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Gene: MOGAT3 |
Gene summary for MOGAT3 |
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Gene information | Species | Human | Gene symbol | MOGAT3 | Gene ID | 346606 |
Gene name | monoacylglycerol O-acyltransferase 3 | |
Gene Alias | DC7 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q86VF5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
346606 | MOGAT3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.21e-12 | 8.04e-01 | -0.1808 |
346606 | MOGAT3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.61e-08 | 4.47e-01 | -0.1954 |
346606 | MOGAT3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.68e-02 | 8.22e-01 | -0.2602 |
346606 | MOGAT3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.08e-04 | 8.83e-01 | -0.2196 |
346606 | MOGAT3 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.38e-06 | 5.60e-01 | -0.1526 |
346606 | MOGAT3 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.23e-08 | 4.05e-01 | -0.1464 |
346606 | MOGAT3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.62e-02 | 5.61e-01 | -0.2061 |
346606 | MOGAT3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.94e-06 | 3.27e-01 | 0.3005 |
346606 | MOGAT3 | A002-C-010 | Human | Colorectum | FAP | 8.62e-04 | -1.34e-01 | 0.242 |
346606 | MOGAT3 | A002-C-201 | Human | Colorectum | FAP | 4.90e-02 | -1.33e-01 | 0.0324 |
346606 | MOGAT3 | A015-C-104 | Human | Colorectum | FAP | 1.11e-02 | -1.40e-01 | -0.1899 |
346606 | MOGAT3 | A002-C-116 | Human | Colorectum | FAP | 3.44e-03 | -1.34e-01 | -0.0452 |
346606 | MOGAT3 | Pat01-B | Human | Stomach | GC | 1.79e-29 | 5.41e-01 | 0.5754 |
346606 | MOGAT3 | Pat02-B | Human | Stomach | GC | 3.76e-03 | 1.34e-01 | 0.0368 |
346606 | MOGAT3 | Pat03-B | Human | Stomach | GC | 5.25e-15 | 3.35e-01 | 0.3693 |
346606 | MOGAT3 | Pat17-B | Human | Stomach | GC | 3.73e-12 | 3.48e-01 | 0.3109 |
346606 | MOGAT3 | SIM_1 | Human | Stomach | SIM | 3.52e-02 | 1.58e-01 | 0.3573 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066411 | Stomach | SIM | triglyceride metabolic process | 16/708 | 100/18723 | 1.03e-06 | 5.84e-05 | 16 |
GO:00066391 | Stomach | SIM | acylglycerol metabolic process | 16/708 | 128/18723 | 2.67e-05 | 8.13e-04 | 16 |
GO:00066381 | Stomach | SIM | neutral lipid metabolic process | 16/708 | 129/18723 | 2.95e-05 | 8.85e-04 | 16 |
GO:000606611 | Stomach | SIM | alcohol metabolic process | 25/708 | 353/18723 | 2.07e-03 | 2.22e-02 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00561 | Colorectum | AD | Glycerolipid metabolism | 24/2092 | 63/8465 | 1.25e-02 | 4.54e-02 | 2.90e-02 | 24 |
hsa005611 | Colorectum | AD | Glycerolipid metabolism | 24/2092 | 63/8465 | 1.25e-02 | 4.54e-02 | 2.90e-02 | 24 |
hsa04975 | Stomach | GC | Fat digestion and absorption | 14/708 | 43/8465 | 5.71e-06 | 8.30e-05 | 5.84e-05 | 14 |
hsa005614 | Stomach | GC | Glycerolipid metabolism | 12/708 | 63/8465 | 5.36e-03 | 3.01e-02 | 2.12e-02 | 12 |
hsa049751 | Stomach | GC | Fat digestion and absorption | 14/708 | 43/8465 | 5.71e-06 | 8.30e-05 | 5.84e-05 | 14 |
hsa0056111 | Stomach | GC | Glycerolipid metabolism | 12/708 | 63/8465 | 5.36e-03 | 3.01e-02 | 2.12e-02 | 12 |
hsa049752 | Stomach | SIM | Fat digestion and absorption | 12/465 | 43/8465 | 2.11e-06 | 3.05e-05 | 2.45e-05 | 12 |
hsa0056121 | Stomach | SIM | Glycerolipid metabolism | 9/465 | 63/8465 | 7.07e-03 | 4.30e-02 | 3.45e-02 | 9 |
hsa049753 | Stomach | SIM | Fat digestion and absorption | 12/465 | 43/8465 | 2.11e-06 | 3.05e-05 | 2.45e-05 | 12 |
hsa0056131 | Stomach | SIM | Glycerolipid metabolism | 9/465 | 63/8465 | 7.07e-03 | 4.30e-02 | 3.45e-02 | 9 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MOGAT3 | SNV | Missense_Mutation | c.567N>G | p.Ile189Met | p.I189M | Q86VF5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A04U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
MOGAT3 | SNV | Missense_Mutation | c.386N>G | p.Thr129Ser | p.T129S | Q86VF5 | protein_coding | deleterious(0.02) | probably_damaging(0.936) | TCGA-A2-A25E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD | |
MOGAT3 | SNV | Missense_Mutation | c.1010N>T | p.Cys337Phe | p.C337F | Q86VF5 | protein_coding | tolerated(0.48) | benign(0.04) | TCGA-E2-A14T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
MOGAT3 | deletion | Frame_Shift_Del | novel | c.87delN | p.Tyr29Ter | p.Y29* | Q86VF5 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
MOGAT3 | SNV | Missense_Mutation | rs201890499 | c.889G>A | p.Val297Ile | p.V297I | Q86VF5 | protein_coding | tolerated(0.14) | probably_damaging(0.959) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MOGAT3 | SNV | Missense_Mutation | novel | c.906N>A | p.His302Gln | p.H302Q | Q86VF5 | protein_coding | tolerated(0.82) | benign(0.007) | TCGA-C5-A8YT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
MOGAT3 | SNV | Missense_Mutation | rs771019638 | c.586N>A | p.Glu196Lys | p.E196K | Q86VF5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
MOGAT3 | SNV | Missense_Mutation | rs763725968 | c.898C>T | p.Arg300Cys | p.R300C | Q86VF5 | protein_coding | tolerated(0.55) | benign(0.005) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MOGAT3 | SNV | Missense_Mutation | c.830N>A | p.Ser277Tyr | p.S277Y | Q86VF5 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MOGAT3 | SNV | Missense_Mutation | rs139340331 | c.475G>A | p.Asp159Asn | p.D159N | Q86VF5 | protein_coding | deleterious(0.04) | possibly_damaging(0.617) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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