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Gene: IMPA2 |
Gene summary for IMPA2 |
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Gene information | Species | Human | Gene symbol | IMPA2 | Gene ID | 3613 |
Gene name | inositol monophosphatase 2 | |
Gene Alias | IMPA2 | |
Cytomap | 18p11.21 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | O14732 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3613 | IMPA2 | GSM4909281 | Human | Breast | IDC | 1.34e-18 | 5.05e-01 | 0.21 |
3613 | IMPA2 | GSM4909282 | Human | Breast | IDC | 8.30e-35 | 7.07e-01 | -0.0288 |
3613 | IMPA2 | GSM4909285 | Human | Breast | IDC | 1.47e-04 | 2.35e-01 | 0.21 |
3613 | IMPA2 | GSM4909286 | Human | Breast | IDC | 2.44e-19 | 4.63e-01 | 0.1081 |
3613 | IMPA2 | GSM4909287 | Human | Breast | IDC | 5.98e-09 | 4.32e-01 | 0.2057 |
3613 | IMPA2 | GSM4909290 | Human | Breast | IDC | 9.71e-03 | 2.78e-01 | 0.2096 |
3613 | IMPA2 | GSM4909304 | Human | Breast | IDC | 3.85e-07 | 2.63e-01 | 0.1636 |
3613 | IMPA2 | GSM4909319 | Human | Breast | IDC | 1.80e-06 | -1.27e-02 | 0.1563 |
3613 | IMPA2 | DCIS2 | Human | Breast | DCIS | 1.84e-12 | -3.66e-02 | 0.0085 |
3613 | IMPA2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.03e-05 | 2.15e-01 | 0.0155 |
3613 | IMPA2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.53e-05 | 5.49e-01 | -0.1808 |
3613 | IMPA2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.39e-02 | 3.34e-01 | -0.0811 |
3613 | IMPA2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.63e-28 | 9.46e-01 | -0.1954 |
3613 | IMPA2 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.15e-03 | 7.66e-01 | -0.2602 |
3613 | IMPA2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.51e-05 | 6.04e-01 | -0.1207 |
3613 | IMPA2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.31e-08 | 5.05e-01 | -0.1464 |
3613 | IMPA2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.53e-02 | 3.74e-01 | -0.1001 |
3613 | IMPA2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.38e-03 | 5.17e-01 | -0.059 |
3613 | IMPA2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.72e-04 | 6.61e-01 | -0.1706 |
3613 | IMPA2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.02e-04 | 5.43e-01 | -0.0179 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00442621 | Colorectum | FAP | cellular carbohydrate metabolic process | 66/2622 | 283/18723 | 1.53e-05 | 4.01e-04 | 66 |
GO:00442823 | Colorectum | FAP | small molecule catabolic process | 77/2622 | 376/18723 | 3.25e-04 | 4.16e-03 | 77 |
GO:0008654 | Colorectum | FAP | phospholipid biosynthetic process | 54/2622 | 253/18723 | 8.88e-04 | 9.08e-03 | 54 |
GO:00066502 | Colorectum | FAP | glycerophospholipid metabolic process | 62/2622 | 306/18723 | 1.54e-03 | 1.38e-02 | 62 |
GO:00066442 | Colorectum | FAP | phospholipid metabolic process | 74/2622 | 383/18723 | 2.24e-03 | 1.83e-02 | 74 |
GO:00060663 | Colorectum | FAP | alcohol metabolic process | 69/2622 | 353/18723 | 2.29e-03 | 1.85e-02 | 69 |
GO:0046474 | Colorectum | FAP | glycerophospholipid biosynthetic process | 44/2622 | 211/18723 | 3.98e-03 | 2.76e-02 | 44 |
GO:00450172 | Colorectum | FAP | glycerolipid biosynthetic process | 50/2622 | 252/18723 | 6.32e-03 | 3.95e-02 | 50 |
GO:00163114 | Colorectum | CRC | dephosphorylation | 79/2078 | 417/18723 | 1.27e-06 | 7.21e-05 | 79 |
GO:00086541 | Colorectum | CRC | phospholipid biosynthetic process | 49/2078 | 253/18723 | 7.07e-05 | 1.51e-03 | 49 |
