Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/LSG1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/LSG1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/LSG1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/LSG1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003150314 | Esophagus | ESCC | protein-containing complex localization | 139/8552 | 220/18723 | 1.14e-07 | 1.85e-06 | 139 |
GO:000005411 | Esophagus | ESCC | ribosomal subunit export from nucleus | 13/8552 | 14/18723 | 3.02e-04 | 1.81e-03 | 13 |
GO:003375011 | Esophagus | ESCC | ribosome localization | 13/8552 | 14/18723 | 3.02e-04 | 1.81e-03 | 13 |
GO:007142811 | Esophagus | ESCC | rRNA-containing ribonucleoprotein complex export from nucleus | 13/8552 | 15/18723 | 1.31e-03 | 6.26e-03 | 13 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:000691322 | Liver | HCC | nucleocytoplasmic transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
GO:005116922 | Liver | HCC | nuclear transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
GO:005116822 | Liver | HCC | nuclear export | 113/7958 | 154/18723 | 6.30e-15 | 4.39e-13 | 113 |
GO:005165621 | Liver | HCC | establishment of organelle localization | 226/7958 | 390/18723 | 4.15e-10 | 1.34e-08 | 226 |
GO:00711661 | Liver | HCC | ribonucleoprotein complex localization | 59/7958 | 77/18723 | 1.09e-09 | 3.30e-08 | 59 |
GO:00714261 | Liver | HCC | ribonucleoprotein complex export from nucleus | 58/7958 | 76/18723 | 1.98e-09 | 5.63e-08 | 58 |
GO:00315031 | Liver | HCC | protein-containing complex localization | 129/7958 | 220/18723 | 9.38e-07 | 1.42e-05 | 129 |
GO:00000544 | Liver | HCC | ribosomal subunit export from nucleus | 12/7958 | 14/18723 | 1.17e-03 | 6.54e-03 | 12 |
GO:00337504 | Liver | HCC | ribosome localization | 12/7958 | 14/18723 | 1.17e-03 | 6.54e-03 | 12 |
GO:00714282 | Liver | HCC | rRNA-containing ribonucleoprotein complex export from nucleus | 12/7958 | 15/18723 | 3.56e-03 | 1.59e-02 | 12 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:000691317 | Oral cavity | OSCC | nucleocytoplasmic transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:005116917 | Oral cavity | OSCC | nuclear transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LSG1 | SNV | Missense_Mutation | rs547942305 | c.476G>A | p.Arg159Gln | p.R159Q | Q9H089 | protein_coding | deleterious(0.01) | probably_damaging(0.923) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
LSG1 | SNV | Missense_Mutation | | c.1102N>C | p.Glu368Gln | p.E368Q | Q9H089 | protein_coding | tolerated(0.1) | possibly_damaging(0.562) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
LSG1 | SNV | Missense_Mutation | | c.1579N>A | p.Asp527Asn | p.D527N | Q9H089 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A1AO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
LSG1 | SNV | Missense_Mutation | rs147988904 | c.665G>A | p.Arg222Gln | p.R222Q | Q9H089 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B6-A0I6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
LSG1 | insertion | Nonsense_Mutation | novel | c.262_263insTTGACTCCATTTGAACGAAATTTGGACTTTTGGC | p.Arg88IlefsTer5 | p.R88Ifs*5 | Q9H089 | protein_coding | | | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
LSG1 | deletion | In_Frame_Del | | c.456_458delNNN | p.Ile153del | p.I153del | Q9H089 | protein_coding | | | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LSG1 | SNV | Missense_Mutation | novel | c.1691G>A | p.Arg564Gln | p.R564Q | Q9H089 | protein_coding | tolerated(0.34) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LSG1 | SNV | Missense_Mutation | novel | c.1223G>A | p.Gly408Asp | p.G408D | Q9H089 | protein_coding | tolerated(0.6) | possibly_damaging(0.864) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LSG1 | SNV | Missense_Mutation | novel | c.927C>A | p.Asp309Glu | p.D309E | Q9H089 | protein_coding | tolerated(0.21) | benign(0.025) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LSG1 | SNV | Missense_Mutation | novel | c.1066N>A | p.Gln356Lys | p.Q356K | Q9H089 | protein_coding | tolerated(0.93) | benign(0.001) | TCGA-C5-A902-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |