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Gene: LRRC59 |
Gene summary for LRRC59 |
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Gene information | Species | Human | Gene symbol | LRRC59 | Gene ID | 55379 |
Gene name | leucine rich repeat containing 59 | |
Gene Alias | PRO1855 | |
Cytomap | 17q21.33 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q96AG4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55379 | LRRC59 | GSM4909282 | Human | Breast | IDC | 1.11e-16 | -2.98e-01 | -0.0288 |
55379 | LRRC59 | GSM4909290 | Human | Breast | IDC | 5.08e-05 | 3.72e-01 | 0.2096 |
55379 | LRRC59 | GSM4909291 | Human | Breast | IDC | 8.06e-41 | 9.53e-01 | 0.1753 |
55379 | LRRC59 | GSM4909294 | Human | Breast | IDC | 2.09e-02 | -1.88e-01 | 0.2022 |
55379 | LRRC59 | GSM4909296 | Human | Breast | IDC | 4.89e-10 | -2.35e-01 | 0.1524 |
55379 | LRRC59 | GSM4909297 | Human | Breast | IDC | 3.91e-08 | -1.72e-01 | 0.1517 |
55379 | LRRC59 | GSM4909301 | Human | Breast | IDC | 3.33e-02 | -1.75e-01 | 0.1577 |
55379 | LRRC59 | GSM4909311 | Human | Breast | IDC | 3.27e-17 | -2.08e-01 | 0.1534 |
55379 | LRRC59 | GSM4909312 | Human | Breast | IDC | 1.68e-05 | 1.14e-02 | 0.1552 |
55379 | LRRC59 | GSM4909319 | Human | Breast | IDC | 4.90e-23 | -2.03e-01 | 0.1563 |
55379 | LRRC59 | GSM4909320 | Human | Breast | IDC | 2.12e-02 | -1.82e-01 | 0.1575 |
55379 | LRRC59 | GSM4909321 | Human | Breast | IDC | 5.81e-09 | -1.74e-01 | 0.1559 |
55379 | LRRC59 | brca1 | Human | Breast | Precancer | 3.54e-18 | 5.81e-01 | -0.0338 |
55379 | LRRC59 | brca2 | Human | Breast | Precancer | 2.04e-08 | 3.58e-01 | -0.024 |
55379 | LRRC59 | brca3 | Human | Breast | Precancer | 4.89e-07 | 2.89e-01 | -0.0263 |
55379 | LRRC59 | M2 | Human | Breast | IDC | 3.65e-03 | 2.56e-01 | 0.21 |
55379 | LRRC59 | NCCBC14 | Human | Breast | DCIS | 6.27e-04 | 1.61e-01 | 0.2021 |
55379 | LRRC59 | NCCBC3 | Human | Breast | DCIS | 1.66e-02 | -8.19e-02 | 0.1198 |
55379 | LRRC59 | P1 | Human | Breast | IDC | 9.22e-11 | 5.19e-02 | 0.1527 |
55379 | LRRC59 | P2 | Human | Breast | IDC | 4.79e-16 | 6.68e-01 | 0.21 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000726524 | Thyroid | ATC | Ras protein signal transduction | 172/6293 | 337/18723 | 2.25e-11 | 7.96e-10 | 172 |
GO:005105618 | Thyroid | ATC | regulation of small GTPase mediated signal transduction | 141/6293 | 302/18723 | 1.43e-06 | 1.77e-05 | 141 |
GO:004657818 | Thyroid | ATC | regulation of Ras protein signal transduction | 94/6293 | 189/18723 | 3.12e-06 | 3.55e-05 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRC59 | SNV | Missense_Mutation | c.402N>C | p.Glu134Asp | p.E134D | Q96AG4 | protein_coding | tolerated(0.16) | benign(0.133) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
LRRC59 | insertion | Frame_Shift_Ins | novel | c.380_381insT | p.Ala128GlyfsTer3 | p.A128Gfs*3 | Q96AG4 | protein_coding | TCGA-A2-A0EU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LRRC59 | insertion | In_Frame_Ins | novel | c.378_379insCAGCATGCAAGACAACTATTGTCTGTG | p.Lys126_Val127insGlnHisAlaArgGlnLeuLeuSerVal | p.K126_V127insQHARQLLSV | Q96AG4 | protein_coding | TCGA-A2-A0EU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LRRC59 | SNV | Missense_Mutation | rs139115894 | c.482N>A | p.Arg161Gln | p.R161Q | Q96AG4 | protein_coding | tolerated(0.18) | benign(0.03) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LRRC59 | SNV | Missense_Mutation | novel | c.361N>C | p.Asp121His | p.D121H | Q96AG4 | protein_coding | deleterious(0) | possibly_damaging(0.79) | TCGA-C5-A1MP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LRRC59 | insertion | In_Frame_Ins | novel | c.437_438insCCTGCAATCCCA | p.Leu145_Gln146insHisLeuGlnSer | p.L145_Q146insHLQS | Q96AG4 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
LRRC59 | SNV | Missense_Mutation | c.443N>C | p.Met148Thr | p.M148T | Q96AG4 | protein_coding | deleterious(0) | possibly_damaging(0.637) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LRRC59 | SNV | Missense_Mutation | rs200977500 | c.451G>A | p.Val151Met | p.V151M | Q96AG4 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
LRRC59 | SNV | Missense_Mutation | rs143077743 | c.481N>T | p.Arg161Trp | p.R161W | Q96AG4 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LRRC59 | SNV | Missense_Mutation | c.629N>G | p.Lys210Arg | p.K210R | Q96AG4 | protein_coding | tolerated(0.21) | possibly_damaging(0.531) | TCGA-AF-2693-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55379 | LRRC59 | NA | MELAGATRAN | MELAGATRAN | 22494098 |
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