|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: MAPRE1 |
Gene summary for MAPRE1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MAPRE1 | Gene ID | 22919 |
| Gene name | microtubule associated protein RP/EB family member 1 | |
| Gene Alias | EB1 | |
| Cytomap | 20q11.21 | |
| Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q15691 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 22919 | MAPRE1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.12e-05 | 2.85e-01 | -0.0811 |
| 22919 | MAPRE1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.73e-02 | 2.19e-01 | -0.1088 |
| 22919 | MAPRE1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.66e-03 | 2.13e-01 | -0.1954 |
| 22919 | MAPRE1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.17e-04 | 2.74e-01 | -0.059 |
| 22919 | MAPRE1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.84e-06 | 2.44e-01 | 0.096 |
| 22919 | MAPRE1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.70e-10 | 4.35e-01 | 0.294 |
| 22919 | MAPRE1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.39e-11 | 5.86e-01 | 0.281 |
| 22919 | MAPRE1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.19e-26 | 7.39e-01 | 0.3859 |
| 22919 | MAPRE1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.16e-06 | 4.09e-01 | 0.2585 |
| 22919 | MAPRE1 | LZE4T | Human | Esophagus | ESCC | 6.05e-24 | 8.47e-01 | 0.0811 |
| 22919 | MAPRE1 | LZE7T | Human | Esophagus | ESCC | 3.32e-04 | 4.49e-01 | 0.0667 |
| 22919 | MAPRE1 | LZE8T | Human | Esophagus | ESCC | 3.02e-09 | 2.82e-01 | 0.067 |
| 22919 | MAPRE1 | LZE20T | Human | Esophagus | ESCC | 7.42e-06 | 1.15e-01 | 0.0662 |
| 22919 | MAPRE1 | LZE24T | Human | Esophagus | ESCC | 1.39e-28 | 1.21e+00 | 0.0596 |
| 22919 | MAPRE1 | LZE6T | Human | Esophagus | ESCC | 1.19e-05 | 4.41e-01 | 0.0845 |
| 22919 | MAPRE1 | P1T-E | Human | Esophagus | ESCC | 4.15e-02 | 4.90e-01 | 0.0875 |
| 22919 | MAPRE1 | P2T-E | Human | Esophagus | ESCC | 1.76e-38 | 8.53e-01 | 0.1177 |
| 22919 | MAPRE1 | P4T-E | Human | Esophagus | ESCC | 1.33e-28 | 7.06e-01 | 0.1323 |
| 22919 | MAPRE1 | P5T-E | Human | Esophagus | ESCC | 4.52e-34 | 7.45e-01 | 0.1327 |
| 22919 | MAPRE1 | P8T-E | Human | Esophagus | ESCC | 4.08e-26 | 7.36e-01 | 0.0889 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0051225 | Colorectum | AD | spindle assembly | 37/3918 | 117/18723 | 4.32e-03 | 2.96e-02 | 37 |
| GO:0070507 | Colorectum | AD | regulation of microtubule cytoskeleton organization | 44/3918 | 148/18723 | 7.05e-03 | 4.31e-02 | 44 |
| GO:19029032 | Colorectum | MSS | regulation of supramolecular fiber organization | 121/3467 | 383/18723 | 3.63e-10 | 3.28e-08 | 121 |
| GO:00322712 | Colorectum | MSS | regulation of protein polymerization | 83/3467 | 233/18723 | 3.99e-10 | 3.49e-08 | 83 |
| GO:00432542 | Colorectum | MSS | regulation of protein-containing complex assembly | 130/3467 | 428/18723 | 1.38e-09 | 1.03e-07 | 130 |
| GO:19029052 | Colorectum | MSS | positive regulation of supramolecular fiber organization | 75/3467 | 209/18723 | 1.89e-09 | 1.35e-07 | 75 |
| GO:00313342 | Colorectum | MSS | positive regulation of protein-containing complex assembly | 82/3467 | 237/18723 | 2.49e-09 | 1.75e-07 | 82 |
| GO:00512582 | Colorectum | MSS | protein polymerization | 97/3467 | 297/18723 | 2.98e-09 | 2.07e-07 | 97 |
| GO:00510982 | Colorectum | MSS | regulation of binding | 113/3467 | 363/18723 | 3.55e-09 | 2.41e-07 | 113 |
