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Gene: KIF11 |
Gene summary for KIF11 |
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Gene information | Species | Human | Gene symbol | KIF11 | Gene ID | 3832 |
Gene name | kinesin family member 11 | |
Gene Alias | EG5 | |
Cytomap | 10q23.33 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | P52732 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3832 | KIF11 | LZE2T | Human | Esophagus | ESCC | 4.73e-03 | 4.64e-01 | 0.082 |
3832 | KIF11 | LZE4T | Human | Esophagus | ESCC | 2.37e-02 | 1.80e-01 | 0.0811 |
3832 | KIF11 | P2T-E | Human | Esophagus | ESCC | 7.29e-04 | 2.06e-01 | 0.1177 |
3832 | KIF11 | P4T-E | Human | Esophagus | ESCC | 8.00e-03 | 1.34e-01 | 0.1323 |
3832 | KIF11 | P5T-E | Human | Esophagus | ESCC | 3.93e-02 | 1.25e-01 | 0.1327 |
3832 | KIF11 | P15T-E | Human | Esophagus | ESCC | 2.11e-03 | 1.38e-01 | 0.1149 |
3832 | KIF11 | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 2.04e-01 | 0.1278 |
3832 | KIF11 | P19T-E | Human | Esophagus | ESCC | 7.48e-03 | 2.48e-01 | 0.1662 |
3832 | KIF11 | P21T-E | Human | Esophagus | ESCC | 1.23e-02 | 5.71e-02 | 0.1617 |
3832 | KIF11 | P28T-E | Human | Esophagus | ESCC | 1.69e-03 | 1.26e-01 | 0.1149 |
3832 | KIF11 | P37T-E | Human | Esophagus | ESCC | 3.53e-03 | 1.06e-01 | 0.1371 |
3832 | KIF11 | P49T-E | Human | Esophagus | ESCC | 5.57e-05 | 3.73e-01 | 0.1768 |
3832 | KIF11 | P62T-E | Human | Esophagus | ESCC | 1.21e-03 | 1.49e-01 | 0.1302 |
3832 | KIF11 | P76T-E | Human | Esophagus | ESCC | 3.51e-03 | 1.46e-01 | 0.1207 |
3832 | KIF11 | P83T-E | Human | Esophagus | ESCC | 1.35e-05 | 2.03e-01 | 0.1738 |
3832 | KIF11 | P89T-E | Human | Esophagus | ESCC | 6.02e-08 | 5.21e-01 | 0.1752 |
3832 | KIF11 | P91T-E | Human | Esophagus | ESCC | 3.13e-07 | 6.82e-01 | 0.1828 |
3832 | KIF11 | P107T-E | Human | Esophagus | ESCC | 2.08e-09 | 2.98e-01 | 0.171 |
3832 | KIF11 | P130T-E | Human | Esophagus | ESCC | 6.46e-14 | 4.68e-01 | 0.1676 |
3832 | KIF11 | HCC1_Meng | Human | Liver | HCC | 6.78e-18 | 2.38e-02 | 0.0246 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007098 | Liver | HCC | centrosome cycle | 75/7958 | 130/18723 | 3.33e-04 | 2.34e-03 | 75 |
GO:0000280 | Liver | HCC | nuclear division | 220/7958 | 439/18723 | 6.90e-04 | 4.25e-03 | 220 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF11 | SNV | Missense_Mutation | novel | c.2491N>A | p.Glu831Lys | p.E831K | P52732 | protein_coding | tolerated(0.18) | benign(0.053) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
KIF11 | SNV | Missense_Mutation | c.1798N>T | p.Val600Phe | p.V600F | P52732 | protein_coding | deleterious(0.01) | possibly_damaging(0.657) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | |
KIF11 | SNV | Missense_Mutation | c.1891G>A | p.Asp631Asn | p.D631N | P52732 | protein_coding | tolerated(0.12) | benign(0.006) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIF11 | SNV | Missense_Mutation | novel | c.248N>A | p.Arg83Gln | p.R83Q | P52732 | protein_coding | deleterious(0) | possibly_damaging(0.669) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF11 | SNV | Missense_Mutation | c.175N>A | p.Asp59Asn | p.D59N | P52732 | protein_coding | deleterious(0) | possibly_damaging(0.612) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
KIF11 | SNV | Missense_Mutation | c.1288G>C | p.Glu430Gln | p.E430Q | P52732 | protein_coding | deleterious(0.01) | possibly_damaging(0.729) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
KIF11 | SNV | Missense_Mutation | novel | c.1997N>G | p.Asp666Gly | p.D666G | P52732 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-LL-A8F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
KIF11 | insertion | Frame_Shift_Ins | novel | c.2397_2398insCGTTT | p.His800ArgfsTer25 | p.H800Rfs*25 | P52732 | protein_coding | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
KIF11 | insertion | Nonsense_Mutation | novel | c.2399_2400insTGAGCAAAGATGATC | p.His800_Ser801insGluGlnArgTerSer | p.H800_S801insEQR*S | P52732 | protein_coding | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
KIF11 | SNV | Missense_Mutation | rs201047452 | c.1996N>A | p.Asp666Asn | p.D666N | P52732 | protein_coding | tolerated(0.26) | benign(0.006) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3832 | KIF11 | DRUGGABLE GENOME | ARQ-621 | |||
3832 | KIF11 | DRUGGABLE GENOME | Ispinesib | ISPINESIB | ||
3832 | KIF11 | DRUGGABLE GENOME | 4SC-205 | |||
3832 | KIF11 | DRUGGABLE GENOME | 4SC-205 | |||
3832 | KIF11 | DRUGGABLE GENOME | ARRY-520 | FILANESIB | ||
3832 | KIF11 | DRUGGABLE GENOME | inhibitor | 223366041 | AZD-4877 | |
3832 | KIF11 | DRUGGABLE GENOME | SB-743921 | SB-743921 | ||
3832 | KIF11 | DRUGGABLE GENOME | S-TRITYL-L-CYSTEINE | S-TRITYL-L-CYSTEINE | 22749640 | |
3832 | KIF11 | DRUGGABLE GENOME | NSC-123138 | CHEMBL409102 | 21344920 | |
3832 | KIF11 | DRUGGABLE GENOME | ARQ 621 |
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