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Gene: INCENP |
Gene summary for INCENP |
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Gene information | Species | Human | Gene symbol | INCENP | Gene ID | 3619 |
Gene name | inner centromere protein | |
Gene Alias | INCENP | |
Cytomap | 11q12.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9NQS7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3619 | INCENP | LZE24T | Human | Esophagus | ESCC | 2.65e-05 | 1.55e-01 | 0.0596 |
3619 | INCENP | P2T-E | Human | Esophagus | ESCC | 4.31e-06 | 2.07e-01 | 0.1177 |
3619 | INCENP | P4T-E | Human | Esophagus | ESCC | 7.93e-07 | 1.75e-01 | 0.1323 |
3619 | INCENP | P5T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.45e-01 | 0.1327 |
3619 | INCENP | P8T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.20e-01 | 0.0889 |
3619 | INCENP | P9T-E | Human | Esophagus | ESCC | 2.30e-02 | 1.34e-01 | 0.1131 |
3619 | INCENP | P10T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.04e-01 | 0.116 |
3619 | INCENP | P11T-E | Human | Esophagus | ESCC | 4.74e-03 | 1.45e-01 | 0.1426 |
3619 | INCENP | P17T-E | Human | Esophagus | ESCC | 2.68e-03 | 2.21e-01 | 0.1278 |
3619 | INCENP | P21T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.61e-01 | 0.1617 |
3619 | INCENP | P23T-E | Human | Esophagus | ESCC | 3.36e-03 | 1.25e-01 | 0.108 |
3619 | INCENP | P24T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.38e-01 | 0.1287 |
3619 | INCENP | P26T-E | Human | Esophagus | ESCC | 3.50e-02 | 7.71e-02 | 0.1276 |
3619 | INCENP | P27T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.28e-01 | 0.1055 |
3619 | INCENP | P28T-E | Human | Esophagus | ESCC | 4.24e-18 | 3.15e-01 | 0.1149 |
3619 | INCENP | P30T-E | Human | Esophagus | ESCC | 2.13e-03 | 1.60e-01 | 0.137 |
3619 | INCENP | P31T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.34e-01 | 0.1251 |
3619 | INCENP | P32T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.56e-01 | 0.1666 |
3619 | INCENP | P36T-E | Human | Esophagus | ESCC | 7.91e-07 | 2.35e-01 | 0.1187 |
3619 | INCENP | P37T-E | Human | Esophagus | ESCC | 4.27e-06 | 2.12e-01 | 0.1371 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003367420 | Esophagus | ESCC | positive regulation of kinase activity | 260/8552 | 467/18723 | 7.26e-06 | 7.22e-05 | 260 |
GO:00324653 | Esophagus | ESCC | regulation of cytokinesis | 57/8552 | 92/18723 | 1.20e-03 | 5.88e-03 | 57 |
GO:00165721 | Esophagus | ESCC | histone phosphorylation | 27/8552 | 39/18723 | 2.52e-03 | 1.08e-02 | 27 |
GO:00513025 | Esophagus | ESCC | regulation of cell division | 97/8552 | 177/18723 | 8.93e-03 | 3.12e-02 | 97 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
INCENP | SNV | Missense_Mutation | rs780988487 | c.2540N>A | p.Arg847Gln | p.R847Q | Q9NQS7 | protein_coding | tolerated(0.15) | possibly_damaging(0.895) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
INCENP | SNV | Missense_Mutation | c.511A>G | p.Ile171Val | p.I171V | Q9NQS7 | protein_coding | tolerated(0.2) | benign(0.012) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
INCENP | SNV | Missense_Mutation | c.1442C>T | p.Ser481Leu | p.S481L | Q9NQS7 | protein_coding | deleterious(0) | benign(0) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
INCENP | SNV | Missense_Mutation | c.1391N>G | p.Gln464Arg | p.Q464R | Q9NQS7 | protein_coding | deleterious(0.03) | benign(0.038) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
INCENP | SNV | Missense_Mutation | c.901N>G | p.Gln301Glu | p.Q301E | Q9NQS7 | protein_coding | deleterious(0.02) | benign(0.011) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD | |
INCENP | insertion | Frame_Shift_Ins | novel | c.1789_1790insTCAACTATTATGAAATAGTTGATATACACAATAGAATATATGT | p.Lys597IlefsTer18 | p.K597Ifs*18 | Q9NQS7 | protein_coding | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
INCENP | insertion | Nonsense_Mutation | novel | c.1328_1329insGGGGGTAGCCAGGCCCTGGCATCTGTAGATTTGTATTTTTAGT | p.Pro444GlyfsTer9 | p.P444Gfs*9 | Q9NQS7 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
INCENP | deletion | Frame_Shift_Del | c.1132delN | p.Glu380ArgfsTer78 | p.E380Rfs*78 | Q9NQS7 | protein_coding | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
INCENP | insertion | In_Frame_Ins | novel | c.2061_2062insGAGCGG | p.Gln687_Arg688insGluArg | p.Q687_R688insER | Q9NQS7 | protein_coding | TCGA-E2-A576-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
INCENP | SNV | Missense_Mutation | rs770503094 | c.1384G>A | p.Glu462Lys | p.E462K | Q9NQS7 | protein_coding | deleterious(0.01) | benign(0.34) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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