![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MARCKSL1 |
Gene summary for MARCKSL1 |
![]() |
Gene information | Species | Human | Gene symbol | MARCKSL1 | Gene ID | 65108 |
Gene name | MARCKS like 1 | |
Gene Alias | F52 | |
Cytomap | 1p35.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | P49006 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65108 | MARCKSL1 | GSM4909281 | Human | Breast | IDC | 5.44e-52 | 6.68e-01 | 0.21 |
65108 | MARCKSL1 | GSM4909282 | Human | Breast | IDC | 6.27e-23 | 4.98e-01 | -0.0288 |
65108 | MARCKSL1 | GSM4909285 | Human | Breast | IDC | 1.27e-78 | 8.00e-01 | 0.21 |
65108 | MARCKSL1 | GSM4909286 | Human | Breast | IDC | 5.08e-89 | 8.75e-01 | 0.1081 |
65108 | MARCKSL1 | GSM4909288 | Human | Breast | IDC | 7.07e-21 | 6.13e-01 | 0.0988 |
65108 | MARCKSL1 | GSM4909289 | Human | Breast | IDC | 2.67e-10 | 5.84e-01 | 0.1064 |
65108 | MARCKSL1 | GSM4909290 | Human | Breast | IDC | 1.60e-11 | 4.39e-01 | 0.2096 |
65108 | MARCKSL1 | GSM4909293 | Human | Breast | IDC | 1.71e-54 | 6.66e-01 | 0.1581 |
65108 | MARCKSL1 | GSM4909294 | Human | Breast | IDC | 2.13e-60 | 6.33e-01 | 0.2022 |
65108 | MARCKSL1 | GSM4909296 | Human | Breast | IDC | 1.15e-12 | -3.60e-01 | 0.1524 |
65108 | MARCKSL1 | GSM4909297 | Human | Breast | IDC | 9.37e-33 | 2.52e-01 | 0.1517 |
65108 | MARCKSL1 | GSM4909298 | Human | Breast | IDC | 2.20e-38 | 6.06e-01 | 0.1551 |
65108 | MARCKSL1 | GSM4909301 | Human | Breast | IDC | 8.56e-03 | -3.07e-01 | 0.1577 |
65108 | MARCKSL1 | GSM4909304 | Human | Breast | IDC | 2.48e-04 | 3.19e-01 | 0.1636 |
65108 | MARCKSL1 | GSM4909305 | Human | Breast | IDC | 5.70e-14 | 4.60e-01 | 0.0436 |
65108 | MARCKSL1 | GSM4909306 | Human | Breast | IDC | 4.39e-40 | 6.50e-01 | 0.1564 |
65108 | MARCKSL1 | GSM4909307 | Human | Breast | IDC | 1.46e-10 | 3.26e-01 | 0.1569 |
65108 | MARCKSL1 | GSM4909308 | Human | Breast | IDC | 4.70e-14 | 4.28e-01 | 0.158 |
65108 | MARCKSL1 | GSM4909309 | Human | Breast | IDC | 1.74e-05 | 1.07e-01 | 0.0483 |
65108 | MARCKSL1 | GSM4909311 | Human | Breast | IDC | 1.71e-42 | -1.58e-01 | 0.1534 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701519 | Prostate | Tumor | actin filament organization | 142/3246 | 442/18723 | 1.40e-14 | 1.89e-12 | 142 |
GO:000701529 | Skin | cSCC | actin filament organization | 156/4864 | 442/18723 | 7.37e-06 | 1.02e-04 | 156 |
GO:00070156 | Stomach | GC | actin filament organization | 67/1159 | 442/18723 | 7.96e-12 | 2.20e-09 | 67 |
GO:000701511 | Stomach | CAG with IM | actin filament organization | 62/1050 | 442/18723 | 2.23e-11 | 4.96e-09 | 62 |
GO:000701521 | Stomach | CSG | actin filament organization | 62/1034 | 442/18723 | 1.18e-11 | 2.70e-09 | 62 |
GO:000701531 | Stomach | CAG | actin filament organization | 25/552 | 442/18723 | 1.52e-03 | 1.86e-02 | 25 |
GO:000701541 | Stomach | SIM | actin filament organization | 38/708 | 442/18723 | 2.29e-06 | 1.15e-04 | 38 |
GO:000701530 | Thyroid | HT | actin filament organization | 50/1272 | 442/18723 | 2.71e-04 | 3.73e-03 | 50 |
GO:0007015112 | Thyroid | PTC | actin filament organization | 225/5968 | 442/18723 | 3.76e-17 | 3.44e-15 | 225 |
GO:0007015210 | Thyroid | ATC | actin filament organization | 227/6293 | 442/18723 | 5.96e-15 | 3.85e-13 | 227 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0514012 | Breast | IDC | Leishmaniasis | 16/867 | 77/8465 | 4.35e-03 | 2.57e-02 | 1.92e-02 | 16 |
hsa0514013 | Breast | IDC | Leishmaniasis | 16/867 | 77/8465 | 4.35e-03 | 2.57e-02 | 1.92e-02 | 16 |
hsa0514021 | Breast | DCIS | Leishmaniasis | 17/846 | 77/8465 | 1.29e-03 | 9.06e-03 | 6.67e-03 | 17 |
hsa0514031 | Breast | DCIS | Leishmaniasis | 17/846 | 77/8465 | 1.29e-03 | 9.06e-03 | 6.67e-03 | 17 |
hsa04666 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa046661 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa046662 | Colorectum | SER | Fc gamma R-mediated phagocytosis | 39/1580 | 97/8465 | 5.84e-07 | 9.70e-06 | 7.04e-06 | 39 |
