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Gene: MPPE1 |
Gene summary for MPPE1 |
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Gene information | Species | Human | Gene symbol | MPPE1 | Gene ID | 65258 |
Gene name | metallophosphoesterase 1 | |
Gene Alias | Cdc1 | |
Cytomap | 18p11.21 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q53F39 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65258 | MPPE1 | LZE4T | Human | Esophagus | ESCC | 6.88e-09 | 2.45e-01 | 0.0811 |
65258 | MPPE1 | LZE7T | Human | Esophagus | ESCC | 2.42e-07 | 3.29e-01 | 0.0667 |
65258 | MPPE1 | LZE8T | Human | Esophagus | ESCC | 2.03e-04 | 2.22e-01 | 0.067 |
65258 | MPPE1 | LZE20T | Human | Esophagus | ESCC | 5.73e-04 | 1.32e-01 | 0.0662 |
65258 | MPPE1 | LZE22T | Human | Esophagus | ESCC | 6.14e-04 | 1.98e-01 | 0.068 |
65258 | MPPE1 | LZE24T | Human | Esophagus | ESCC | 2.35e-16 | 3.61e-01 | 0.0596 |
65258 | MPPE1 | LZE21T | Human | Esophagus | ESCC | 1.02e-03 | 2.90e-01 | 0.0655 |
65258 | MPPE1 | LZE6T | Human | Esophagus | ESCC | 1.01e-03 | 1.50e-01 | 0.0845 |
65258 | MPPE1 | P1T-E | Human | Esophagus | ESCC | 1.77e-07 | 3.28e-01 | 0.0875 |
65258 | MPPE1 | P2T-E | Human | Esophagus | ESCC | 8.41e-26 | 4.32e-01 | 0.1177 |
65258 | MPPE1 | P4T-E | Human | Esophagus | ESCC | 1.05e-24 | 4.38e-01 | 0.1323 |
65258 | MPPE1 | P5T-E | Human | Esophagus | ESCC | 2.89e-24 | 4.41e-01 | 0.1327 |
65258 | MPPE1 | P8T-E | Human | Esophagus | ESCC | 1.35e-22 | 4.40e-01 | 0.0889 |
65258 | MPPE1 | P9T-E | Human | Esophagus | ESCC | 7.49e-25 | 4.30e-01 | 0.1131 |
65258 | MPPE1 | P10T-E | Human | Esophagus | ESCC | 2.53e-22 | 3.21e-01 | 0.116 |
65258 | MPPE1 | P11T-E | Human | Esophagus | ESCC | 9.52e-15 | 5.20e-01 | 0.1426 |
65258 | MPPE1 | P12T-E | Human | Esophagus | ESCC | 1.15e-15 | 2.49e-01 | 0.1122 |
65258 | MPPE1 | P15T-E | Human | Esophagus | ESCC | 1.51e-18 | 3.85e-01 | 0.1149 |
65258 | MPPE1 | P16T-E | Human | Esophagus | ESCC | 3.25e-21 | 2.95e-01 | 0.1153 |
65258 | MPPE1 | P17T-E | Human | Esophagus | ESCC | 5.47e-05 | 2.61e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000688821 | Liver | HCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 100/7958 | 130/18723 | 1.15e-15 | 8.67e-14 | 100 |
GO:00086542 | Liver | HCC | phospholipid biosynthetic process | 150/7958 | 253/18723 | 4.77e-08 | 1.03e-06 | 150 |
GO:00066444 | Liver | HCC | phospholipid metabolic process | 214/7958 | 383/18723 | 7.25e-08 | 1.48e-06 | 214 |
GO:004648611 | Liver | HCC | glycerolipid metabolic process | 215/7958 | 392/18723 | 4.54e-07 | 7.49e-06 | 215 |
GO:00421571 | Liver | HCC | lipoprotein metabolic process | 86/7958 | 135/18723 | 5.21e-07 | 8.38e-06 | 86 |
GO:004501711 | Liver | HCC | glycerolipid biosynthetic process | 143/7958 | 252/18723 | 3.27e-06 | 4.31e-05 | 143 |
GO:00066504 | Liver | HCC | glycerophospholipid metabolic process | 168/7958 | 306/18723 | 7.27e-06 | 8.62e-05 | 168 |
GO:004647411 | Liver | HCC | glycerophospholipid biosynthetic process | 121/7958 | 211/18723 | 9.12e-06 | 1.06e-04 | 121 |
GO:00066431 | Liver | HCC | membrane lipid metabolic process | 115/7958 | 203/18723 | 3.17e-05 | 3.22e-04 | 115 |
GO:00421581 | Liver | HCC | lipoprotein biosynthetic process | 58/7958 | 96/18723 | 2.99e-04 | 2.13e-03 | 58 |
GO:00064971 | Liver | HCC | protein lipidation | 55/7958 | 92/18723 | 6.12e-04 | 3.82e-03 | 55 |
GO:0046467 | Liver | HCC | membrane lipid biosynthetic process | 78/7958 | 142/18723 | 1.85e-03 | 9.46e-03 | 78 |
