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Gene: MAGOHB |
Gene summary for MAGOHB |
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Gene information | Species | Human | Gene symbol | MAGOHB | Gene ID | 55110 |
Gene name | mago homolog B, exon junction complex subunit | |
Gene Alias | MGN2 | |
Cytomap | 12p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000184 | UniProtAcc | F5H6P7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55110 | MAGOHB | LZE4T | Human | Esophagus | ESCC | 2.28e-13 | 3.73e-01 | 0.0811 |
55110 | MAGOHB | LZE7T | Human | Esophagus | ESCC | 1.15e-12 | 6.98e-01 | 0.0667 |
55110 | MAGOHB | LZE8T | Human | Esophagus | ESCC | 4.09e-09 | 4.66e-01 | 0.067 |
55110 | MAGOHB | LZE20T | Human | Esophagus | ESCC | 3.81e-08 | 3.42e-01 | 0.0662 |
55110 | MAGOHB | LZE22D1 | Human | Esophagus | HGIN | 1.35e-03 | 1.25e-01 | 0.0595 |
55110 | MAGOHB | LZE22T | Human | Esophagus | ESCC | 2.26e-07 | 4.39e-01 | 0.068 |
55110 | MAGOHB | LZE24T | Human | Esophagus | ESCC | 6.55e-14 | 3.21e-01 | 0.0596 |
55110 | MAGOHB | LZE6T | Human | Esophagus | ESCC | 7.78e-10 | 3.75e-01 | 0.0845 |
55110 | MAGOHB | P1T-E | Human | Esophagus | ESCC | 3.26e-05 | 2.37e-01 | 0.0875 |
55110 | MAGOHB | P2T-E | Human | Esophagus | ESCC | 2.75e-30 | 6.83e-01 | 0.1177 |
55110 | MAGOHB | P4T-E | Human | Esophagus | ESCC | 2.97e-54 | 1.20e+00 | 0.1323 |
55110 | MAGOHB | P5T-E | Human | Esophagus | ESCC | 1.80e-33 | 6.83e-01 | 0.1327 |
55110 | MAGOHB | P8T-E | Human | Esophagus | ESCC | 2.80e-25 | 4.71e-01 | 0.0889 |
55110 | MAGOHB | P9T-E | Human | Esophagus | ESCC | 5.16e-23 | 4.66e-01 | 0.1131 |
55110 | MAGOHB | P10T-E | Human | Esophagus | ESCC | 7.18e-36 | 5.95e-01 | 0.116 |
55110 | MAGOHB | P11T-E | Human | Esophagus | ESCC | 6.39e-15 | 3.26e-01 | 0.1426 |
55110 | MAGOHB | P12T-E | Human | Esophagus | ESCC | 1.04e-50 | 1.01e+00 | 0.1122 |
55110 | MAGOHB | P15T-E | Human | Esophagus | ESCC | 3.56e-21 | 3.82e-01 | 0.1149 |
55110 | MAGOHB | P16T-E | Human | Esophagus | ESCC | 8.59e-77 | 1.78e+00 | 0.1153 |
55110 | MAGOHB | P17T-E | Human | Esophagus | ESCC | 9.89e-15 | 4.97e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:0006401110 | Esophagus | ESCC | RNA catabolic process | 204/8552 | 278/18723 | 3.39e-21 | 5.66e-19 | 204 |
GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
GO:005102815 | Esophagus | ESCC | mRNA transport | 110/8552 | 130/18723 | 2.76e-20 | 3.80e-18 | 110 |
GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:0034655110 | Esophagus | ESCC | nucleobase-containing compound catabolic process | 272/8552 | 407/18723 | 2.92e-18 | 2.90e-16 | 272 |
GO:0006402110 | Esophagus | ESCC | mRNA catabolic process | 170/8552 | 232/18723 | 8.70e-18 | 8.00e-16 | 170 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:004670018 | Esophagus | ESCC | heterocycle catabolic process | 286/8552 | 445/18723 | 1.12e-15 | 7.47e-14 | 286 |
GO:004427019 | Esophagus | ESCC | cellular nitrogen compound catabolic process | 288/8552 | 451/18723 | 3.03e-15 | 1.79e-13 | 288 |
GO:001943918 | Esophagus | ESCC | aromatic compound catabolic process | 295/8552 | 467/18723 | 1.09e-14 | 5.98e-13 | 295 |
GO:190136118 | Esophagus | ESCC | organic cyclic compound catabolic process | 307/8552 | 495/18723 | 9.99e-14 | 4.80e-12 | 307 |
GO:000095618 | Esophagus | ESCC | nuclear-transcribed mRNA catabolic process | 88/8552 | 112/18723 | 9.41e-13 | 4.14e-11 | 88 |