hsa046663 | Colorectum | SER | Fc gamma R-mediated phagocytosis | 39/1580 | 97/8465 | 5.84e-07 | 9.70e-06 | 7.04e-06 | 39 |
hsa046664 | Colorectum | MSS | Fc gamma R-mediated phagocytosis | 45/1875 | 97/8465 | 9.30e-08 | 1.56e-06 | 9.55e-07 | 45 |
hsa046665 | Colorectum | MSS | Fc gamma R-mediated phagocytosis | 45/1875 | 97/8465 | 9.30e-08 | 1.56e-06 | 9.55e-07 | 45 |
hsa046666 | Colorectum | FAP | Fc gamma R-mediated phagocytosis | 35/1404 | 97/8465 | 2.46e-06 | 4.28e-05 | 2.60e-05 | 35 |
hsa046667 | Colorectum | FAP | Fc gamma R-mediated phagocytosis | 35/1404 | 97/8465 | 2.46e-06 | 4.28e-05 | 2.60e-05 | 35 |
hsa0466614 | Endometrium | AEH | Fc gamma R-mediated phagocytosis | 27/1197 | 97/8465 | 3.02e-04 | 2.39e-03 | 1.75e-03 | 27 |
hsa0466615 | Endometrium | AEH | Fc gamma R-mediated phagocytosis | 27/1197 | 97/8465 | 3.02e-04 | 2.39e-03 | 1.75e-03 | 27 |
hsa0466621 | Endometrium | EEC | Fc gamma R-mediated phagocytosis | 27/1237 | 97/8465 | 5.15e-04 | 3.83e-03 | 2.85e-03 | 27 |
hsa0466631 | Endometrium | EEC | Fc gamma R-mediated phagocytosis | 27/1237 | 97/8465 | 5.15e-04 | 3.83e-03 | 2.85e-03 | 27 |
hsa0466620 | Esophagus | ESCC | Fc gamma R-mediated phagocytosis | 63/4205 | 97/8465 | 1.63e-03 | 4.89e-03 | 2.50e-03 | 63 |
hsa04666110 | Esophagus | ESCC | Fc gamma R-mediated phagocytosis | 63/4205 | 97/8465 | 1.63e-03 | 4.89e-03 | 2.50e-03 | 63 |
hsa0466610 | Liver | HCC | Fc gamma R-mediated phagocytosis | 58/4020 | 97/8465 | 9.65e-03 | 2.52e-02 | 1.40e-02 | 58 |
hsa0466611 | Liver | HCC | Fc gamma R-mediated phagocytosis | 58/4020 | 97/8465 | 9.65e-03 | 2.52e-02 | 1.40e-02 | 58 |
Page: 1 2 3 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MARCKSL1 | SNV | Missense_Mutation | c.356N>G | p.Ser119Cys | p.S119C | P49006 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MARCKSL1 | SNV | Missense_Mutation | c.480N>T | p.Glu160Asp | p.E160D | P49006 | protein_coding | tolerated(0.06) | probably_damaging(0.95) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MARCKSL1 | SNV | Missense_Mutation | c.310N>C | p.Ser104Pro | p.S104P | P49006 | protein_coding | tolerated(0.08) | possibly_damaging(0.518) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MARCKSL1 | SNV | Missense_Mutation | c.191C>T | p.Ala64Val | p.A64V | P49006 | protein_coding | deleterious(0.01) | benign(0.037) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD | |
MARCKSL1 | SNV | Missense_Mutation | c.320N>T | p.Arg107Ile | p.R107I | P49006 | protein_coding | deleterious(0) | possibly_damaging(0.701) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MARCKSL1 | SNV | Missense_Mutation | rs770620654 | c.276N>A | p.Phe92Leu | p.F92L | P49006 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MARCKSL1 | SNV | Missense_Mutation | rs770620654 | c.276C>A | p.Phe92Leu | p.F92L | P49006 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MARCKSL1 | SNV | Missense_Mutation | rs770620654 | c.276N>A | p.Phe92Leu | p.F92L | P49006 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
MARCKSL1 | SNV | Missense_Mutation | novel | c.565G>A | p.Ala189Thr | p.A189T | P49006 | protein_coding | tolerated(0.06) | benign(0.077) | TCGA-EY-A1GF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MARCKSL1 | insertion | Frame_Shift_Ins | rs749563695 | c.246dupC | p.Lys83GlnfsTer33 | p.K83Qfs*33 | P49006 | protein_coding | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
65108 | MARCKSL1 | KINASE | IFN | 11483670 | ||
65108 | MARCKSL1 | KINASE | IL-6 | 11483670 | ||
65108 | MARCKSL1 | KINASE | PMA | 8596017 | ||
65108 | MARCKSL1 | KINASE | TNF-ALPHA | 11483670 | ||
65108 | MARCKSL1 | KINASE | STAUROSPORINE | STAUROSPORINE | 1730592 | |
65108 | MARCKSL1 | KINASE | HERBIMYCIN A | 11483670 |
Page: 1 |