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Gene: INPP5K |
Gene summary for INPP5K |
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Gene information | Species | Human | Gene symbol | INPP5K | Gene ID | 51763 |
Gene name | inositol polyphosphate-5-phosphatase K | |
Gene Alias | MDCCAID | |
Cytomap | 17p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9BT40 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51763 | INPP5K | LZE4T | Human | Esophagus | ESCC | 4.90e-08 | 3.18e-01 | 0.0811 |
51763 | INPP5K | LZE7T | Human | Esophagus | ESCC | 2.33e-04 | 1.95e-01 | 0.0667 |
51763 | INPP5K | LZE8T | Human | Esophagus | ESCC | 1.09e-07 | 1.18e-01 | 0.067 |
51763 | INPP5K | LZE21D1 | Human | Esophagus | HGIN | 2.29e-02 | 2.25e-01 | 0.0632 |
51763 | INPP5K | LZE22T | Human | Esophagus | ESCC | 1.29e-03 | 2.91e-01 | 0.068 |
51763 | INPP5K | LZE24T | Human | Esophagus | ESCC | 2.28e-22 | 6.12e-01 | 0.0596 |
51763 | INPP5K | LZE21T | Human | Esophagus | ESCC | 2.00e-06 | 2.50e-01 | 0.0655 |
51763 | INPP5K | P1T-E | Human | Esophagus | ESCC | 9.00e-13 | 6.12e-01 | 0.0875 |
51763 | INPP5K | P2T-E | Human | Esophagus | ESCC | 1.12e-22 | 3.52e-01 | 0.1177 |
51763 | INPP5K | P4T-E | Human | Esophagus | ESCC | 4.96e-13 | 3.60e-01 | 0.1323 |
51763 | INPP5K | P5T-E | Human | Esophagus | ESCC | 1.04e-05 | 9.09e-02 | 0.1327 |
51763 | INPP5K | P8T-E | Human | Esophagus | ESCC | 7.15e-18 | 3.48e-01 | 0.0889 |
51763 | INPP5K | P9T-E | Human | Esophagus | ESCC | 1.54e-13 | 3.86e-01 | 0.1131 |
51763 | INPP5K | P10T-E | Human | Esophagus | ESCC | 2.09e-32 | 4.56e-01 | 0.116 |
51763 | INPP5K | P11T-E | Human | Esophagus | ESCC | 8.79e-14 | 5.25e-01 | 0.1426 |
51763 | INPP5K | P12T-E | Human | Esophagus | ESCC | 1.57e-29 | 4.78e-01 | 0.1122 |
51763 | INPP5K | P15T-E | Human | Esophagus | ESCC | 1.20e-09 | 1.81e-01 | 0.1149 |
51763 | INPP5K | P16T-E | Human | Esophagus | ESCC | 4.00e-25 | 4.72e-01 | 0.1153 |
51763 | INPP5K | P17T-E | Human | Esophagus | ESCC | 9.80e-12 | 4.11e-01 | 0.1278 |
51763 | INPP5K | P19T-E | Human | Esophagus | ESCC | 1.69e-13 | 6.96e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004593626 | Esophagus | HGIN | negative regulation of phosphate metabolic process | 89/2587 | 441/18723 | 1.24e-04 | 2.54e-03 | 89 |
GO:001056326 | Esophagus | HGIN | negative regulation of phosphorus metabolic process | 89/2587 | 442/18723 | 1.34e-04 | 2.71e-03 | 89 |
GO:004346718 | Esophagus | HGIN | regulation of generation of precursor metabolites and energy | 34/2587 | 130/18723 | 1.37e-04 | 2.76e-03 | 34 |
GO:190290327 | Esophagus | HGIN | regulation of supramolecular fiber organization | 79/2587 | 383/18723 | 1.40e-04 | 2.81e-03 | 79 |
GO:004232620 | Esophagus | HGIN | negative regulation of phosphorylation | 78/2587 | 385/18723 | 2.77e-04 | 4.77e-03 | 78 |
GO:00518518 | Esophagus | HGIN | modulation by host of symbiont process | 19/2587 | 60/18723 | 3.07e-04 | 5.15e-03 | 19 |
GO:00518177 | Esophagus | HGIN | modulation of process of other organism involved in symbiotic interaction | 23/2587 | 81/18723 | 4.52e-04 | 6.62e-03 | 23 |
GO:004852510 | Esophagus | HGIN | negative regulation of viral process | 25/2587 | 92/18723 | 5.41e-04 | 7.71e-03 | 25 |
GO:007084918 | Esophagus | HGIN | response to epidermal growth factor | 16/2587 | 49/18723 | 6.14e-04 | 8.56e-03 | 16 |
