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Gene: MPC1 |
Gene summary for MPC1 |
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Gene information | Species | Human | Gene symbol | MPC1 | Gene ID | 51660 |
Gene name | mitochondrial pyruvate carrier 1 | |
Gene Alias | BRP44L | |
Cytomap | 6q27 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5TI65 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51660 | MPC1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.19e-18 | 7.14e-01 | -0.1954 |
51660 | MPC1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.23e-02 | 7.24e-01 | -0.2602 |
51660 | MPC1 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.43e-08 | 6.02e-01 | -0.1526 |
51660 | MPC1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.75e-06 | 6.72e-01 | -0.2061 |
51660 | MPC1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.91e-08 | -3.09e-01 | 0.3005 |
51660 | MPC1 | A002-C-010 | Human | Colorectum | FAP | 4.19e-03 | -1.87e-01 | 0.242 |
51660 | MPC1 | A015-C-203 | Human | Colorectum | FAP | 2.09e-10 | -2.66e-01 | -0.1294 |
51660 | MPC1 | A002-C-201 | Human | Colorectum | FAP | 3.25e-05 | -2.83e-01 | 0.0324 |
51660 | MPC1 | A002-C-203 | Human | Colorectum | FAP | 4.02e-03 | -2.08e-01 | 0.2786 |
51660 | MPC1 | A001-C-119 | Human | Colorectum | FAP | 2.01e-03 | -3.24e-01 | -0.1557 |
51660 | MPC1 | A001-C-108 | Human | Colorectum | FAP | 3.33e-06 | -2.44e-01 | -0.0272 |
51660 | MPC1 | A002-C-205 | Human | Colorectum | FAP | 1.33e-09 | -3.51e-01 | -0.1236 |
51660 | MPC1 | A001-C-104 | Human | Colorectum | FAP | 3.14e-04 | -2.17e-01 | 0.0184 |
51660 | MPC1 | A015-C-005 | Human | Colorectum | FAP | 5.97e-03 | -2.80e-01 | -0.0336 |
51660 | MPC1 | A015-C-006 | Human | Colorectum | FAP | 2.38e-03 | -2.60e-01 | -0.0994 |
51660 | MPC1 | A015-C-106 | Human | Colorectum | FAP | 9.04e-05 | -1.77e-01 | -0.0511 |
51660 | MPC1 | A002-C-114 | Human | Colorectum | FAP | 6.23e-06 | -3.14e-01 | -0.1561 |
51660 | MPC1 | A015-C-104 | Human | Colorectum | FAP | 2.64e-13 | -3.10e-01 | -0.1899 |
51660 | MPC1 | A001-C-014 | Human | Colorectum | FAP | 1.28e-05 | -2.29e-01 | 0.0135 |
51660 | MPC1 | A002-C-016 | Human | Colorectum | FAP | 1.53e-13 | -2.68e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000683916 | Prostate | BPH | mitochondrial transport | 79/3107 | 254/18723 | 6.77e-09 | 2.38e-07 | 79 |
GO:199054210 | Prostate | BPH | mitochondrial transmembrane transport | 34/3107 | 102/18723 | 2.63e-05 | 3.10e-04 | 34 |
GO:000683917 | Prostate | Tumor | mitochondrial transport | 84/3246 | 254/18723 | 7.17e-10 | 3.57e-08 | 84 |
GO:199054217 | Prostate | Tumor | mitochondrial transmembrane transport | 36/3246 | 102/18723 | 9.84e-06 | 1.43e-04 | 36 |
GO:000683927 | Skin | cSCC | mitochondrial transport | 124/4864 | 254/18723 | 3.54e-15 | 2.81e-13 | 124 |
GO:199054224 | Skin | cSCC | mitochondrial transmembrane transport | 43/4864 | 102/18723 | 2.68e-04 | 2.16e-03 | 43 |
GO:000683928 | Thyroid | PTC | mitochondrial transport | 150/5968 | 254/18723 | 2.76e-19 | 3.34e-17 | 150 |
GO:199054225 | Thyroid | PTC | mitochondrial transmembrane transport | 57/5968 | 102/18723 | 4.49e-07 | 7.38e-06 | 57 |
GO:000683929 | Thyroid | ATC | mitochondrial transport | 151/6293 | 254/18723 | 2.07e-17 | 2.14e-15 | 151 |
GO:199054226 | Thyroid | ATC | mitochondrial transmembrane transport | 57/6293 | 102/18723 | 3.05e-06 | 3.49e-05 | 57 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05415 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa054151 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa054152 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa054153 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa054154 | Colorectum | MSS | Diabetic cardiomyopathy | 106/1875 | 203/8465 | 2.47e-21 | 1.62e-19 | 9.92e-20 | 106 |