| GO:00322732 | Colorectum | MSS | positive regulation of protein polymerization | 55/3467 | 138/18723 | 3.84e-09 | 2.55e-07 | 55 |
| GO:00514952 | Colorectum | MSS | positive regulation of cytoskeleton organization | 78/3467 | 226/18723 | 6.86e-09 | 4.32e-07 | 78 |
| GO:00106392 | Colorectum | MSS | negative regulation of organelle organization | 102/3467 | 348/18723 | 5.36e-07 | 2.05e-05 | 102 |
| GO:00510992 | Colorectum | MSS | positive regulation of binding | 59/3467 | 173/18723 | 7.11e-07 | 2.53e-05 | 59 |
| GO:00433932 | Colorectum | MSS | regulation of protein binding | 62/3467 | 196/18723 | 6.44e-06 | 1.69e-04 | 62 |
| GO:00322722 | Colorectum | MSS | negative regulation of protein polymerization | 30/3467 | 80/18723 | 5.05e-05 | 9.09e-04 | 30 |
| GO:00715391 | Colorectum | MSS | protein localization to centrosome | 16/3467 | 33/18723 | 8.66e-05 | 1.40e-03 | 16 |
| GO:19055081 | Colorectum | MSS | protein localization to microtubule organizing center | 16/3467 | 35/18723 | 2.07e-04 | 2.89e-03 | 16 |
| GO:00313332 | Colorectum | MSS | negative regulation of protein-containing complex assembly | 43/3467 | 141/18723 | 3.84e-04 | 4.85e-03 | 43 |
| GO:00070511 | Colorectum | MSS | spindle organization | 53/3467 | 184/18723 | 4.23e-04 | 5.19e-03 | 53 |
| GO:19029042 | Colorectum | MSS | negative regulation of supramolecular fiber organization | 49/3467 | 167/18723 | 4.30e-04 | 5.23e-03 | 49 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MAPRE1 | SNV | Missense_Mutation | novel | c.556G>A | p.Val186Met | p.V186M | Q15691 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-A2-A3XW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamyicin | CR |
| MAPRE1 | SNV | Missense_Mutation | novel | c.776N>A | p.Gly259Glu | p.G259E | Q15691 | protein_coding | tolerated(0.59) | probably_damaging(0.994) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| MAPRE1 | SNV | Missense_Mutation | c.257G>A | p.Gly86Asp | p.G86D | Q15691 | protein_coding | deleterious(0.04) | benign(0.041) | TCGA-F4-6809-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| MAPRE1 | SNV | Missense_Mutation | c.93T>G | p.Asn31Lys | p.N31K | Q15691 | protein_coding | deleterious(0.02) | possibly_damaging(0.56) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| MAPRE1 | SNV | Missense_Mutation | rs770912318 | c.260T>C | p.Val87Ala | p.V87A | Q15691 | protein_coding | deleterious(0.01) | possibly_damaging(0.75) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
| MAPRE1 | SNV | Missense_Mutation | novel | c.365A>C | p.Lys122Thr | p.K122T | Q15691 | protein_coding | tolerated(0.08) | benign(0.119) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| MAPRE1 | SNV | Missense_Mutation | c.28N>A | p.Val10Met | p.V10M | Q15691 | protein_coding | tolerated(0.12) | possibly_damaging(0.756) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| MAPRE1 | SNV | Missense_Mutation | rs771324465 | c.604N>A | p.Val202Ile | p.V202I | Q15691 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| MAPRE1 | SNV | Missense_Mutation | novel | c.802T>C | p.Tyr268His | p.Y268H | Q15691 | protein_coding | deleterious(0.03) | possibly_damaging(0.543) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
| MAPRE1 | SNV | Missense_Mutation | novel | c.266A>C | p.Lys89Thr | p.K89T | Q15691 | protein_coding | deleterious(0.02) | probably_damaging(0.936) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
| Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |