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Gene: MAFG |
Gene summary for MAFG |
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Gene information | Species | Human | Gene symbol | MAFG | Gene ID | 4097 |
Gene name | MAF bZIP transcription factor G | |
Gene Alias | hMAF | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | A0A024R8X1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4097 | MAFG | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.02e-07 | 2.13e-01 | 0.0155 |
4097 | MAFG | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.60e-07 | 4.70e-01 | -0.1808 |
4097 | MAFG | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.96e-08 | 5.24e-01 | -0.0811 |
4097 | MAFG | HTA11_78_2000001011 | Human | Colorectum | AD | 7.84e-04 | 2.69e-01 | -0.1088 |
4097 | MAFG | HTA11_347_2000001011 | Human | Colorectum | AD | 1.19e-07 | 3.04e-01 | -0.1954 |
4097 | MAFG | HTA11_411_2000001011 | Human | Colorectum | SER | 1.69e-03 | 7.44e-01 | -0.2602 |
4097 | MAFG | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.63e-02 | 2.93e-01 | -0.1207 |
4097 | MAFG | HTA11_83_2000001011 | Human | Colorectum | SER | 1.66e-10 | 5.60e-01 | -0.1526 |
4097 | MAFG | HTA11_696_2000001011 | Human | Colorectum | AD | 2.78e-12 | 4.08e-01 | -0.1464 |
4097 | MAFG | HTA11_866_2000001011 | Human | Colorectum | AD | 1.29e-04 | 1.95e-01 | -0.1001 |
4097 | MAFG | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.52e-10 | 4.32e-01 | -0.059 |
4097 | MAFG | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.08e-02 | 3.46e-01 | -0.2061 |
4097 | MAFG | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.60e-02 | 2.82e-01 | -0.0179 |
4097 | MAFG | HTA11_866_3004761011 | Human | Colorectum | AD | 1.18e-10 | 3.92e-01 | 0.096 |
4097 | MAFG | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.26e-03 | 3.46e-01 | 0.0528 |
4097 | MAFG | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.08e-06 | 2.36e-01 | 0.0674 |
4097 | MAFG | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.26e-03 | 3.85e-01 | 0.0112 |
4097 | MAFG | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.17e-03 | 3.31e-01 | 0.0588 |
4097 | MAFG | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.22e-20 | 5.86e-01 | 0.294 |
4097 | MAFG | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.06e-04 | 7.92e-01 | 0.3487 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00085447 | Endometrium | AEH | epidermis development | 52/2100 | 324/18723 | 5.00e-03 | 3.14e-02 | 52 |
GO:000170114 | Endometrium | EEC | in utero embryonic development | 75/2168 | 367/18723 | 5.86e-07 | 2.16e-05 | 75 |
GO:003085613 | Endometrium | EEC | regulation of epithelial cell differentiation | 34/2168 | 154/18723 | 1.47e-04 | 1.87e-03 | 34 |
GO:004568212 | Endometrium | EEC | regulation of epidermis development | 16/2168 | 65/18723 | 2.51e-03 | 1.83e-02 | 16 |
GO:004560412 | Endometrium | EEC | regulation of epidermal cell differentiation | 14/2168 | 58/18723 | 5.49e-03 | 3.33e-02 | 14 |
GO:000854414 | Endometrium | EEC | epidermis development | 53/2168 | 324/18723 | 5.92e-03 | 3.54e-02 | 53 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
GO:000991310 | Esophagus | ESCC | epidermal cell differentiation | 122/8552 | 202/18723 | 1.69e-05 | 1.51e-04 | 122 |
GO:00456826 | Esophagus | ESCC | regulation of epidermis development | 46/8552 | 65/18723 | 3.65e-05 | 2.97e-04 | 46 |
GO:00456046 | Esophagus | ESCC | regulation of epidermal cell differentiation | 41/8552 | 58/18723 | 1.00e-04 | 7.10e-04 | 41 |
GO:00017015 | Liver | Cirrhotic | in utero embryonic development | 134/4634 | 367/18723 | 2.78e-07 | 6.86e-06 | 134 |
GO:00300045 | Liver | Cirrhotic | cellular monovalent inorganic cation homeostasis | 38/4634 | 103/18723 | 4.02e-03 | 2.17e-02 | 38 |
GO:00306415 | Liver | Cirrhotic | regulation of cellular pH | 31/4634 | 81/18723 | 4.76e-03 | 2.50e-02 | 31 |
GO:00068853 | Liver | Cirrhotic | regulation of pH | 33/4634 | 91/18723 | 9.39e-03 | 4.29e-02 | 33 |
GO:000170111 | Liver | HCC | in utero embryonic development | 204/7958 | 367/18723 | 2.44e-07 | 4.30e-06 | 204 |
GO:000170116 | Oral cavity | OSCC | in utero embryonic development | 207/7305 | 367/18723 | 7.92e-12 | 2.95e-10 | 207 |
GO:00085449 | Oral cavity | OSCC | epidermis development | 171/7305 | 324/18723 | 2.89e-07 | 4.43e-06 | 171 |
GO:00099139 | Oral cavity | OSCC | epidermal cell differentiation | 109/7305 | 202/18723 | 1.08e-05 | 1.14e-04 | 109 |
GO:00456825 | Oral cavity | OSCC | regulation of epidermis development | 41/7305 | 65/18723 | 7.29e-05 | 5.73e-04 | 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAFG | SNV | Missense_Mutation | novel | c.356N>A | p.Arg119Gln | p.R119Q | O15525 | protein_coding | deleterious(0.02) | benign(0.358) | TCGA-AX-A1C4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAFG | SNV | Missense_Mutation | c.170G>A | p.Arg57His | p.R57H | O15525 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAFG | SNV | Missense_Mutation | rs772676495 | c.81N>C | p.Glu27Asp | p.E27D | O15525 | protein_coding | tolerated(1) | benign(0.003) | TCGA-55-1595-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAFG | SNV | Missense_Mutation | novel | c.44N>A | p.Arg15Gln | p.R15Q | O15525 | protein_coding | tolerated(0.13) | benign(0.081) | TCGA-MP-A4SW-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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