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Gene: MATR3 |
Gene summary for MATR3 |
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Gene information | Species | Human | Gene symbol | MATR3 | Gene ID | 9782 |
Gene name | matrin 3 | |
Gene Alias | ALS21 | |
Cytomap | 5q31.2 | |
Gene Type | protein-coding | GO ID | GO:0002218 | UniProtAcc | A0A0R4J2E8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9782 | MATR3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.67e-02 | -1.27e-01 | 0.0155 |
9782 | MATR3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.53e-02 | -1.27e-01 | -0.1954 |
9782 | MATR3 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.07e-04 | -1.27e-01 | -0.1464 |
9782 | MATR3 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.07e-04 | -1.27e-01 | -0.1001 |
9782 | MATR3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.07e-04 | -1.27e-01 | 0.0674 |
9782 | MATR3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.45e-30 | 9.31e-01 | 0.294 |
9782 | MATR3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 8.78e-08 | 1.28e+00 | 0.3487 |
9782 | MATR3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.15e-15 | 8.35e-01 | 0.281 |
9782 | MATR3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.58e-11 | 5.17e-01 | 0.3859 |
9782 | MATR3 | A015-C-203 | Human | Colorectum | FAP | 1.92e-04 | -1.27e-01 | -0.1294 |
9782 | MATR3 | A001-C-108 | Human | Colorectum | FAP | 2.28e-02 | -9.92e-02 | -0.0272 |
9782 | MATR3 | A002-C-205 | Human | Colorectum | FAP | 1.15e-02 | -1.27e-01 | -0.1236 |
9782 | MATR3 | A015-C-104 | Human | Colorectum | FAP | 1.92e-04 | -1.15e-01 | -0.1899 |
9782 | MATR3 | A002-C-116 | Human | Colorectum | FAP | 1.94e-02 | -8.43e-02 | -0.0452 |
9782 | MATR3 | A018-E-020 | Human | Colorectum | FAP | 3.96e-02 | -1.27e-01 | -0.2034 |
9782 | MATR3 | LZE4T | Human | Esophagus | ESCC | 3.28e-06 | -4.83e-01 | 0.0811 |
9782 | MATR3 | LZE8T | Human | Esophagus | ESCC | 7.80e-05 | -5.37e-01 | 0.067 |
9782 | MATR3 | LZE20T | Human | Esophagus | ESCC | 3.16e-06 | -5.50e-01 | 0.0662 |
9782 | MATR3 | LZE22D1 | Human | Esophagus | HGIN | 1.12e-02 | -5.50e-01 | 0.0595 |
9782 | MATR3 | LZE24T | Human | Esophagus | ESCC | 6.60e-09 | -5.19e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00032815 | Skin | AK | ventricular septum development | 16/1910 | 71/18723 | 1.80e-03 | 1.24e-02 | 16 |
GO:00032054 | Skin | AK | cardiac chamber development | 28/1910 | 161/18723 | 3.44e-03 | 2.09e-02 | 28 |
GO:00031704 | Skin | AK | heart valve development | 14/1910 | 65/18723 | 5.22e-03 | 2.91e-02 | 14 |
GO:00022535 | Skin | AK | activation of immune response | 54/1910 | 375/18723 | 5.90e-03 | 3.20e-02 | 54 |
GO:00450886 | Skin | AK | regulation of innate immune response | 34/1910 | 218/18723 | 8.06e-03 | 4.06e-02 | 34 |
GO:00313496 | Skin | AK | positive regulation of defense response | 41/1910 | 278/18723 | 1.02e-02 | 4.86e-02 | 41 |
GO:003210315 | Skin | SCCIS | positive regulation of response to external stimulus | 51/919 | 427/18723 | 3.99e-09 | 1.76e-06 | 51 |
GO:000283113 | Skin | SCCIS | regulation of response to biotic stimulus | 32/919 | 327/18723 | 1.67e-04 | 3.31e-03 | 32 |
GO:000225314 | Skin | SCCIS | activation of immune response | 33/919 | 375/18723 | 8.93e-04 | 1.15e-02 | 33 |
GO:003134913 | Skin | SCCIS | positive regulation of defense response | 26/919 | 278/18723 | 1.28e-03 | 1.49e-02 | 26 |
GO:00028333 | Skin | SCCIS | positive regulation of response to biotic stimulus | 17/919 | 168/18723 | 3.77e-03 | 3.27e-02 | 17 |
GO:000283122 | Skin | cSCC | regulation of response to biotic stimulus | 112/4864 | 327/18723 | 5.00e-04 | 3.76e-03 | 112 |
GO:004508812 | Skin | cSCC | regulation of innate immune response | 75/4864 | 218/18723 | 3.40e-03 | 1.84e-02 | 75 |
