GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00182052 | Liver | HCC | peptidyl-lysine modification | 230/7958 | 376/18723 | 1.51e-13 | 8.32e-12 | 230 |
GO:003052222 | Liver | HCC | intracellular receptor signaling pathway | 171/7958 | 265/18723 | 3.00e-13 | 1.61e-11 | 171 |
GO:004854522 | Liver | HCC | response to steroid hormone | 206/7958 | 339/18723 | 6.81e-12 | 2.92e-10 | 206 |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:007138322 | Liver | HCC | cellular response to steroid hormone stimulus | 128/7958 | 204/18723 | 3.92e-09 | 1.04e-07 | 128 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:00064792 | Liver | HCC | protein methylation | 111/7958 | 181/18723 | 2.36e-07 | 4.18e-06 | 111 |
GO:00082132 | Liver | HCC | protein alkylation | 111/7958 | 181/18723 | 2.36e-07 | 4.18e-06 | 111 |
GO:00165712 | Liver | HCC | histone methylation | 88/7958 | 141/18723 | 1.41e-06 | 2.02e-05 | 88 |
GO:004340121 | Liver | HCC | steroid hormone mediated signaling pathway | 84/7958 | 136/18723 | 4.42e-06 | 5.62e-05 | 84 |
GO:003051821 | Liver | HCC | intracellular steroid hormone receptor signaling pathway | 73/7958 | 116/18723 | 7.04e-06 | 8.41e-05 | 73 |
GO:003314321 | Liver | HCC | regulation of intracellular steroid hormone receptor signaling pathway | 49/7958 | 74/18723 | 3.21e-05 | 3.26e-04 | 49 |
GO:00349681 | Liver | HCC | histone lysine methylation | 70/7958 | 115/18723 | 5.32e-05 | 5.04e-04 | 70 |
GO:0033146 | Liver | HCC | regulation of intracellular estrogen receptor signaling pathway | 26/7958 | 35/18723 | 1.37e-04 | 1.11e-03 | 26 |
GO:000975521 | Liver | HCC | hormone-mediated signaling pathway | 106/7958 | 190/18723 | 1.45e-04 | 1.17e-03 | 106 |
GO:003052021 | Liver | HCC | intracellular estrogen receptor signaling pathway | 35/7958 | 54/18723 | 7.73e-04 | 4.65e-03 | 35 |
GO:00180221 | Liver | HCC | peptidyl-lysine methylation | 74/7958 | 131/18723 | 8.46e-04 | 5.06e-03 | 74 |
GO:0033148 | Liver | HCC | positive regulation of intracellular estrogen receptor signaling pathway | 10/7958 | 11/18723 | 1.30e-03 | 7.01e-03 | 10 |
GO:0033145 | Liver | HCC | positive regulation of intracellular steroid hormone receptor signaling pathway | 11/7958 | 13/18723 | 2.38e-03 | 1.16e-02 | 11 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KMT2D | SNV | Missense_Mutation | novel | c.5042C>A | p.Thr1681Asn | p.T1681N | O14686 | protein_coding | deleterious(0) | possibly_damaging(0.852) | TCGA-3C-AALJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
KMT2D | SNV | Missense_Mutation | novel | c.10413G>C | p.Gln3471His | p.Q3471H | O14686 | protein_coding | deleterious(0.01) | possibly_damaging(0.804) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
KMT2D | SNV | Missense_Mutation | | c.10760N>T | p.Glu3587Val | p.E3587V | O14686 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
KMT2D | SNV | Missense_Mutation | | c.3061N>T | p.Pro1021Ser | p.P1021S | O14686 | protein_coding | deleterious_low_confidence(0.04) | benign(0.003) | TCGA-A2-A25B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | PD |
KMT2D | SNV | Missense_Mutation | | c.10744C>T | p.Arg3582Trp | p.R3582W | O14686 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A076-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
KMT2D | SNV | Missense_Mutation | novel | c.6007C>G | p.Leu2003Val | p.L2003V | O14686 | protein_coding | deleterious(0.02) | probably_damaging(0.939) | TCGA-AC-A7VC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KMT2D | SNV | Missense_Mutation | | c.13410N>T | p.Lys4470Asn | p.K4470N | O14686 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KMT2D | SNV | Missense_Mutation | rs766696812 | c.10876N>T | p.Arg3626Trp | p.R3626W | O14686 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KMT2D | SNV | Missense_Mutation | rs775632051 | c.10640G>A | p.Arg3547His | p.R3547H | O14686 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KMT2D | SNV | Missense_Mutation | novel | c.12089N>C | p.Asp4030Ala | p.D4030A | O14686 | protein_coding | deleterious_low_confidence(0.02) | benign(0) | TCGA-AR-A1AP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |