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Gene: METTL5 |
Gene summary for METTL5 |
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Gene information | Species | Human | Gene symbol | METTL5 | Gene ID | 29081 |
Gene name | methyltransferase 5, N6-adenosine | |
Gene Alias | HSPC133 | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000154 | UniProtAcc | Q9NRN9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29081 | METTL5 | LZE2T | Human | Esophagus | ESCC | 4.47e-07 | 1.18e+00 | 0.082 |
29081 | METTL5 | LZE3D | Human | Esophagus | HGIN | 1.10e-04 | 5.27e-01 | 0.0668 |
29081 | METTL5 | LZE4T | Human | Esophagus | ESCC | 7.07e-16 | 7.03e-01 | 0.0811 |
29081 | METTL5 | LZE5T | Human | Esophagus | ESCC | 1.67e-02 | 3.70e-01 | 0.0514 |
29081 | METTL5 | LZE7T | Human | Esophagus | ESCC | 1.24e-10 | 9.57e-01 | 0.0667 |
29081 | METTL5 | LZE8T | Human | Esophagus | ESCC | 4.85e-06 | 3.80e-01 | 0.067 |
29081 | METTL5 | LZE20T | Human | Esophagus | ESCC | 5.33e-05 | 4.66e-01 | 0.0662 |
29081 | METTL5 | LZE22D1 | Human | Esophagus | HGIN | 3.57e-05 | 3.68e-01 | 0.0595 |
29081 | METTL5 | LZE22T | Human | Esophagus | ESCC | 1.43e-07 | 6.91e-01 | 0.068 |
29081 | METTL5 | LZE24T | Human | Esophagus | ESCC | 9.72e-25 | 9.11e-01 | 0.0596 |
29081 | METTL5 | LZE6T | Human | Esophagus | ESCC | 3.80e-12 | 7.25e-01 | 0.0845 |
29081 | METTL5 | P1T-E | Human | Esophagus | ESCC | 2.47e-07 | 6.60e-01 | 0.0875 |
29081 | METTL5 | P2T-E | Human | Esophagus | ESCC | 5.30e-28 | 6.76e-01 | 0.1177 |
29081 | METTL5 | P4T-E | Human | Esophagus | ESCC | 1.13e-56 | 1.68e+00 | 0.1323 |
29081 | METTL5 | P5T-E | Human | Esophagus | ESCC | 4.00e-70 | 1.34e+00 | 0.1327 |
29081 | METTL5 | P8T-E | Human | Esophagus | ESCC | 1.60e-34 | 7.67e-01 | 0.0889 |
29081 | METTL5 | P9T-E | Human | Esophagus | ESCC | 4.14e-66 | 2.01e+00 | 0.1131 |
29081 | METTL5 | P10T-E | Human | Esophagus | ESCC | 2.00e-69 | 1.41e+00 | 0.116 |
29081 | METTL5 | P11T-E | Human | Esophagus | ESCC | 8.41e-19 | 1.06e+00 | 0.1426 |
29081 | METTL5 | P12T-E | Human | Esophagus | ESCC | 1.74e-62 | 1.28e+00 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00488638 | Esophagus | ESCC | stem cell differentiation | 122/8552 | 206/18723 | 5.95e-05 | 4.59e-04 | 122 |
GO:0000154 | Esophagus | ESCC | rRNA modification | 26/8552 | 37/18723 | 2.16e-03 | 9.62e-03 | 26 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:000636412 | Liver | Cirrhotic | rRNA processing | 115/4634 | 225/18723 | 1.12e-17 | 1.64e-15 | 115 |
GO:00160724 | Liver | Cirrhotic | rRNA metabolic process | 119/4634 | 236/18723 | 1.19e-17 | 1.70e-15 | 119 |
GO:000641712 | Liver | Cirrhotic | regulation of translation | 194/4634 | 468/18723 | 7.28e-16 | 8.79e-14 | 194 |
GO:00457277 | Liver | Cirrhotic | positive regulation of translation | 71/4634 | 136/18723 | 4.99e-12 | 3.52e-10 | 71 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:003425012 | Liver | Cirrhotic | positive regulation of cellular amide metabolic process | 78/4634 | 162/18723 | 8.62e-11 | 4.66e-09 | 78 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:004886311 | Liver | Cirrhotic | stem cell differentiation | 66/4634 | 206/18723 | 1.06e-02 | 4.68e-02 | 66 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
METTL5 | SNV | Missense_Mutation | c.525N>C | p.Lys175Asn | p.K175N | Q9NRN9 | protein_coding | tolerated(0.23) | benign(0.021) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
METTL5 | SNV | Missense_Mutation | c.511N>A | p.Glu171Lys | p.E171K | Q9NRN9 | protein_coding | tolerated(0.14) | benign(0.05) | TCGA-D8-A146-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
METTL5 | insertion | Nonsense_Mutation | novel | c.24_25insGTGCTGAGATTACAGGCATGAGCCACTGAGG | p.Leu9ValfsTer7 | p.L9Vfs*7 | Q9NRN9 | protein_coding | TCGA-A7-A0D9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | ||
METTL5 | SNV | Missense_Mutation | novel | c.318N>T | p.Gln106His | p.Q106H | Q9NRN9 | protein_coding | tolerated(0.12) | benign(0.125) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD |
METTL5 | SNV | Missense_Mutation | novel | c.317N>T | p.Gln106Leu | p.Q106L | Q9NRN9 | protein_coding | tolerated(0.28) | benign(0.034) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD |
METTL5 | SNV | Missense_Mutation | novel | c.241N>C | p.Asp81His | p.D81H | Q9NRN9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-MY-A913-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
METTL5 | SNV | Missense_Mutation | c.84G>T | p.Gln28His | p.Q28H | Q9NRN9 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
METTL5 | SNV | Missense_Mutation | c.85T>G | p.Tyr29Asp | p.Y29D | Q9NRN9 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3975-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
METTL5 | SNV | Missense_Mutation | c.280N>A | p.Ala94Thr | p.A94T | Q9NRN9 | protein_coding | tolerated(0.27) | benign(0.05) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
METTL5 | SNV | Missense_Mutation | c.64N>G | p.Pro22Ala | p.P22A | Q9NRN9 | protein_coding | deleterious(0.03) | benign(0.323) | TCGA-AG-3878-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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