GO:000018414 | Esophagus | ESCC | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 32/8552 | 37/18723 | 2.96e-07 | 4.23e-06 | 32 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:000037512 | Liver | Cirrhotic | RNA splicing, via transesterification reactions | 175/4634 | 324/18723 | 5.95e-30 | 7.47e-27 | 175 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa030159 | Esophagus | HGIN | mRNA surveillance pathway | 30/1383 | 97/8465 | 2.48e-04 | 2.69e-03 | 2.14e-03 | 30 |
hsa030137 | Esophagus | HGIN | Nucleocytoplasmic transport | 31/1383 | 108/8465 | 8.29e-04 | 7.95e-03 | 6.31e-03 | 31 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0301514 | Esophagus | HGIN | mRNA surveillance pathway | 30/1383 | 97/8465 | 2.48e-04 | 2.69e-03 | 2.14e-03 | 30 |
hsa0301312 | Esophagus | HGIN | Nucleocytoplasmic transport | 31/1383 | 108/8465 | 8.29e-04 | 7.95e-03 | 6.31e-03 | 31 |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0301524 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0301534 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa030154 | Liver | Cirrhotic | mRNA surveillance pathway | 46/2530 | 97/8465 | 1.92e-04 | 1.30e-03 | 8.03e-04 | 46 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0301511 | Liver | Cirrhotic | mRNA surveillance pathway | 46/2530 | 97/8465 | 1.92e-04 | 1.30e-03 | 8.03e-04 | 46 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0301521 | Liver | HCC | mRNA surveillance pathway | 66/4020 | 97/8465 | 3.16e-05 | 1.88e-04 | 1.04e-04 | 66 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAGOHB | SNV | Missense_Mutation | c.323N>A | p.Ser108Tyr | p.S108Y | Q96A72 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAGOHB | SNV | Missense_Mutation | rs754343052 | c.226N>A | p.Asp76Asn | p.D76N | Q96A72 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MAGOHB | SNV | Missense_Mutation | novel | c.254T>G | p.Val85Gly | p.V85G | Q96A72 | protein_coding | tolerated(0.22) | benign(0.444) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MAGOHB | SNV | Missense_Mutation | c.365N>A | p.Arg122Gln | p.R122Q | Q96A72 | protein_coding | tolerated(0.19) | benign(0.065) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MAGOHB | SNV | Missense_Mutation | c.335N>C | p.Val112Ala | p.V112A | Q96A72 | protein_coding | deleterious(0.02) | possibly_damaging(0.665) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAGOHB | SNV | Missense_Mutation | rs745448693 | c.10G>A | p.Ala4Thr | p.A4T | Q96A72 | protein_coding | tolerated(0.26) | benign(0) | TCGA-EC-A24G-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
MAGOHB | SNV | Missense_Mutation | c.323C>A | p.Ser108Tyr | p.S108Y | Q96A72 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MAGOHB | SNV | Missense_Mutation | novel | c.95N>T | p.Gly32Val | p.G32V | Q96A72 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MAGOHB | SNV | Missense_Mutation | novel | c.41N>T | p.Gly14Val | p.G14V | Q96A72 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-78-7539-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
MAGOHB | SNV | Missense_Mutation | c.260N>A | p.Arg87Gln | p.R87Q | Q96A72 | protein_coding | tolerated(0.06) | benign(0.049) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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