GO:00066503 | Colorectum | CRC | glycerophospholipid metabolic process | 55/2078 | 306/18723 | 2.10e-04 | 3.55e-03 | 55 |
GO:00450173 | Colorectum | CRC | glycerolipid biosynthetic process | 47/2078 | 252/18723 | 2.47e-04 | 4.06e-03 | 47 |
GO:00066443 | Colorectum | CRC | phospholipid metabolic process | 65/2078 | 383/18723 | 3.21e-04 | 4.95e-03 | 65 |
GO:00464741 | Colorectum | CRC | glycerophospholipid biosynthetic process | 40/2078 | 211/18723 | 4.91e-04 | 7.02e-03 | 40 |
GO:00464861 | Colorectum | CRC | glycerolipid metabolic process | 64/2078 | 392/18723 | 1.01e-03 | 1.19e-02 | 64 |
GO:00442622 | Colorectum | CRC | cellular carbohydrate metabolic process | 49/2078 | 283/18723 | 1.06e-03 | 1.24e-02 | 49 |
GO:00060664 | Colorectum | CRC | alcohol metabolic process | 57/2078 | 353/18723 | 2.37e-03 | 2.27e-02 | 57 |
GO:0019751 | Colorectum | CRC | polyol metabolic process | 22/2078 | 114/18723 | 6.73e-03 | 4.77e-02 | 22 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04070 | Colorectum | CRC | Phosphatidylinositol signaling system | 25/1091 | 97/8465 | 4.27e-04 | 4.60e-03 | 3.12e-03 | 25 |
hsa00562 | Colorectum | CRC | Inositol phosphate metabolism | 18/1091 | 73/8465 | 4.38e-03 | 2.52e-02 | 1.71e-02 | 18 |
hsa040701 | Colorectum | CRC | Phosphatidylinositol signaling system | 25/1091 | 97/8465 | 4.27e-04 | 4.60e-03 | 3.12e-03 | 25 |
hsa005621 | Colorectum | CRC | Inositol phosphate metabolism | 18/1091 | 73/8465 | 4.38e-03 | 2.52e-02 | 1.71e-02 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IMPA2 | SNV | Missense_Mutation | novel | c.760N>T | p.Leu254Phe | p.L254F | O14732 | protein_coding | tolerated(1) | benign(0.018) | TCGA-AN-A0FK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
IMPA2 | SNV | Missense_Mutation | c.715N>G | p.Ile239Val | p.I239V | O14732 | protein_coding | tolerated(1) | benign(0.003) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IMPA2 | SNV | Missense_Mutation | c.825G>T | p.Gln275His | p.Q275H | O14732 | protein_coding | deleterious(0) | benign(0.394) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IMPA2 | SNV | Missense_Mutation | c.341C>A | p.Pro114Gln | p.P114Q | O14732 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-GM-A2DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
IMPA2 | insertion | Frame_Shift_Ins | novel | c.557_558insTGCTGGCATTACAGGCACGATCCACTGTG | p.Leu187AlafsTer11 | p.L187Afs*11 | O14732 | protein_coding | TCGA-B6-A0I6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
IMPA2 | SNV | Missense_Mutation | c.224N>T | p.Ser75Leu | p.S75L | O14732 | protein_coding | deleterious(0.02) | benign(0.077) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
IMPA2 | SNV | Missense_Mutation | c.313G>A | p.Gly105Ser | p.G105S | O14732 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IMPA2 | SNV | Missense_Mutation | rs754589142 | c.533N>A | p.Arg178His | p.R178H | O14732 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
IMPA2 | SNV | Missense_Mutation | c.763N>A | p.Asp255Asn | p.D255N | O14732 | protein_coding | deleterious(0.02) | benign(0.445) | TCGA-CI-6621-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
IMPA2 | insertion | Frame_Shift_Ins | novel | c.104_105insA | p.Ala37SerfsTer4 | p.A37Sfs*4 | O14732 | protein_coding | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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