hsa054155 | Colorectum | MSS | Diabetic cardiomyopathy | 106/1875 | 203/8465 | 2.47e-21 | 1.62e-19 | 9.92e-20 | 106 |
hsa054158 | Colorectum | FAP | Diabetic cardiomyopathy | 70/1404 | 203/8465 | 2.62e-10 | 2.18e-08 | 1.33e-08 | 70 |
hsa054159 | Colorectum | FAP | Diabetic cardiomyopathy | 70/1404 | 203/8465 | 2.62e-10 | 2.18e-08 | 1.33e-08 | 70 |
hsa0541530 | Esophagus | HGIN | Diabetic cardiomyopathy | 80/1383 | 203/8465 | 1.35e-15 | 3.38e-14 | 2.69e-14 | 80 |
hsa05415114 | Esophagus | HGIN | Diabetic cardiomyopathy | 80/1383 | 203/8465 | 1.35e-15 | 3.38e-14 | 2.69e-14 | 80 |
hsa05415211 | Esophagus | ESCC | Diabetic cardiomyopathy | 146/4205 | 203/8465 | 5.81e-11 | 7.78e-10 | 3.99e-10 | 146 |
hsa0541538 | Esophagus | ESCC | Diabetic cardiomyopathy | 146/4205 | 203/8465 | 5.81e-11 | 7.78e-10 | 3.99e-10 | 146 |
hsa0541514 | Liver | Cirrhotic | Diabetic cardiomyopathy | 108/2530 | 203/8465 | 1.99e-12 | 4.41e-11 | 2.72e-11 | 108 |
hsa0541515 | Liver | Cirrhotic | Diabetic cardiomyopathy | 108/2530 | 203/8465 | 1.99e-12 | 4.41e-11 | 2.72e-11 | 108 |
hsa0541522 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0541532 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0541529 | Oral cavity | OSCC | Diabetic cardiomyopathy | 131/3704 | 203/8465 | 1.33e-09 | 1.49e-08 | 7.57e-09 | 131 |
hsa05415113 | Oral cavity | OSCC | Diabetic cardiomyopathy | 131/3704 | 203/8465 | 1.33e-09 | 1.49e-08 | 7.57e-09 | 131 |
hsa05415210 | Oral cavity | LP | Diabetic cardiomyopathy | 106/2418 | 203/8465 | 6.51e-13 | 1.36e-11 | 8.74e-12 | 106 |
hsa0541537 | Oral cavity | LP | Diabetic cardiomyopathy | 106/2418 | 203/8465 | 6.51e-13 | 1.36e-11 | 8.74e-12 | 106 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MPC1 | SNV | Missense_Mutation | c.110N>T | p.Pro37Leu | p.P37L | Q9Y5U8 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
MPC1 | SNV | Missense_Mutation | rs139776186 | c.253N>A | p.Ala85Thr | p.A85T | Q9Y5U8 | protein_coding | tolerated(0.36) | benign(0.027) | TCGA-E2-A15D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
MPC1 | SNV | Missense_Mutation | c.253N>T | p.Ala85Ser | p.A85S | Q9Y5U8 | protein_coding | tolerated(0.46) | benign(0.047) | TCGA-05-4244-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MPC1 | SNV | Missense_Mutation | rs767692880 | c.41N>A | p.Arg14Gln | p.R14Q | Q9Y5U8 | protein_coding | tolerated(0.09) | benign(0.009) | TCGA-CN-5374-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
MPC1 | SNV | Missense_Mutation | novel | c.84G>T | p.Trp28Cys | p.W28C | Q9Y5U8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-KU-A66S-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
MPC1 | insertion | Frame_Shift_Ins | novel | c.104_105insG | p.Leu36SerfsTer8 | p.L36Sfs*8 | Q9Y5U8 | protein_coding | TCGA-UF-A71D-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MPC1 | SNV | Missense_Mutation | rs753601697 | c.160N>T | p.Arg54Trp | p.R54W | Q9Y5U8 | protein_coding | deleterious(0) | benign(0.112) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
MPC1 | SNV | Missense_Mutation | rs387907237 | c.289N>T | p.Arg97Trp | p.R97W | Q9Y5U8 | protein_coding | deleterious(0.01) | possibly_damaging(0.741) | TCGA-VQ-AA6D-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR |
MPC1 | SNV | Missense_Mutation | rs753601697 | c.160N>T | p.Arg54Trp | p.R54W | Q9Y5U8 | protein_coding | deleterious(0) | benign(0.112) | TCGA-VQ-AA6D-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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