | 3.22e-05 | 9.44e-04 | 25 |
GO:00106695 | Stomach | SIM | epithelial structure maintenance | 7/708 | 30/18723 | 1.02e-04 | 2.48e-03 | 7 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUC6 | SNV | Missense_Mutation | novel | c.436N>G | p.Leu146Val | p.L146V | Q6W4X9 | protein_coding | deleterious(0.05) | possibly_damaging(0.86) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
MUC6 | SNV | Missense_Mutation | rs200980330 | c.1000N>G | p.Cys334Gly | p.C334G | Q6W4X9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A3W7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
MUC6 | SNV | Missense_Mutation | novel | c.6445C>T | p.His2149Tyr | p.H2149Y | Q6W4X9 | protein_coding | deleterious_low_confidence(0.05) | benign(0.052) | TCGA-AC-A6IX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MUC6 | SNV | Missense_Mutation | c.6440N>A | p.Ser2147Tyr | p.S2147Y | Q6W4X9 | protein_coding | deleterious_low_confidence(0) | benign(0.078) | TCGA-BH-A0BP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MUC6 | SNV | Missense_Mutation | c.6395N>T | p.Ser2132Phe | p.S2132F | Q6W4X9 | protein_coding | deleterious_low_confidence(0.04) | benign(0.003) | TCGA-E2-A1LB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
MUC6 | SNV | Missense_Mutation | novel | c.3422N>T | p.Gly1141Val | p.G1141V | Q6W4X9 | protein_coding | deleterious(0.03) | benign(0.031) | TCGA-HN-A2NL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
MUC6 | SNV | Missense_Mutation | novel | c.641N>A | p.Thr214Asn | p.T214N | Q6W4X9 | protein_coding | deleterious(0.05) | benign(0.007) | TCGA-V7-A7HQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | letrozole | CR |
MUC6 | deletion | Frame_Shift_Del | c.3937_3938delNN | p.Ala1313GlnfsTer83 | p.A1313Qfs*83 | Q6W4X9 | protein_coding | TCGA-BH-A0RX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |||
MUC6 | deletion | Frame_Shift_Del | novel | c.6284delN | p.Pro2095LeufsTer20 | p.P2095Lfs*20 | Q6W4X9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
MUC6 | deletion | Frame_Shift_Del | novel | c.4499delC | p.Pro1500HisfsTer3 | p.P1500Hfs*3 | Q6W4X9 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |