Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/IGHA1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/IGHA1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/IGHA1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/IGHA1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/IGHA1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/IGHA1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/IGHA1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/IGHA1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005125112 | Cervix | HSIL_HPV | positive regulation of lymphocyte activation | 40/737 | 362/18723 | 4.11e-09 | 6.38e-07 | 40 |
GO:000225312 | Cervix | HSIL_HPV | activation of immune response | 40/737 | 375/18723 | 1.12e-08 | 1.30e-06 | 40 |
GO:000276411 | Cervix | HSIL_HPV | immune response-regulating signaling pathway | 46/737 | 468/18723 | 1.17e-08 | 1.30e-06 | 46 |
GO:00160643 | Cervix | HSIL_HPV | immunoglobulin mediated immune response | 27/737 | 207/18723 | 4.74e-08 | 3.59e-06 | 27 |
GO:00197243 | Cervix | HSIL_HPV | B cell mediated immunity | 27/737 | 210/18723 | 6.42e-08 | 4.49e-06 | 27 |
GO:000246011 | Cervix | HSIL_HPV | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 37/737 | 356/18723 | 7.84e-08 | 5.32e-06 | 37 |
GO:00024431 | Cervix | HSIL_HPV | leukocyte mediated immunity | 41/737 | 440/18723 | 3.14e-07 | 1.76e-05 | 41 |
GO:00024493 | Cervix | HSIL_HPV | lymphocyte mediated immunity | 35/737 | 350/18723 | 4.45e-07 | 2.36e-05 | 35 |
GO:00027681 | Cervix | HSIL_HPV | immune response-regulating cell surface receptor signaling pathway | 32/737 | 315/18723 | 9.80e-07 | 4.68e-05 | 32 |
GO:001973012 | Cervix | HSIL_HPV | antimicrobial humoral response | 18/737 | 122/18723 | 1.35e-06 | 6.21e-05 | 18 |
GO:004573013 | Cervix | HSIL_HPV | respiratory burst | 9/737 | 37/18723 | 9.97e-06 | 3.41e-04 | 9 |
GO:0002429 | Cervix | HSIL_HPV | immune response-activating cell surface receptor signaling pathway | 28/737 | 291/18723 | 1.29e-05 | 4.09e-04 | 28 |
GO:0002757 | Cervix | HSIL_HPV | immune response-activating signal transduction | 28/737 | 291/18723 | 1.29e-05 | 4.09e-04 | 28 |
GO:00069091 | Cervix | HSIL_HPV | phagocytosis | 28/737 | 308/18723 | 3.63e-05 | 9.95e-04 | 28 |
GO:00069563 | Cervix | HSIL_HPV | complement activation | 16/737 | 130/18723 | 5.24e-05 | 1.29e-03 | 16 |
GO:001032411 | Cervix | HSIL_HPV | membrane invagination | 17/737 | 144/18723 | 5.28e-05 | 1.30e-03 | 17 |
GO:000189512 | Cervix | HSIL_HPV | retina homeostasis | 12/737 | 79/18723 | 5.76e-05 | 1.39e-03 | 12 |
GO:00427423 | Cervix | HSIL_HPV | defense response to bacterium | 30/737 | 350/18723 | 5.82e-05 | 1.40e-03 | 30 |
GO:000189414 | Cervix | HSIL_HPV | tissue homeostasis | 25/737 | 268/18723 | 6.17e-05 | 1.46e-03 | 25 |
GO:0002455 | Cervix | HSIL_HPV | humoral immune response mediated by circulating immunoglobulin | 15/737 | 121/18723 | 8.19e-05 | 1.84e-03 | 15 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGHA1 | SNV | Missense_Mutation | rs587723177 | c.820N>A | p.Glu274Lys | p.E274K | P01876 | IG_C_gene | tolerated(0.19) | benign(0.276) | TCGA-BH-A0W4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGHA1 | SNV | Missense_Mutation | rs771398040 | c.403N>A | p.Glu135Lys | p.E135K | P01876 | IG_C_gene | deleterious(0.01) | probably_damaging(0.984) | TCGA-C8-A130-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
IGHA1 | SNV | Missense_Mutation | rs768421910 | c.419N>A | p.Gly140Asp | p.G140D | P01876 | IG_C_gene | tolerated(0.07) | possibly_damaging(0.575) | TCGA-E2-A14S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
IGHA1 | SNV | Missense_Mutation | novel | c.390C>A | p.His130Gln | p.H130Q | P01876 | IG_C_gene | tolerated(0.8) | benign(0.006) | TCGA-E9-A228-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
IGHA1 | SNV | Missense_Mutation | novel | c.859N>A | p.Gln287Lys | p.Q287K | P01876 | IG_C_gene | tolerated(0.12) | benign(0.17) | TCGA-LL-A5YP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
IGHA1 | SNV | Missense_Mutation | rs1128904 | c.361N>C | p.Ser121Pro | p.S121P | P01876 | IG_C_gene | tolerated(0.33) | benign(0) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
IGHA1 | SNV | Missense_Mutation | novel | c.808N>A | p.Glu270Lys | p.E270K | P01876 | IG_C_gene | tolerated(0.1) | possibly_damaging(0.498) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
IGHA1 | SNV | Missense_Mutation | novel | c.972C>A | p.Phe324Leu | p.F324L | P01876 | IG_C_gene | deleterious(0) | probably_damaging(0.999) | TCGA-JW-A69B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
IGHA1 | SNV | Missense_Mutation | novel | c.1042N>A | p.Val348Met | p.V348M | P01876 | IG_C_gene | deleterious(0.04) | possibly_damaging(0.617) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
IGHA1 | SNV | Missense_Mutation | rs587723177 | c.820G>A | p.Glu274Lys | p.E274K | P01876 | IG_C_gene | tolerated(0.19) | benign(0.276) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |