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Gene: HNRNPH2 |
Gene summary for HNRNPH2 |
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Gene information | Species | Human | Gene symbol | HNRNPH2 | Gene ID | 3188 |
Gene name | heterogeneous nuclear ribonucleoprotein H2 | |
Gene Alias | FTP3 | |
Cytomap | Xq22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P55795 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3188 | HNRNPH2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.37e-03 | 1.70e-01 | -0.1088 |
3188 | HNRNPH2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.85e-07 | 2.55e-01 | -0.1954 |
3188 | HNRNPH2 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.70e-08 | 3.09e-01 | 0.096 |
3188 | HNRNPH2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.15e-02 | 2.99e-01 | 0.0131 |
3188 | HNRNPH2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.60e-04 | 5.86e-01 | 0.0171 |
3188 | HNRNPH2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.95e-16 | 4.12e-01 | 0.294 |
3188 | HNRNPH2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.32e-05 | 3.04e-01 | 0.281 |
3188 | HNRNPH2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.05e-06 | 3.55e-01 | 0.3859 |
3188 | HNRNPH2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.59e-04 | 2.27e-01 | 0.3005 |
3188 | HNRNPH2 | LZE4T | Human | Esophagus | ESCC | 8.47e-20 | 5.50e-01 | 0.0811 |
3188 | HNRNPH2 | LZE7T | Human | Esophagus | ESCC | 5.31e-07 | 6.01e-01 | 0.0667 |
3188 | HNRNPH2 | LZE8T | Human | Esophagus | ESCC | 1.77e-08 | 2.60e-01 | 0.067 |
3188 | HNRNPH2 | LZE20T | Human | Esophagus | ESCC | 7.44e-12 | 3.95e-01 | 0.0662 |
3188 | HNRNPH2 | LZE22T | Human | Esophagus | ESCC | 6.98e-06 | 3.65e-01 | 0.068 |
3188 | HNRNPH2 | LZE24T | Human | Esophagus | ESCC | 1.39e-28 | 8.73e-01 | 0.0596 |
3188 | HNRNPH2 | LZE21T | Human | Esophagus | ESCC | 2.06e-03 | 4.48e-01 | 0.0655 |
3188 | HNRNPH2 | LZE6T | Human | Esophagus | ESCC | 1.77e-10 | 5.11e-01 | 0.0845 |
3188 | HNRNPH2 | P1T-E | Human | Esophagus | ESCC | 4.45e-02 | 3.97e-01 | 0.0875 |
3188 | HNRNPH2 | P2T-E | Human | Esophagus | ESCC | 2.46e-19 | 2.16e-01 | 0.1177 |
3188 | HNRNPH2 | P4T-E | Human | Esophagus | ESCC | 1.01e-17 | 2.53e-01 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380113 | Thyroid | PTC | RNA splicing | 273/5968 | 434/18723 | 4.44e-41 | 1.40e-37 | 273 |
GO:0043484113 | Thyroid | PTC | regulation of RNA splicing | 102/5968 | 148/18723 | 2.03e-20 | 3.21e-18 | 102 |
GO:000838034 | Thyroid | ATC | RNA splicing | 270/6293 | 434/18723 | 7.50e-35 | 1.19e-31 | 270 |
GO:004348435 | Thyroid | ATC | regulation of RNA splicing | 100/6293 | 148/18723 | 2.75e-17 | 2.72e-15 | 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPH2 | SNV | Missense_Mutation | c.431N>T | p.Pro144Leu | p.P144L | P55795 | protein_coding | tolerated(0.11) | benign(0.097) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HNRNPH2 | SNV | Missense_Mutation | c.1329N>A | p.Asp443Glu | p.D443E | P55795 | protein_coding | tolerated_low_confidence(0.06) | benign(0.092) | TCGA-AO-A0J4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
HNRNPH2 | SNV | Missense_Mutation | c.58N>A | p.Trp20Arg | p.W20R | P55795 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-C8-A12L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HNRNPH2 | SNV | Missense_Mutation | rs781979799 | c.97N>A | p.Asp33Asn | p.D33N | P55795 | protein_coding | tolerated(0.1) | benign(0.018) | TCGA-D8-A4Z1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
HNRNPH2 | SNV | Missense_Mutation | c.1243C>A | p.Gln415Lys | p.Q415K | P55795 | protein_coding | tolerated(0.47) | benign(0.026) | TCGA-E2-A14P-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | trastuzumab | SD | |
HNRNPH2 | SNV | Missense_Mutation | c.629N>T | p.Tyr210Phe | p.Y210F | P55795 | protein_coding | deleterious(0.02) | possibly_damaging(0.515) | TCGA-LL-A441-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
HNRNPH2 | SNV | Missense_Mutation | novel | c.436G>A | p.Asp146Asn | p.D146N | P55795 | protein_coding | deleterious(0.03) | probably_damaging(0.991) | TCGA-PL-A8LZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
HNRNPH2 | SNV | Missense_Mutation | rs886039764 | c.617N>A | p.Arg206Gln | p.R206Q | P55795 | protein_coding | tolerated(0.09) | benign(0.025) | TCGA-WL-A834-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
HNRNPH2 | SNV | Missense_Mutation | c.875N>G | p.His292Arg | p.H292R | P55795 | protein_coding | tolerated(0.07) | benign(0.176) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
HNRNPH2 | SNV | Missense_Mutation | c.733N>C | p.Asp245His | p.D245H | P55795 | protein_coding | tolerated(0.11) | benign(0.014) | TCGA-EI-6885-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatinum+5-fu | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3188 | HNRNPH2 | NA | migalastat | MIGALASTAT |
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