GO:000193320 | Esophagus | HGIN | negative regulation of protein phosphorylation | 69/2587 | 342/18723 | 6.81e-04 | 9.26e-03 | 69 |
GO:007136418 | Esophagus | HGIN | cellular response to epidermal growth factor stimulus | 15/2587 | 45/18723 | 7.05e-04 | 9.52e-03 | 15 |
GO:00358219 | Esophagus | HGIN | modulation of process of other organism | 27/2587 | 106/18723 | 9.89e-04 | 1.24e-02 | 27 |
GO:003297027 | Esophagus | HGIN | regulation of actin filament-based process | 77/2587 | 397/18723 | 1.14e-03 | 1.39e-02 | 77 |
GO:19035338 | Esophagus | HGIN | regulation of protein targeting | 22/2587 | 81/18723 | 1.14e-03 | 1.39e-02 | 22 |
GO:005134827 | Esophagus | HGIN | negative regulation of transferase activity | 55/2587 | 268/18723 | 1.51e-03 | 1.74e-02 | 55 |
GO:004343420 | Esophagus | HGIN | response to peptide hormone | 79/2587 | 414/18723 | 1.60e-03 | 1.79e-02 | 79 |
GO:005170210 | Esophagus | HGIN | biological process involved in interaction with symbiont | 24/2587 | 94/18723 | 1.78e-03 | 1.92e-02 | 24 |
GO:00396944 | Esophagus | HGIN | viral RNA genome replication | 12/2587 | 35/18723 | 1.80e-03 | 1.94e-02 | 12 |
GO:00190834 | Esophagus | HGIN | viral transcription | 15/2587 | 50/18723 | 2.35e-03 | 2.39e-02 | 15 |
GO:003295627 | Esophagus | HGIN | regulation of actin cytoskeleton organization | 69/2587 | 358/18723 | 2.35e-03 | 2.39e-02 | 69 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
INPP5K | deletion | Frame_Shift_Del | novel | c.415delN | p.Tyr139MetfsTer55 | p.Y139Mfs*55 | Q9BT40 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
INPP5K | SNV | Missense_Mutation | novel | c.258C>G | p.Ile86Met | p.I86M | Q9BT40 | protein_coding | deleterious(0.01) | possibly_damaging(0.756) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
INPP5K | SNV | Missense_Mutation | rs138972043 | c.1259N>A | p.Arg420His | p.R420H | Q9BT40 | protein_coding | tolerated(0.65) | benign(0.001) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
INPP5K | SNV | Missense_Mutation | c.809N>A | p.Arg270His | p.R270H | Q9BT40 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
INPP5K | SNV | Missense_Mutation | rs779661934 | c.212N>T | p.Ser71Leu | p.S71L | Q9BT40 | protein_coding | deleterious(0.02) | benign(0.028) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
INPP5K | SNV | Missense_Mutation | c.809G>A | p.Arg270His | p.R270H | Q9BT40 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
INPP5K | SNV | Missense_Mutation | c.112C>A | p.Leu38Met | p.L38M | Q9BT40 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-AF-6672-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Ancillary | leucovorin | PD | |
INPP5K | SNV | Missense_Mutation | novel | c.239N>C | p.Leu80Pro | p.L80P | Q9BT40 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
INPP5K | SNV | Missense_Mutation | rs756203232 | c.1258N>T | p.Arg420Cys | p.R420C | Q9BT40 | protein_coding | deleterious(0.01) | possibly_damaging(0.513) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
INPP5K | SNV | Missense_Mutation | novel | c.989N>C | p.Leu330Pro | p.L330P | Q9BT40 | protein_coding | tolerated(0.07) | benign(0.027) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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