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Gene: LEPROT |
Gene summary for LEPROT |
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Gene information | Species | Human | Gene symbol | LEPROT | Gene ID | 54741 |
Gene name | leptin receptor overlapping transcript | |
Gene Alias | LEPR | |
Cytomap | 1p31.3 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | A0A087X0N2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54741 | LEPROT | CA_HPV_1 | Human | Cervix | CC | 4.34e-08 | -2.96e-01 | 0.0264 |
54741 | LEPROT | CCI_1 | Human | Cervix | CC | 1.11e-08 | -5.13e-01 | 0.528 |
54741 | LEPROT | CCI_2 | Human | Cervix | CC | 6.44e-08 | -5.13e-01 | 0.5249 |
54741 | LEPROT | CCI_3 | Human | Cervix | CC | 9.21e-12 | -5.13e-01 | 0.516 |
54741 | LEPROT | CCII_1 | Human | Cervix | CC | 1.79e-16 | -5.13e-01 | 0.3249 |
54741 | LEPROT | sample1 | Human | Cervix | CC | 2.49e-02 | -3.05e-01 | 0.0959 |
54741 | LEPROT | T1 | Human | Cervix | CC | 1.78e-09 | -3.71e-01 | 0.0918 |
54741 | LEPROT | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.92e-09 | 1.93e-01 | 0.0155 |
54741 | LEPROT | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.16e-13 | 3.64e-01 | -0.1808 |
54741 | LEPROT | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.05e-20 | 5.36e-01 | -0.0811 |
54741 | LEPROT | HTA11_78_2000001011 | Human | Colorectum | AD | 1.18e-19 | 5.27e-01 | -0.1088 |
54741 | LEPROT | HTA11_347_2000001011 | Human | Colorectum | AD | 1.72e-42 | 7.70e-01 | -0.1954 |
54741 | LEPROT | HTA11_411_2000001011 | Human | Colorectum | SER | 4.42e-10 | 6.00e-01 | -0.2602 |
54741 | LEPROT | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.50e-04 | 3.07e-01 | -0.2196 |
54741 | LEPROT | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.49e-10 | 3.60e-01 | -0.1207 |
54741 | LEPROT | HTA11_83_2000001011 | Human | Colorectum | SER | 7.80e-11 | 3.71e-01 | -0.1526 |
54741 | LEPROT | HTA11_696_2000001011 | Human | Colorectum | AD | 1.44e-19 | 3.65e-01 | -0.1464 |
54741 | LEPROT | HTA11_866_2000001011 | Human | Colorectum | AD | 1.73e-12 | 2.55e-01 | -0.1001 |
54741 | LEPROT | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.12e-18 | 4.47e-01 | -0.059 |
54741 | LEPROT | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.51e-04 | 2.87e-01 | -0.1706 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19037494 | Cervix | CC | positive regulation of establishment of protein localization to mitochondrion | 11/2311 | 36/18723 | 3.11e-03 | 2.04e-02 | 11 |
GO:19035334 | Cervix | CC | regulation of protein targeting | 19/2311 | 81/18723 | 3.96e-03 | 2.48e-02 | 19 |
GO:19039553 | Cervix | CC | positive regulation of protein targeting to mitochondrion | 10/2311 | 32/18723 | 3.96e-03 | 2.48e-02 | 10 |
GO:19038286 | Cervix | CC | negative regulation of cellular protein localization | 24/2311 | 117/18723 | 8.10e-03 | 4.23e-02 | 24 |
GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:0090316 | Colorectum | AD | positive regulation of intracellular protein transport | 62/3918 | 160/18723 | 1.82e-07 | 7.79e-06 | 62 |
GO:0032388 | Colorectum | AD | positive regulation of intracellular transport | 74/3918 | 202/18723 | 1.83e-07 | 7.80e-06 | 74 |
GO:0070585 | Colorectum | AD | protein localization to mitochondrion | 51/3918 | 125/18723 | 3.40e-07 | 1.33e-05 | 51 |
GO:0007034 | Colorectum | AD | vacuolar transport | 60/3918 | 157/18723 | 4.97e-07 | 1.85e-05 | 60 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0033157 | Colorectum | AD | regulation of intracellular protein transport | 80/3918 | 229/18723 | 5.81e-07 | 2.09e-05 | 80 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LEPROT | deletion | Frame_Shift_Del | novel | c.165delC | p.Ile56SerfsTer47 | p.I56Sfs*47 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
LEPROT | deletion | Frame_Shift_Del | novel | c.87delT | p.Met31CysfsTer6 | p.M31Cfs*6 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
LEPROT | SNV | Missense_Mutation | novel | c.373N>G | p.Phe125Val | p.F125V | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LEPROT | insertion | Frame_Shift_Ins | novel | c.70dupG | p.Ala24GlyfsTer44 | p.A24Gfs*44 | protein_coding | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
LEPROT | SNV | Missense_Mutation | c.254N>A | p.Gly85Glu | p.G85E | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
LEPROT | SNV | Missense_Mutation | novel | c.346N>A | p.Ala116Thr | p.A116T | protein_coding | tolerated(0.56) | benign(0.031) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LEPROT | SNV | Missense_Mutation | novel | c.373N>C | p.Phe125Leu | p.F125L | protein_coding | deleterious(0.02) | probably_damaging(0.928) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
LEPROT | SNV | Missense_Mutation | novel | c.358N>A | p.Leu120Ile | p.L120I | protein_coding | tolerated(0.37) | benign(0.073) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD | |
LEPROT | SNV | Missense_Mutation | novel | c.151N>T | p.His51Tyr | p.H51Y | protein_coding | tolerated(1) | benign(0) | TCGA-86-7954-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
LEPROT | SNV | Missense_Mutation | novel | c.121G>T | p.Val41Phe | p.V41F | protein_coding | deleterious(0.05) | possibly_damaging(0.881) | TCGA-97-7941-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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