Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/HOOK1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/HOOK1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/HOOK1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/HOOK1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000704111 | Liver | Cirrhotic | lysosomal transport | 50/4634 | 114/18723 | 6.15e-06 | 9.82e-05 | 50 |
GO:0007040 | Liver | Cirrhotic | lysosome organization | 35/4634 | 74/18723 | 2.10e-05 | 2.77e-04 | 35 |
GO:0080171 | Liver | Cirrhotic | lytic vacuole organization | 35/4634 | 74/18723 | 2.10e-05 | 2.77e-04 | 35 |
GO:00989274 | Liver | Cirrhotic | vesicle-mediated transport between endosomal compartments | 23/4634 | 43/18723 | 4.90e-05 | 5.65e-04 | 23 |
GO:00450223 | Liver | Cirrhotic | early endosome to late endosome transport | 21/4634 | 40/18723 | 1.48e-04 | 1.42e-03 | 21 |
GO:003070511 | Liver | Cirrhotic | cytoskeleton-dependent intracellular transport | 68/4634 | 195/18723 | 9.54e-04 | 6.77e-03 | 68 |
GO:0008333 | Liver | Cirrhotic | endosome to lysosome transport | 24/4634 | 55/18723 | 1.67e-03 | 1.07e-02 | 24 |
GO:001605021 | Liver | HCC | vesicle organization | 194/7958 | 300/18723 | 5.58e-15 | 3.97e-13 | 194 |
GO:001648221 | Liver | HCC | cytosolic transport | 117/7958 | 168/18723 | 8.83e-13 | 4.48e-11 | 117 |
GO:000703421 | Liver | HCC | vacuolar transport | 108/7958 | 157/18723 | 2.22e-11 | 8.69e-10 | 108 |
GO:000703311 | Liver | HCC | vacuole organization | 119/7958 | 180/18723 | 1.22e-10 | 4.25e-09 | 119 |
GO:000703211 | Liver | HCC | endosome organization | 61/7958 | 82/18723 | 4.36e-09 | 1.15e-07 | 61 |
GO:00070302 | Liver | HCC | Golgi organization | 99/7958 | 157/18723 | 1.54e-07 | 2.85e-06 | 99 |
GO:000704121 | Liver | HCC | lysosomal transport | 76/7958 | 114/18723 | 1.56e-07 | 2.88e-06 | 76 |
GO:009892711 | Liver | HCC | vesicle-mediated transport between endosomal compartments | 32/7958 | 43/18723 | 2.16e-05 | 2.30e-04 | 32 |
GO:004502211 | Liver | HCC | early endosome to late endosome transport | 30/7958 | 40/18723 | 3.04e-05 | 3.12e-04 | 30 |
GO:003070521 | Liver | HCC | cytoskeleton-dependent intracellular transport | 111/7958 | 195/18723 | 3.25e-05 | 3.28e-04 | 111 |
GO:00070401 | Liver | HCC | lysosome organization | 47/7958 | 74/18723 | 2.13e-04 | 1.63e-03 | 47 |
GO:00801711 | Liver | HCC | lytic vacuole organization | 47/7958 | 74/18723 | 2.13e-04 | 1.63e-03 | 47 |
GO:00083331 | Liver | HCC | endosome to lysosome transport | 35/7958 | 55/18723 | 1.26e-03 | 6.92e-03 | 35 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HOOK1 | SNV | Missense_Mutation | novel | c.436N>A | p.Glu146Lys | p.E146K | Q9UJC3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
HOOK1 | SNV | Missense_Mutation | novel | c.97G>T | p.Asp33Tyr | p.D33Y | Q9UJC3 | protein_coding | deleterious(0) | possibly_damaging(0.616) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOOK1 | SNV | Missense_Mutation | rs367708992 | c.850G>A | p.Glu284Lys | p.E284K | Q9UJC3 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOOK1 | SNV | Missense_Mutation | | c.1261G>C | p.Asp421His | p.D421H | Q9UJC3 | protein_coding | deleterious(0.02) | possibly_damaging(0.795) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
HOOK1 | SNV | Missense_Mutation | | c.1951N>A | p.Glu651Lys | p.E651K | Q9UJC3 | protein_coding | deleterious(0.01) | possibly_damaging(0.826) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
HOOK1 | SNV | Missense_Mutation | rs746529091 | c.1621N>A | p.Glu541Lys | p.E541K | Q9UJC3 | protein_coding | tolerated(0.25) | benign(0.167) | TCGA-BH-A0H7-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |
HOOK1 | SNV | Missense_Mutation | | c.213N>C | p.Trp71Cys | p.W71C | Q9UJC3 | protein_coding | deleterious(0.02) | benign(0.146) | TCGA-C8-A1HJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HOOK1 | SNV | Missense_Mutation | | c.598A>G | p.Arg200Gly | p.R200G | Q9UJC3 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-EW-A1PH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
HOOK1 | SNV | Missense_Mutation | novel | c.868N>C | p.Asp290His | p.D290H | Q9UJC3 | protein_coding | deleterious(0.04) | benign(0.178) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
HOOK1 | SNV | Missense_Mutation | rs370424578 | c.2105N>A | p.Arg702Gln | p.R702Q | Q9UJC3 | protein_coding | tolerated(1) | benign(0.021) | TCGA-C5-A905-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |