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Gene: METAP2 |
Gene summary for METAP2 |
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Gene information | Species | Human | Gene symbol | METAP2 | Gene ID | 10988 |
Gene name | methionyl aminopeptidase 2 | |
Gene Alias | MAP2 | |
Cytomap | 12q22 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | P50579 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10988 | METAP2 | AEH-subject2 | Human | Endometrium | AEH | 1.83e-07 | -1.81e-01 | -0.2525 |
10988 | METAP2 | AEH-subject3 | Human | Endometrium | AEH | 2.57e-08 | -1.82e-01 | -0.2576 |
10988 | METAP2 | AEH-subject4 | Human | Endometrium | AEH | 4.09e-05 | -2.59e-01 | -0.2657 |
10988 | METAP2 | AEH-subject5 | Human | Endometrium | AEH | 4.32e-03 | -2.64e-01 | -0.2953 |
10988 | METAP2 | EEC-subject1 | Human | Endometrium | EEC | 9.56e-08 | -2.77e-01 | -0.2682 |
10988 | METAP2 | EEC-subject2 | Human | Endometrium | EEC | 1.24e-06 | -1.69e-01 | -0.2607 |
10988 | METAP2 | EEC-subject3 | Human | Endometrium | EEC | 1.66e-24 | -1.69e-01 | -0.2525 |
10988 | METAP2 | EEC-subject4 | Human | Endometrium | EEC | 1.30e-10 | -3.56e-01 | -0.2571 |
10988 | METAP2 | EEC-subject5 | Human | Endometrium | EEC | 3.97e-02 | -2.42e-01 | -0.249 |
10988 | METAP2 | GSM5276934 | Human | Endometrium | EEC | 2.14e-03 | 1.19e-01 | -0.0913 |
10988 | METAP2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.00e-29 | -1.08e-01 | -0.1869 |
10988 | METAP2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.38e-31 | -5.08e-02 | -0.1875 |
10988 | METAP2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.35e-33 | -1.97e-01 | -0.1883 |
10988 | METAP2 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.12e-27 | 1.96e-02 | -0.1934 |
10988 | METAP2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 6.51e-39 | -1.66e-01 | -0.1917 |
10988 | METAP2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 3.58e-44 | -9.72e-02 | -0.1916 |
10988 | METAP2 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.27e-03 | -2.05e-01 | -0.1269 |
10988 | METAP2 | LZE4T | Human | Esophagus | ESCC | 5.02e-24 | 1.30e-01 | 0.0811 |
10988 | METAP2 | LZE7T | Human | Esophagus | ESCC | 3.35e-06 | 8.32e-01 | 0.0667 |
10988 | METAP2 | LZE8T | Human | Esophagus | ESCC | 5.09e-03 | 1.25e-01 | 0.067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005160419 | Skin | cSCC | protein maturation | 117/4864 | 294/18723 | 1.27e-07 | 2.93e-06 | 117 |
GO:00164858 | Skin | cSCC | protein processing | 79/4864 | 225/18723 | 1.43e-03 | 9.02e-03 | 79 |
GO:005160420 | Thyroid | PTC | protein maturation | 132/5968 | 294/18723 | 1.71e-06 | 2.39e-05 | 132 |
GO:00164859 | Thyroid | PTC | protein processing | 95/5968 | 225/18723 | 6.60e-04 | 4.15e-03 | 95 |
GO:0051604110 | Thyroid | ATC | protein maturation | 136/6293 | 294/18723 | 4.00e-06 | 4.42e-05 | 136 |
GO:001648515 | Thyroid | ATC | protein processing | 100/6293 | 225/18723 | 4.39e-04 | 2.62e-03 | 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
METAP2 | SNV | Missense_Mutation | c.758N>T | p.Gly253Val | p.G253V | P50579 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A06U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
METAP2 | SNV | Missense_Mutation | rs752983315 | c.614G>A | p.Arg205His | p.R205H | P50579 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
METAP2 | SNV | Missense_Mutation | c.1051N>A | p.Glu351Lys | p.E351K | P50579 | protein_coding | deleterious(0.01) | possibly_damaging(0.822) | TCGA-GM-A2DO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR | |
METAP2 | SNV | Missense_Mutation | novel | c.1253N>A | p.Arg418Lys | p.R418K | P50579 | protein_coding | deleterious(0.04) | possibly_damaging(0.769) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD |
METAP2 | SNV | Missense_Mutation | novel | c.281N>A | p.Gly94Glu | p.G94E | P50579 | protein_coding | tolerated(0.28) | benign(0.025) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
METAP2 | SNV | Missense_Mutation | novel | c.797N>T | p.Thr266Ile | p.T266I | P50579 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
METAP2 | SNV | Missense_Mutation | novel | c.463N>C | p.Lys155Gln | p.K155Q | P50579 | protein_coding | deleterious(0) | benign(0.049) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
METAP2 | SNV | Missense_Mutation | c.473N>C | p.Leu158Ser | p.L158S | P50579 | protein_coding | deleterious(0.02) | benign(0.024) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
METAP2 | SNV | Missense_Mutation | c.908N>T | p.Ala303Val | p.A303V | P50579 | protein_coding | deleterious(0.05) | benign(0.028) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
METAP2 | SNV | Missense_Mutation | c.223G>A | p.Ala75Thr | p.A75T | P50579 | protein_coding | tolerated_low_confidence(0.36) | benign(0) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10988 | METAP2 | ENZYME, DRUGGABLE GENOME, KINASE, PROTEASE | PPI-2458 | PPI-2458 | ||
10988 | METAP2 | ENZYME, DRUGGABLE GENOME, KINASE, PROTEASE | PPI-2458 | PPI-2458 | ||
10988 | METAP2 | ENZYME, DRUGGABLE GENOME, KINASE, PROTEASE | BELORANIB | BELORANIB | ||
10988 | METAP2 | ENZYME, DRUGGABLE GENOME, KINASE, PROTEASE | Beloranib | BELORANIB | ||
10988 | METAP2 | ENZYME, DRUGGABLE GENOME, KINASE, PROTEASE | XMT-1107 | |||
10988 | METAP2 | ENZYME, DRUGGABLE GENOME, KINASE, PROTEASE | D-Methionine | |||
10988 | METAP2 | ENZYME, DRUGGABLE GENOME, KINASE, PROTEASE | inhibitor | CHEMBL2103847 | TOSEDOSTAT | |
10988 | METAP2 | ENZYME, DRUGGABLE GENOME, KINASE, PROTEASE | inhibitor | 252166655 | BELORANIB | |
10988 | METAP2 | ENZYME, DRUGGABLE GENOME, KINASE, PROTEASE | inhibitor | 178103100 | ||
10988 | METAP2 | ENZYME, DRUGGABLE GENOME, KINASE, PROTEASE | M8891 |
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