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Gene: MMP10 |
Gene summary for MMP10 |
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Gene information | Species | Human | Gene symbol | MMP10 | Gene ID | 4319 |
Gene name | matrix metallopeptidase 10 | |
Gene Alias | SL-2 | |
Cytomap | 11q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P09238 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4319 | MMP10 | Tumor | Human | Cervix | CC | 2.09e-07 | 3.86e-01 | 0.1241 |
4319 | MMP10 | sample3 | Human | Cervix | CC | 3.17e-17 | 5.62e-01 | 0.1387 |
4319 | MMP10 | T3 | Human | Cervix | CC | 1.12e-12 | 5.20e-01 | 0.1389 |
4319 | MMP10 | LZE8T | Human | Esophagus | ESCC | 8.46e-25 | 3.27e+00 | 0.067 |
4319 | MMP10 | P2T-E | Human | Esophagus | ESCC | 6.83e-07 | -1.01e-01 | 0.1177 |
4319 | MMP10 | P8T-E | Human | Esophagus | ESCC | 3.87e-32 | 2.95e+00 | 0.0889 |
4319 | MMP10 | P11T-E | Human | Esophagus | ESCC | 8.73e-06 | 2.92e+00 | 0.1426 |
4319 | MMP10 | P26T-E | Human | Esophagus | ESCC | 5.62e-35 | 3.23e+00 | 0.1276 |
4319 | MMP10 | P31T-E | Human | Esophagus | ESCC | 2.05e-05 | 1.34e+00 | 0.1251 |
4319 | MMP10 | P37T-E | Human | Esophagus | ESCC | 9.84e-23 | 1.62e+00 | 0.1371 |
4319 | MMP10 | P54T-E | Human | Esophagus | ESCC | 3.18e-08 | 1.89e+00 | 0.0975 |
4319 | MMP10 | P61T-E | Human | Esophagus | ESCC | 3.81e-14 | 1.49e+00 | 0.099 |
4319 | MMP10 | P62T-E | Human | Esophagus | ESCC | 5.45e-04 | 1.86e+00 | 0.1302 |
4319 | MMP10 | P65T-E | Human | Esophagus | ESCC | 2.53e-07 | 9.40e-01 | 0.0978 |
4319 | MMP10 | P74T-E | Human | Esophagus | ESCC | 4.87e-24 | 3.58e+00 | 0.1479 |
4319 | MMP10 | P83T-E | Human | Esophagus | ESCC | 6.63e-04 | 1.11e+00 | 0.1738 |
4319 | MMP10 | P89T-E | Human | Esophagus | ESCC | 4.07e-11 | 4.89e+00 | 0.1752 |
4319 | MMP10 | P107T-E | Human | Esophagus | ESCC | 5.33e-49 | 4.41e+00 | 0.171 |
4319 | MMP10 | P126T-E | Human | Esophagus | ESCC | 2.43e-05 | 2.74e+00 | 0.1125 |
4319 | MMP10 | P130T-E | Human | Esophagus | ESCC | 1.72e-15 | 1.40e+00 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00452291 | Prostate | BPH | external encapsulating structure organization | 66/3107 | 304/18723 | 1.15e-02 | 4.66e-02 | 66 |
GO:0022411112 | Skin | cSCC | cellular component disassembly | 201/4864 | 443/18723 | 4.09e-19 | 5.69e-17 | 201 |
GO:002241124 | Thyroid | ATC | cellular component disassembly | 248/6293 | 443/18723 | 1.34e-22 | 3.69e-20 | 248 |
GO:003019812 | Thyroid | ATC | extracellular matrix organization | 152/6293 | 301/18723 | 8.63e-10 | 2.24e-08 | 152 |
GO:004306212 | Thyroid | ATC | extracellular structure organization | 152/6293 | 302/18723 | 1.17e-09 | 2.94e-08 | 152 |
GO:004522912 | Thyroid | ATC | external encapsulating structure organization | 152/6293 | 304/18723 | 2.11e-09 | 5.08e-08 | 152 |
GO:00329633 | Thyroid | ATC | collagen metabolic process | 52/6293 | 104/18723 | 3.94e-04 | 2.38e-03 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MMP10 | SNV | Missense_Mutation | novel | c.742N>C | p.Phe248Leu | p.F248L | P09238 | protein_coding | tolerated(0.15) | benign(0.03) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |
MMP10 | SNV | Missense_Mutation | c.283G>C | p.Asp95His | p.D95H | P09238 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MMP10 | SNV | Missense_Mutation | c.574N>A | p.Gly192Arg | p.G192R | P09238 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
MMP10 | insertion | Nonsense_Mutation | novel | c.148_149insCCAGCATTTTGGGAGGCCAAGTTGGGT | p.Gln50delinsProSerIleLeuGlyGlyGlnValGlyTer | p.Q50delinsPSILGGQVG* | P09238 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MMP10 | SNV | Missense_Mutation | c.1001N>G | p.Ser334Cys | p.S334C | P09238 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
MMP10 | SNV | Missense_Mutation | novel | c.595N>A | p.Asp199Asn | p.D199N | P09238 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
MMP10 | SNV | Missense_Mutation | novel | c.466G>C | p.Ala156Pro | p.A156P | P09238 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MMP10 | SNV | Missense_Mutation | c.259N>T | p.Arg87Cys | p.R87C | P09238 | protein_coding | deleterious(0.01) | possibly_damaging(0.712) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
MMP10 | SNV | Missense_Mutation | novel | c.749N>G | p.Leu250Arg | p.L250R | P09238 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MMP10 | SNV | Missense_Mutation | c.259N>T | p.Arg87Cys | p.R87C | P09238 | protein_coding | deleterious(0.01) | possibly_damaging(0.712) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4319 | MMP10 | DRUGGABLE GENOME, ENZYME, PROTEASE | inhibitor | 249565939 |
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