|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: MRTFA |
Gene summary for MRTFA |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MRTFA | Gene ID | 57591 |
| Gene name | myocardin related transcription factor A | |
| Gene Alias | BSAC | |
| Cytomap | 22q13.1-q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0002009 | UniProtAcc | A4FUJ8 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57591 | MRTFA | CCI_1 | Human | Cervix | CC | 1.40e-12 | 9.93e-01 | 0.528 |
| 57591 | MRTFA | CCI_2 | Human | Cervix | CC | 1.35e-15 | 1.31e+00 | 0.5249 |
| 57591 | MRTFA | CCI_3 | Human | Cervix | CC | 8.28e-23 | 1.12e+00 | 0.516 |
| 57591 | MRTFA | Tumor | Human | Cervix | CC | 3.83e-04 | -1.35e-01 | 0.1241 |
| 57591 | MRTFA | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.84e-19 | 3.38e-01 | 0.0155 |
| 57591 | MRTFA | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.28e-25 | 6.28e-01 | -0.1808 |
| 57591 | MRTFA | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.51e-11 | 4.90e-01 | 0.0216 |
| 57591 | MRTFA | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.76e-31 | 8.17e-01 | -0.0811 |
| 57591 | MRTFA | HTA11_78_2000001011 | Human | Colorectum | AD | 6.88e-27 | 6.51e-01 | -0.1088 |
| 57591 | MRTFA | HTA11_347_2000001011 | Human | Colorectum | AD | 2.57e-61 | 1.06e+00 | -0.1954 |
| 57591 | MRTFA | HTA11_411_2000001011 | Human | Colorectum | SER | 6.42e-18 | 1.00e+00 | -0.2602 |
| 57591 | MRTFA | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.13e-25 | 1.11e+00 | -0.2196 |
| 57591 | MRTFA | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.38e-26 | 6.56e-01 | -0.1207 |
| 57591 | MRTFA | HTA11_83_2000001011 | Human | Colorectum | SER | 7.66e-30 | 7.71e-01 | -0.1526 |
| 57591 | MRTFA | HTA11_696_2000001011 | Human | Colorectum | AD | 7.93e-51 | 8.42e-01 | -0.1464 |
| 57591 | MRTFA | HTA11_866_2000001011 | Human | Colorectum | AD | 1.11e-46 | 8.33e-01 | -0.1001 |
| 57591 | MRTFA | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.80e-49 | 1.14e+00 | -0.059 |
| 57591 | MRTFA | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.54e-11 | 5.85e-01 | -0.1706 |
| 57591 | MRTFA | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.32e-13 | 4.96e-01 | -0.2061 |
| 57591 | MRTFA | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.17e-09 | 5.15e-01 | -0.1462 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00426925 | Endometrium | AEH | muscle cell differentiation | 68/2100 | 384/18723 | 8.88e-05 | 1.30e-03 | 68 |
| GO:00443194 | Endometrium | AEH | wound healing, spreading of cells | 11/2100 | 34/18723 | 8.45e-04 | 7.82e-03 | 11 |
| GO:00905054 | Endometrium | AEH | epiboly involved in wound healing | 11/2100 | 34/18723 | 8.45e-04 | 7.82e-03 | 11 |
| GO:00905044 | Endometrium | AEH | epiboly | 11/2100 | 35/18723 | 1.11e-03 | 9.71e-03 | 11 |
| GO:00020112 | Endometrium | AEH | morphogenesis of an epithelial sheet | 14/2100 | 57/18723 | 3.48e-03 | 2.39e-02 | 14 |
| GO:004206017 | Endometrium | EEC | wound healing | 92/2168 | 422/18723 | 1.12e-09 | 9.58e-08 | 92 |
| GO:006161415 | Endometrium | EEC | pri-miRNA transcription by RNA polymerase II | 21/2168 | 55/18723 | 3.30e-07 | 1.33e-05 | 21 |
| GO:190289315 | Endometrium | EEC | regulation of pri-miRNA transcription by RNA polymerase II | 20/2168 | 54/18723 | 1.11e-06 | 3.69e-05 | 20 |
| GO:190289514 | Endometrium | EEC | positive regulation of pri-miRNA transcription by RNA polymerase II | 17/2168 | 42/18723 | 1.67e-06 | 5.12e-05 | 17 |
| GO:004269212 | Endometrium | EEC | muscle cell differentiation | 67/2168 | 384/18723 | 3.87e-04 | 4.12e-03 | 67 |
| GO:004431911 | Endometrium | EEC | wound healing, spreading of cells | 11/2168 | 34/18723 | 1.10e-03 | 9.48e-03 | 11 |
| GO:009050511 | Endometrium | EEC | epiboly involved in wound healing | 11/2168 | 34/18723 | 1.10e-03 | 9.48e-03 | 11 |
| GO:009050411 | Endometrium | EEC | epiboly | 11/2168 | 35/18723 | 1.44e-03 | 1.17e-02 | 11 |
| GO:000201111 | Endometrium | EEC | morphogenesis of an epithelial sheet | 14/2168 | 57/18723 | 4.65e-03 | 2.97e-02 | 14 |
| GO:00616147 | Lung | IAC | pri-miRNA transcription by RNA polymerase II | 19/2061 | 55/18723 | 3.20e-06 | 1.38e-04 | 19 |
| GO:00420608 | Lung | IAC | wound healing | 76/2061 | 422/18723 | 1.01e-05 | 3.23e-04 | 76 |
| GO:19028937 | Lung | IAC | regulation of pri-miRNA transcription by RNA polymerase II | 18/2061 | 54/18723 | 1.02e-05 | 3.23e-04 | 18 |
| GO:19028954 | Lung | IAC | positive regulation of pri-miRNA transcription by RNA polymerase II | 15/2061 | 42/18723 | 2.18e-05 | 6.09e-04 | 15 |
| GO:0042692 | Lung | IAC | muscle cell differentiation | 65/2061 | 384/18723 | 2.75e-04 | 4.54e-03 | 65 |
| GO:0044319 | Lung | IAC | wound healing, spreading of cells | 10/2061 | 34/18723 | 2.79e-03 | 2.52e-02 | 10 |
| Page: 1 2 3 4 5 6 7 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |