![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MED25 |
Gene summary for MED25 |
![]() |
Gene information | Species | Human | Gene symbol | MED25 | Gene ID | 81857 |
Gene name | mediator complex subunit 25 | |
Gene Alias | ACID1 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q71SY5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81857 | MED25 | LZE4T | Human | Esophagus | ESCC | 5.14e-05 | 1.51e-01 | 0.0811 |
81857 | MED25 | LZE7T | Human | Esophagus | ESCC | 1.79e-09 | 4.35e-01 | 0.0667 |
81857 | MED25 | LZE8T | Human | Esophagus | ESCC | 2.10e-05 | 2.25e-01 | 0.067 |
81857 | MED25 | LZE20T | Human | Esophagus | ESCC | 3.00e-04 | 1.26e-01 | 0.0662 |
81857 | MED25 | LZE22D1 | Human | Esophagus | HGIN | 5.16e-04 | 1.67e-01 | 0.0595 |
81857 | MED25 | LZE22T | Human | Esophagus | ESCC | 7.38e-03 | 2.91e-01 | 0.068 |
81857 | MED25 | LZE24T | Human | Esophagus | ESCC | 7.11e-10 | 3.85e-01 | 0.0596 |
81857 | MED25 | LZE6T | Human | Esophagus | ESCC | 1.37e-03 | 1.64e-01 | 0.0845 |
81857 | MED25 | P1T-E | Human | Esophagus | ESCC | 3.44e-08 | 4.24e-01 | 0.0875 |
81857 | MED25 | P2T-E | Human | Esophagus | ESCC | 2.83e-16 | 3.53e-01 | 0.1177 |
81857 | MED25 | P4T-E | Human | Esophagus | ESCC | 5.37e-10 | 1.89e-01 | 0.1323 |
81857 | MED25 | P5T-E | Human | Esophagus | ESCC | 1.57e-06 | 1.60e-01 | 0.1327 |
81857 | MED25 | P8T-E | Human | Esophagus | ESCC | 7.09e-45 | 8.83e-01 | 0.0889 |
81857 | MED25 | P9T-E | Human | Esophagus | ESCC | 1.60e-11 | 1.69e-01 | 0.1131 |
81857 | MED25 | P10T-E | Human | Esophagus | ESCC | 2.32e-13 | 2.39e-01 | 0.116 |
81857 | MED25 | P11T-E | Human | Esophagus | ESCC | 8.07e-12 | 5.37e-01 | 0.1426 |
81857 | MED25 | P12T-E | Human | Esophagus | ESCC | 1.63e-14 | 3.47e-01 | 0.1122 |
81857 | MED25 | P15T-E | Human | Esophagus | ESCC | 2.80e-25 | 4.73e-01 | 0.1149 |
81857 | MED25 | P16T-E | Human | Esophagus | ESCC | 7.59e-07 | 1.28e-01 | 0.1153 |
81857 | MED25 | P17T-E | Human | Esophagus | ESCC | 2.57e-07 | 3.85e-01 | 0.1278 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048144 | Liver | Cirrhotic | fibroblast proliferation | 33/4634 | 81/18723 | 1.09e-03 | 7.59e-03 | 33 |
GO:004325422 | Liver | HCC | regulation of protein-containing complex assembly | 264/7958 | 428/18723 | 5.47e-16 | 4.39e-14 | 264 |
GO:005109822 | Liver | HCC | regulation of binding | 225/7958 | 363/18723 | 3.78e-14 | 2.37e-12 | 225 |
GO:003133412 | Liver | HCC | positive regulation of protein-containing complex assembly | 150/7958 | 237/18723 | 7.35e-11 | 2.63e-09 | 150 |
GO:005109922 | Liver | HCC | positive regulation of binding | 108/7958 | 173/18723 | 9.22e-08 | 1.83e-06 | 108 |
GO:004325420 | Oral cavity | OSCC | regulation of protein-containing complex assembly | 255/7305 | 428/18723 | 2.94e-18 | 3.15e-16 | 255 |
GO:003133420 | Oral cavity | OSCC | positive regulation of protein-containing complex assembly | 153/7305 | 237/18723 | 1.18e-15 | 8.33e-14 | 153 |
GO:005109820 | Oral cavity | OSCC | regulation of binding | 212/7305 | 363/18723 | 3.88e-14 | 2.15e-12 | 212 |
GO:005109920 | Oral cavity | OSCC | positive regulation of binding | 105/7305 | 173/18723 | 5.88e-09 | 1.26e-07 | 105 |
GO:00481446 | Oral cavity | OSCC | fibroblast proliferation | 49/7305 | 81/18723 | 7.27e-05 | 5.72e-04 | 49 |
GO:00481457 | Oral cavity | OSCC | regulation of fibroblast proliferation | 48/7305 | 80/18723 | 1.14e-04 | 8.35e-04 | 48 |
GO:0051098113 | Thyroid | PTC | regulation of binding | 195/5968 | 363/18723 | 3.21e-18 | 3.37e-16 | 195 |
GO:0043254113 | Thyroid | PTC | regulation of protein-containing complex assembly | 215/5968 | 428/18723 | 1.23e-15 | 9.09e-14 | 215 |
GO:0051099113 | Thyroid | PTC | positive regulation of binding | 100/5968 | 173/18723 | 1.56e-12 | 6.96e-11 | 100 |
GO:0031334113 | Thyroid | PTC | positive regulation of protein-containing complex assembly | 121/5968 | 237/18723 | 5.70e-10 | 1.81e-08 | 121 |
GO:004814516 | Thyroid | PTC | regulation of fibroblast proliferation | 41/5968 | 80/18723 | 2.43e-04 | 1.75e-03 | 41 |
GO:004814416 | Thyroid | PTC | fibroblast proliferation | 41/5968 | 81/18723 | 3.41e-04 | 2.35e-03 | 41 |
GO:005109834 | Thyroid | ATC | regulation of binding | 203/6293 | 363/18723 | 1.18e-18 | 1.55e-16 | 203 |
GO:0043254210 | Thyroid | ATC | regulation of protein-containing complex assembly | 225/6293 | 428/18723 | 2.72e-16 | 2.33e-14 | 225 |
GO:005109934 | Thyroid | ATC | positive regulation of binding | 103/6293 | 173/18723 | 2.19e-12 | 9.05e-11 | 103 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MED25 | SNV | Missense_Mutation | rs775622130 | c.751N>A | p.Ala251Thr | p.A251T | Q71SY5 | protein_coding | tolerated(0.38) | benign(0.041) | TCGA-D8-A1XF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
MED25 | SNV | Missense_Mutation | c.1271C>T | p.Thr424Met | p.T424M | Q71SY5 | protein_coding | deleterious(0) | benign(0.375) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD | |
MED25 | SNV | Missense_Mutation | c.213N>G | p.Phe71Leu | p.F71L | Q71SY5 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-E2-A14Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | PD | |
MED25 | SNV | Missense_Mutation | novel | c.82N>G | p.Leu28Val | p.L28V | Q71SY5 | protein_coding | tolerated(0.07) | probably_damaging(0.992) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
MED25 | SNV | Missense_Mutation | c.1864N>T | p.Pro622Ser | p.P622S | Q71SY5 | protein_coding | tolerated_low_confidence(0.07) | benign(0.026) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
MED25 | SNV | Missense_Mutation | c.1677N>T | p.Met559Ile | p.M559I | Q71SY5 | protein_coding | tolerated(0.13) | benign(0) | TCGA-JW-A5VI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | topotecan | PD | |
MED25 | SNV | Missense_Mutation | rs371817340 | c.748N>A | p.Ala250Thr | p.A250T | Q71SY5 | protein_coding | tolerated(0.48) | benign(0.034) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MED25 | SNV | Missense_Mutation | c.1528N>A | p.Val510Met | p.V510M | Q71SY5 | protein_coding | deleterious(0.03) | probably_damaging(0.984) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
MED25 | SNV | Missense_Mutation | c.1224N>C | p.Trp408Cys | p.W408C | Q71SY5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MED25 | SNV | Missense_Mutation | rs781140315 | c.418C>T | p.Arg140Trp | p.R140W | Q71SY5 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |