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Gene: HNRNPA0 |
Gene summary for HNRNPA0 |
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Gene information | Species | Human | Gene symbol | HNRNPA0 | Gene ID | 10949 |
Gene name | heterogeneous nuclear ribonucleoprotein A0 | |
Gene Alias | HNRPA0 | |
Cytomap | 5q31.2 | |
Gene Type | protein-coding | GO ID | GO:0002237 | UniProtAcc | Q13151 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10949 | HNRNPA0 | GSM4909277 | Human | Breast | Precancer | 3.36e-04 | 3.20e-01 | 0.0177 |
10949 | HNRNPA0 | GSM4909282 | Human | Breast | IDC | 8.45e-08 | 2.65e-01 | -0.0288 |
10949 | HNRNPA0 | GSM4909286 | Human | Breast | IDC | 2.10e-04 | 1.30e-01 | 0.1081 |
10949 | HNRNPA0 | GSM4909290 | Human | Breast | IDC | 1.35e-03 | -3.89e-01 | 0.2096 |
10949 | HNRNPA0 | GSM4909294 | Human | Breast | IDC | 6.68e-06 | -2.67e-01 | 0.2022 |
10949 | HNRNPA0 | GSM4909296 | Human | Breast | IDC | 1.93e-20 | -4.91e-01 | 0.1524 |
10949 | HNRNPA0 | GSM4909297 | Human | Breast | IDC | 1.95e-21 | -1.32e-01 | 0.1517 |
10949 | HNRNPA0 | GSM4909301 | Human | Breast | IDC | 1.19e-04 | -2.74e-01 | 0.1577 |
10949 | HNRNPA0 | GSM4909302 | Human | Breast | IDC | 7.47e-05 | -3.56e-01 | 0.1545 |
10949 | HNRNPA0 | GSM4909304 | Human | Breast | IDC | 4.64e-05 | -3.82e-01 | 0.1636 |
10949 | HNRNPA0 | GSM4909308 | Human | Breast | IDC | 1.22e-04 | 2.98e-01 | 0.158 |
10949 | HNRNPA0 | GSM4909309 | Human | Breast | IDC | 1.17e-04 | -8.06e-02 | 0.0483 |
10949 | HNRNPA0 | GSM4909311 | Human | Breast | IDC | 8.20e-45 | -4.20e-01 | 0.1534 |
10949 | HNRNPA0 | GSM4909312 | Human | Breast | IDC | 3.19e-17 | 1.88e-01 | 0.1552 |
10949 | HNRNPA0 | GSM4909313 | Human | Breast | IDC | 2.44e-10 | 2.54e-01 | 0.0391 |
10949 | HNRNPA0 | GSM4909315 | Human | Breast | IDC | 2.44e-02 | -3.24e-01 | 0.21 |
10949 | HNRNPA0 | GSM4909316 | Human | Breast | IDC | 2.87e-05 | -3.54e-01 | 0.21 |
10949 | HNRNPA0 | GSM4909318 | Human | Breast | IDC | 4.27e-04 | 1.98e-01 | 0.2031 |
10949 | HNRNPA0 | GSM4909319 | Human | Breast | IDC | 5.01e-58 | -3.12e-01 | 0.1563 |
10949 | HNRNPA0 | GSM4909320 | Human | Breast | IDC | 1.47e-14 | -7.07e-01 | 0.1575 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000223712 | Breast | IDC | response to molecule of bacterial origin | 49/1434 | 363/18723 | 7.40e-05 | 1.47e-03 | 49 |
GO:190331113 | Breast | IDC | regulation of mRNA metabolic process | 40/1434 | 288/18723 | 1.79e-04 | 3.01e-03 | 40 |
GO:003133014 | Breast | IDC | negative regulation of cellular catabolic process | 37/1434 | 262/18723 | 2.20e-04 | 3.52e-03 | 37 |
GO:000640113 | Breast | IDC | RNA catabolic process | 38/1434 | 278/18723 | 3.54e-04 | 5.16e-03 | 38 |
GO:000640213 | Breast | IDC | mRNA catabolic process | 33/1434 | 232/18723 | 4.12e-04 | 5.66e-03 | 33 |
GO:000989514 | Breast | IDC | negative regulation of catabolic process | 40/1434 | 320/18723 | 1.49e-03 | 1.50e-02 | 40 |
GO:190331214 | Breast | IDC | negative regulation of mRNA metabolic process | 16/1434 | 92/18723 | 1.57e-03 | 1.56e-02 | 16 |
GO:190136112 | Breast | IDC | organic cyclic compound catabolic process | 56/1434 | 495/18723 | 2.12e-03 | 1.99e-02 | 56 |
GO:004670012 | Breast | IDC | heterocycle catabolic process | 51/1434 | 445/18723 | 2.51e-03 | 2.25e-02 | 51 |
GO:003465513 | Breast | IDC | nucleobase-containing compound catabolic process | 47/1434 | 407/18723 | 3.12e-03 | 2.63e-02 | 47 |
GO:004427012 | Breast | IDC | cellular nitrogen compound catabolic process | 50/1434 | 451/18723 | 5.29e-03 | 3.93e-02 | 50 |
GO:001943912 | Breast | IDC | aromatic compound catabolic process | 51/1434 | 467/18723 | 6.54e-03 | 4.59e-02 | 51 |
GO:003249621 | Breast | DCIS | response to lipopolysaccharide | 46/1390 | 343/18723 | 6.83e-05 | 1.35e-03 | 46 |
GO:000223722 | Breast | DCIS | response to molecule of bacterial origin | 48/1390 | 363/18723 | 6.84e-05 | 1.35e-03 | 48 |
GO:190331123 | Breast | DCIS | regulation of mRNA metabolic process | 40/1390 | 288/18723 | 9.26e-05 | 1.71e-03 | 40 |
GO:003133024 | Breast | DCIS | negative regulation of cellular catabolic process | 37/1390 | 262/18723 | 1.18e-04 | 2.07e-03 | 37 |
GO:000640123 | Breast | DCIS | RNA catabolic process | 38/1390 | 278/18723 | 1.91e-04 | 3.08e-03 | 38 |
GO:000640223 | Breast | DCIS | mRNA catabolic process | 33/1390 | 232/18723 | 2.35e-04 | 3.70e-03 | 33 |
GO:000989524 | Breast | DCIS | negative regulation of catabolic process | 40/1390 | 320/18723 | 8.29e-04 | 9.46e-03 | 40 |
GO:190331224 | Breast | DCIS | negative regulation of mRNA metabolic process | 16/1390 | 92/18723 | 1.13e-03 | 1.22e-02 | 16 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPA0 | SNV | Missense_Mutation | c.263C>T | p.Ser88Leu | p.S88L | Q13151 | protein_coding | deleterious(0.01) | possibly_damaging(0.474) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
HNRNPA0 | SNV | Missense_Mutation | novel | c.415C>T | p.Arg139Cys | p.R139C | Q13151 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
HNRNPA0 | SNV | Missense_Mutation | novel | c.414N>T | p.Lys138Asn | p.K138N | Q13151 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
HNRNPA0 | SNV | Missense_Mutation | c.333N>T | p.Glu111Asp | p.E111D | Q13151 | protein_coding | deleterious(0.04) | benign(0.018) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
HNRNPA0 | SNV | Missense_Mutation | novel | c.411N>T | p.Lys137Asn | p.K137N | Q13151 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HNRNPA0 | SNV | Missense_Mutation | novel | c.695N>G | p.Asn232Ser | p.N232S | Q13151 | protein_coding | tolerated(0.64) | benign(0.012) | TCGA-AX-A1CJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HNRNPA0 | SNV | Missense_Mutation | novel | c.133A>G | p.Lys45Glu | p.K45E | Q13151 | protein_coding | deleterious(0.01) | benign(0.25) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HNRNPA0 | SNV | Missense_Mutation | novel | c.190N>A | p.Ala64Thr | p.A64T | Q13151 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-BS-A0VI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HNRNPA0 | SNV | Missense_Mutation | novel | c.384N>T | p.Glu128Asp | p.E128D | Q13151 | protein_coding | tolerated(0.07) | benign(0.392) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HNRNPA0 | SNV | Missense_Mutation | c.191N>G | p.Ala64Gly | p.A64G | Q13151 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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