GO:00321039 | Thyroid | HT | positive regulation of response to external stimulus | 55/1272 | 427/18723 | 3.50e-06 | 1.16e-04 | 55 |
GO:00313497 | Thyroid | HT | positive regulation of defense response | 40/1272 | 278/18723 | 5.40e-06 | 1.66e-04 | 40 |
GO:00022536 | Thyroid | HT | activation of immune response | 47/1272 | 375/18723 | 3.55e-05 | 7.40e-04 | 47 |
GO:000283110 | Thyroid | HT | regulation of response to biotic stimulus | 36/1272 | 327/18723 | 2.91e-03 | 2.36e-02 | 36 |
GO:00028334 | Thyroid | HT | positive regulation of response to biotic stimulus | 21/1272 | 168/18723 | 4.98e-03 | 3.36e-02 | 21 |
GO:00032816 | Thyroid | HT | ventricular septum development | 11/1272 | 71/18723 | 8.09e-03 | 4.73e-02 | 11 |
GO:00032794 | Thyroid | PTC | cardiac septum development | 54/5968 | 103/18723 | 1.17e-05 | 1.29e-04 | 54 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050144 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa050145 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa050146 | Colorectum | MSI-H | Amyotrophic lateral sclerosis | 95/797 | 364/8465 | 2.31e-21 | 1.50e-19 | 1.26e-19 | 95 |
hsa050147 | Colorectum | MSI-H | Amyotrophic lateral sclerosis | 95/797 | 364/8465 | 2.31e-21 | 1.50e-19 | 1.26e-19 | 95 |
hsa050148 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
hsa050149 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
hsa0501430 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
hsa05014113 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0501427 | Prostate | Tumor | Amyotrophic lateral sclerosis | 155/1791 | 364/8465 | 3.41e-21 | 1.13e-19 | 6.99e-20 | 155 |
hsa0501436 | Prostate | Tumor | Amyotrophic lateral sclerosis | 155/1791 | 364/8465 | 3.41e-21 | 1.13e-19 | 6.99e-20 | 155 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MATR3 | SNV | Missense_Mutation | c.1885G>A | p.Glu629Lys | p.E629K | protein_coding | tolerated(0.07) | benign(0) | TCGA-E2-A1B1-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Other, specify in notesbiphosphonate | zoledronic | SD | ||
MATR3 | SNV | Missense_Mutation | novel | c.325N>G | p.Ser109Gly | p.S109G | protein_coding | deleterious(0.03) | benign(0.025) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
MATR3 | insertion | Frame_Shift_Ins | novel | c.887_888insGTGGC | p.Cys296TrpfsTer118 | p.C296Wfs*118 | protein_coding | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
MATR3 | SNV | Missense_Mutation | c.1238N>G | p.Tyr413Cys | p.Y413C | protein_coding | tolerated(0.17) | benign(0.431) | TCGA-C5-A7CJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
MATR3 | SNV | Missense_Mutation | novel | c.554N>C | p.Arg185Thr | p.R185T | protein_coding | deleterious(0.01) | probably_damaging(0.91) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MATR3 | SNV | Missense_Mutation | novel | c.994N>A | p.Asp332Asn | p.D332N | protein_coding | tolerated(0.4) | probably_damaging(0.956) | TCGA-VS-A952-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
MATR3 | SNV | Missense_Mutation | c.361N>A | p.Asp121Asn | p.D121N | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
MATR3 | SNV | Missense_Mutation | novel | c.814G>A | p.Ala272Thr | p.A272T | protein_coding | tolerated(0.18) | benign(0.351) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MATR3 | SNV | Missense_Mutation | novel | c.2248N>G | p.Asn750Asp | p.N750D | protein_coding | tolerated(0.78) | benign(0) | TCGA-AA-3968-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MATR3 | SNV | Missense_Mutation | c.786G>T | p.Glu262Asp | p.E262D | protein_coding | tolerated(0.41) | possibly_damaging(0.899) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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