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Gene: IHH |
Gene summary for IHH |
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Gene information | Species | Human | Gene symbol | IHH | Gene ID | 3549 |
Gene name | Indian hedgehog signaling molecule | |
Gene Alias | BDA1 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q14623 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3549 | IHH | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.14e-05 | 2.56e-01 | -0.1808 |
3549 | IHH | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.18e-02 | 2.38e-01 | -0.0811 |
3549 | IHH | HTA11_78_2000001011 | Human | Colorectum | AD | 1.23e-04 | 2.40e-01 | -0.1088 |
3549 | IHH | HTA11_347_2000001011 | Human | Colorectum | AD | 2.45e-15 | 3.72e-01 | -0.1954 |
3549 | IHH | HTA11_411_2000001011 | Human | Colorectum | SER | 2.81e-08 | 9.54e-01 | -0.2602 |
3549 | IHH | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.82e-04 | 2.28e-01 | -0.1207 |
3549 | IHH | HTA11_83_2000001011 | Human | Colorectum | SER | 1.11e-02 | 2.18e-01 | -0.1526 |
3549 | IHH | HTA11_696_2000001011 | Human | Colorectum | AD | 2.10e-08 | 2.56e-01 | -0.1464 |
3549 | IHH | HTA11_866_2000001011 | Human | Colorectum | AD | 7.61e-07 | 1.48e-01 | -0.1001 |
3549 | IHH | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.19e-02 | 1.94e-01 | -0.059 |
3549 | IHH | HTA11_546_2000001011 | Human | Colorectum | AD | 1.09e-04 | 3.37e-01 | -0.0842 |
3549 | IHH | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.09e-11 | 2.79e-01 | 0.0674 |
3549 | IHH | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.06e-04 | 4.27e-01 | 0.0112 |
3549 | IHH | HTA11_7469_2000001011 | Human | Colorectum | AD | 9.26e-10 | 7.08e-01 | -0.0124 |
3549 | IHH | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.02e-02 | 2.52e-01 | 0.0588 |
3549 | IHH | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.82e-11 | 3.21e-01 | 0.3859 |
3549 | IHH | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.25e-05 | 2.01e-01 | 0.3005 |
3549 | IHH | HCC2_Meng | Human | Liver | HCC | 1.07e-08 | 8.32e-02 | 0.0107 |
3549 | IHH | S014 | Human | Liver | HCC | 4.12e-18 | 6.12e-01 | 0.2254 |
3549 | IHH | S015 | Human | Liver | HCC | 9.13e-20 | 7.81e-01 | 0.2375 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016485 | Colorectum | AD | protein processing | 63/3918 | 225/18723 | 6.77e-03 | 4.19e-02 | 63 |
GO:0001503 | Colorectum | AD | ossification | 106/3918 | 408/18723 | 7.68e-03 | 4.64e-02 | 106 |
GO:0002053 | Colorectum | AD | positive regulation of mesenchymal cell proliferation | 10/3918 | 22/18723 | 8.52e-03 | 4.97e-02 | 10 |
GO:00487321 | Colorectum | SER | gland development | 112/2897 | 436/18723 | 1.75e-08 | 1.28e-06 | 112 |
GO:00020641 | Colorectum | SER | epithelial cell development | 64/2897 | 220/18723 | 1.96e-07 | 1.10e-05 | 64 |
GO:00610081 | Colorectum | SER | hepaticobiliary system development | 45/2897 | 150/18723 | 4.98e-06 | 1.85e-04 | 45 |
GO:00018891 | Colorectum | SER | liver development | 44/2897 | 147/18723 | 6.73e-06 | 2.35e-04 | 44 |
GO:00516041 | Colorectum | SER | protein maturation | 73/2897 | 294/18723 | 1.82e-05 | 5.38e-04 | 73 |
GO:00018941 | Colorectum | SER | tissue homeostasis | 66/2897 | 268/18723 | 5.87e-05 | 1.37e-03 | 66 |
GO:00602491 | Colorectum | SER | anatomical structure homeostasis | 74/2897 | 314/18723 | 1.01e-04 | 2.13e-03 | 74 |
GO:00016491 | Colorectum | SER | osteoblast differentiation | 56/2897 | 229/18723 | 2.49e-04 | 4.21e-03 | 56 |
GO:00164851 | Colorectum | SER | protein processing | 55/2897 | 225/18723 | 2.84e-04 | 4.67e-03 | 55 |
GO:00974211 | Colorectum | SER | liver regeneration | 14/2897 | 35/18723 | 4.02e-04 | 6.02e-03 | 14 |
GO:00457851 | Colorectum | SER | positive regulation of cell adhesion | 93/2897 | 437/18723 | 6.78e-04 | 9.04e-03 | 93 |
GO:0007162 | Colorectum | SER | negative regulation of cell adhesion | 68/2897 | 303/18723 | 8.02e-04 | 1.01e-02 | 68 |
GO:00487361 | Colorectum | SER | appendage development | 42/2897 | 172/18723 | 1.43e-03 | 1.55e-02 | 42 |
GO:00601731 | Colorectum | SER | limb development | 42/2897 | 172/18723 | 1.43e-03 | 1.55e-02 | 42 |
GO:00017011 | Colorectum | SER | in utero embryonic development | 77/2897 | 367/18723 | 2.77e-03 | 2.48e-02 | 77 |
GO:0022408 | Colorectum | SER | negative regulation of cell-cell adhesion | 44/2897 | 196/18723 | 6.08e-03 | 4.42e-02 | 44 |
GO:0035107 | Colorectum | SER | appendage morphogenesis | 33/2897 | 138/18723 | 6.10e-03 | 4.42e-02 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05205 | Colorectum | AD | Proteoglycans in cancer | 70/2092 | 205/8465 | 1.37e-03 | 8.46e-03 | 5.39e-03 | 70 |
hsa052051 | Colorectum | AD | Proteoglycans in cancer | 70/2092 | 205/8465 | 1.37e-03 | 8.46e-03 | 5.39e-03 | 70 |
hsa052052 | Colorectum | SER | Proteoglycans in cancer | 58/1580 | 205/8465 | 4.37e-04 | 3.82e-03 | 2.77e-03 | 58 |
hsa052053 | Colorectum | SER | Proteoglycans in cancer | 58/1580 | 205/8465 | 4.37e-04 | 3.82e-03 | 2.77e-03 | 58 |
hsa052054 | Colorectum | MSS | Proteoglycans in cancer | 65/1875 | 205/8465 | 8.66e-04 | 5.38e-03 | 3.29e-03 | 65 |
hsa052055 | Colorectum | MSS | Proteoglycans in cancer | 65/1875 | 205/8465 | 8.66e-04 | 5.38e-03 | 3.29e-03 | 65 |
hsa0520521 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
hsa0520531 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IHH | SNV | Missense_Mutation | novel | c.1021N>C | p.Glu341Gln | p.E341Q | Q14623 | protein_coding | deleterious(0) | possibly_damaging(0.492) | TCGA-C5-A2LY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
IHH | SNV | Missense_Mutation | c.842N>G | p.Asp281Gly | p.D281G | Q14623 | protein_coding | tolerated(0.27) | benign(0.239) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
IHH | SNV | Missense_Mutation | c.738N>A | p.Phe246Leu | p.F246L | Q14623 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IHH | SNV | Missense_Mutation | c.503N>A | p.Arg168His | p.R168H | Q14623 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
IHH | SNV | Missense_Mutation | c.517G>A | p.Ala173Thr | p.A173T | Q14623 | protein_coding | deleterious(0.01) | probably_damaging(0.923) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
IHH | SNV | Missense_Mutation | c.167N>C | p.Val56Ala | p.V56A | Q14623 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IHH | SNV | Missense_Mutation | novel | c.364N>A | p.Trp122Arg | p.W122R | Q14623 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IHH | SNV | Missense_Mutation | novel | c.556N>A | p.Val186Met | p.V186M | Q14623 | protein_coding | deleterious(0) | possibly_damaging(0.678) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IHH | SNV | Missense_Mutation | novel | c.446N>A | p.Arg149His | p.R149H | Q14623 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
IHH | SNV | Missense_Mutation | novel | c.343N>T | p.Ala115Ser | p.A115S | Q14623 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3549 | IHH | PROTEASE, DRUGGABLE GENOME | TGFBETA1 | 9112395 |
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