GO:0006664 | Liver | HCC | glycolipid metabolic process | 57/7958 | 100/18723 | 2.40e-03 | 1.17e-02 | 57 |
GO:0006506 | Liver | HCC | GPI anchor biosynthetic process | 22/7958 | 32/18723 | 2.43e-03 | 1.18e-02 | 22 |
GO:1903509 | Liver | HCC | liposaccharide metabolic process | 57/7958 | 101/18723 | 3.25e-03 | 1.49e-02 | 57 |
GO:0006505 | Liver | HCC | GPI anchor metabolic process | 22/7958 | 33/18723 | 4.38e-03 | 1.90e-02 | 22 |
GO:0006661 | Liver | HCC | phosphatidylinositol biosynthetic process | 69/7958 | 131/18723 | 1.19e-02 | 4.35e-02 | 69 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:00068888 | Oral cavity | OSCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 97/7305 | 130/18723 | 1.42e-16 | 1.15e-14 | 97 |
GO:00066432 | Oral cavity | OSCC | membrane lipid metabolic process | 111/7305 | 203/18723 | 4.02e-06 | 4.69e-05 | 111 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa005632 | Esophagus | ESCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 21/4205 | 26/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 21 |
hsa0056311 | Esophagus | ESCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 21/4205 | 26/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 21 |
hsa00563 | Liver | HCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 18/4020 | 26/8465 | 2.08e-02 | 4.81e-02 | 2.68e-02 | 18 |
hsa005631 | Liver | HCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 18/4020 | 26/8465 | 2.08e-02 | 4.81e-02 | 2.68e-02 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MPPE1 | insertion | In_Frame_Ins | novel | c.932_933insGACTTATTCCCTCCTATTAGAACATATCCC | p.His311delinsGlnThrTyrSerLeuLeuLeuGluHisIlePro | p.H311delinsQTYSLLLEHIP | Q53F39 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
MPPE1 | insertion | Nonsense_Mutation | novel | c.1140_1141insACCACGCCTGGCTAATTTTTGTATTT | p.Ser381ThrfsTer5 | p.S381Tfs*5 | Q53F39 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MPPE1 | SNV | Missense_Mutation | c.475N>C | p.Asp159His | p.D159H | Q53F39 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
MPPE1 | SNV | Missense_Mutation | novel | c.1085G>A | p.Cys362Tyr | p.C362Y | Q53F39 | protein_coding | deleterious(0.02) | benign(0.405) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MPPE1 | SNV | Missense_Mutation | novel | c.1030N>C | p.Tyr344His | p.Y344H | Q53F39 | protein_coding | tolerated(0.12) | benign(0.285) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
MPPE1 | SNV | Missense_Mutation | rs749515863 | c.1058N>A | p.Arg353His | p.R353H | Q53F39 | protein_coding | tolerated(0.54) | benign(0.009) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MPPE1 | SNV | Missense_Mutation | rs536672004 | c.917G>A | p.Ser306Asn | p.S306N | Q53F39 | protein_coding | tolerated(0.49) | benign(0.102) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MPPE1 | SNV | Missense_Mutation | rs758771933 | c.1088N>A | p.Gly363Glu | p.G363E | Q53F39 | protein_coding | tolerated(0.11) | benign(0.081) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MPPE1 | SNV | Missense_Mutation | rs369348336 | c.197N>A | p.Arg66His | p.R66H | Q53F39 | protein_coding | tolerated(0.2) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MPPE1 | SNV | Missense_Mutation | novel | c.761N>A | p.Arg254Gln | p.R254Q | Q53F39 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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