Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/KIFC3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/KIFC3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/KIFC3_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/KIFC3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/KIFC3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/KIFC3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004395421 | Lung | MIAC | cellular component maintenance | 10/967 | 61/18723 | 1.05e-03 | 2.12e-02 | 10 |
GO:000703021 | Lung | MIAC | Golgi organization | 18/967 | 157/18723 | 1.27e-03 | 2.37e-02 | 18 |
GO:003433122 | Lung | MIAC | cell junction maintenance | 7/967 | 35/18723 | 1.81e-03 | 2.95e-02 | 7 |
GO:003433212 | Lung | MIAC | adherens junction organization | 8/967 | 49/18723 | 3.36e-03 | 4.37e-02 | 8 |
GO:00070307 | Oral cavity | OSCC | Golgi organization | 92/7305 | 157/18723 | 4.96e-07 | 7.27e-06 | 92 |
GO:004521618 | Oral cavity | OSCC | cell-cell junction organization | 97/7305 | 200/18723 | 3.83e-03 | 1.57e-02 | 97 |
GO:00070309 | Skin | cSCC | Golgi organization | 64/4864 | 157/18723 | 3.53e-05 | 3.83e-04 | 64 |
GO:004521627 | Skin | cSCC | cell-cell junction organization | 69/4864 | 200/18723 | 4.46e-03 | 2.29e-02 | 69 |
GO:000703010 | Thyroid | PTC | Golgi organization | 79/5968 | 157/18723 | 1.11e-06 | 1.64e-05 | 79 |
GO:0045216111 | Thyroid | PTC | cell-cell junction organization | 93/5968 | 200/18723 | 1.01e-05 | 1.12e-04 | 93 |
GO:003433216 | Thyroid | PTC | adherens junction organization | 25/5968 | 49/18723 | 4.09e-03 | 1.95e-02 | 25 |
GO:004521629 | Thyroid | ATC | cell-cell junction organization | 99/6293 | 200/18723 | 2.26e-06 | 2.68e-05 | 99 |
GO:000703015 | Thyroid | ATC | Golgi organization | 79/6293 | 157/18723 | 1.07e-05 | 1.05e-04 | 79 |
GO:003433221 | Thyroid | ATC | adherens junction organization | 26/6293 | 49/18723 | 3.87e-03 | 1.68e-02 | 26 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIFC3 | SNV | Missense_Mutation | novel | c.676N>C | p.Glu226Gln | p.E226Q | Q9BVG8 | protein_coding | tolerated(0.22) | benign(0.186) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
KIFC3 | SNV | Missense_Mutation | | c.2389C>T | p.Arg797Cys | p.R797C | Q9BVG8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIFC3 | SNV | Missense_Mutation | novel | c.896N>A | p.Ala299Asp | p.A299D | Q9BVG8 | protein_coding | tolerated(0.1) | benign(0.029) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
KIFC3 | SNV | Missense_Mutation | | c.1964G>A | p.Arg655His | p.R655H | Q9BVG8 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
KIFC3 | SNV | Missense_Mutation | rs782343536 | c.2330C>T | p.Thr777Met | p.T777M | Q9BVG8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E2-A154-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
KIFC3 | insertion | Frame_Shift_Ins | novel | c.449_450insTACTGAGCCTTTTCCTGGTCTGGCC | p.Gly151ThrfsTer24 | p.G151Tfs*24 | Q9BVG8 | protein_coding | | | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
KIFC3 | insertion | Frame_Shift_Ins | novel | c.1021dupT | p.Ser341PhefsTer26 | p.S341Ffs*26 | Q9BVG8 | protein_coding | | | TCGA-BH-A1FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
KIFC3 | deletion | Frame_Shift_Del | novel | c.2182delG | p.Asp728ThrfsTer83 | p.D728Tfs*83 | Q9BVG8 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
KIFC3 | SNV | Missense_Mutation | rs782764063 | c.547C>T | p.Arg183Cys | p.R183C | Q9BVG8 | protein_coding | tolerated(0.05) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KIFC3 | SNV | Missense_Mutation | | c.944T>G | p.Leu315Arg | p.L315R | Q9BVG8 | protein_coding | deleterious(0.02) | possibly_damaging(0.869) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |