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Gene: GPX3 |
Gene summary for GPX3 |
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Gene information | Species | Human | Gene symbol | GPX3 | Gene ID | 2878 |
Gene name | glutathione peroxidase 3 | |
Gene Alias | GPx-P | |
Cytomap | 5q33.1 | |
Gene Type | protein-coding | GO ID | GO:0006950 | UniProtAcc | P22352 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2878 | GPX3 | LZE2T | Human | Esophagus | ESCC | 3.78e-17 | 1.56e-01 | 0.082 |
2878 | GPX3 | LZE4T | Human | Esophagus | ESCC | 2.64e-04 | 3.85e-01 | 0.0811 |
2878 | GPX3 | LZE7T | Human | Esophagus | ESCC | 9.73e-03 | -3.71e-01 | 0.0667 |
2878 | GPX3 | LZE8T | Human | Esophagus | ESCC | 3.05e-04 | -4.52e-01 | 0.067 |
2878 | GPX3 | LZE20T | Human | Esophagus | ESCC | 1.15e-02 | -4.03e-01 | 0.0662 |
2878 | GPX3 | LZE24T | Human | Esophagus | ESCC | 4.06e-05 | -3.98e-01 | 0.0596 |
2878 | GPX3 | LZE6T | Human | Esophagus | ESCC | 3.11e-02 | -4.52e-01 | 0.0845 |
2878 | GPX3 | P2T-E | Human | Esophagus | ESCC | 1.56e-10 | -2.20e-01 | 0.1177 |
2878 | GPX3 | P5T-E | Human | Esophagus | ESCC | 7.72e-07 | 1.46e-01 | 0.1327 |
2878 | GPX3 | P9T-E | Human | Esophagus | ESCC | 3.09e-02 | 3.78e-02 | 0.1131 |
2878 | GPX3 | P10T-E | Human | Esophagus | ESCC | 1.37e-08 | -3.97e-01 | 0.116 |
2878 | GPX3 | P16T-E | Human | Esophagus | ESCC | 6.95e-12 | -3.69e-01 | 0.1153 |
2878 | GPX3 | P20T-E | Human | Esophagus | ESCC | 1.13e-02 | -2.56e-01 | 0.1124 |
2878 | GPX3 | P22T-E | Human | Esophagus | ESCC | 1.12e-05 | -4.06e-01 | 0.1236 |
2878 | GPX3 | P26T-E | Human | Esophagus | ESCC | 1.02e-03 | -1.65e-01 | 0.1276 |
2878 | GPX3 | P32T-E | Human | Esophagus | ESCC | 8.35e-13 | 4.32e-01 | 0.1666 |
2878 | GPX3 | P36T-E | Human | Esophagus | ESCC | 1.69e-02 | -3.86e-01 | 0.1187 |
2878 | GPX3 | P37T-E | Human | Esophagus | ESCC | 8.94e-03 | 8.94e-02 | 0.1371 |
2878 | GPX3 | P39T-E | Human | Esophagus | ESCC | 1.61e-08 | -4.22e-01 | 0.0894 |
2878 | GPX3 | P42T-E | Human | Esophagus | ESCC | 1.96e-03 | -8.72e-02 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697920 | Oral cavity | OSCC | response to oxidative stress | 273/7305 | 446/18723 | 8.35e-22 | 1.65e-19 | 273 |
GO:000963618 | Oral cavity | OSCC | response to toxic substance | 137/7305 | 262/18723 | 7.94e-06 | 8.52e-05 | 137 |
GO:007259316 | Oral cavity | OSCC | reactive oxygen species metabolic process | 122/7305 | 239/18723 | 9.73e-05 | 7.34e-04 | 122 |
GO:199074818 | Oral cavity | OSCC | cellular detoxification | 63/7305 | 116/18723 | 5.80e-04 | 3.31e-03 | 63 |
GO:009886918 | Oral cavity | OSCC | cellular oxidant detoxification | 55/7305 | 101/18723 | 1.16e-03 | 5.89e-03 | 55 |
GO:009723718 | Oral cavity | OSCC | cellular response to toxic substance | 65/7305 | 124/18723 | 1.63e-03 | 7.74e-03 | 65 |
GO:009875418 | Oral cavity | OSCC | detoxification | 75/7305 | 152/18723 | 5.99e-03 | 2.28e-02 | 75 |
GO:000697933 | Oral cavity | NEOLP | response to oxidative stress | 94/2005 | 446/18723 | 7.53e-11 | 8.58e-09 | 94 |
GO:009886931 | Oral cavity | NEOLP | cellular oxidant detoxification | 30/2005 | 101/18723 | 1.30e-07 | 4.62e-06 | 30 |
GO:000963633 | Oral cavity | NEOLP | response to toxic substance | 56/2005 | 262/18723 | 3.13e-07 | 9.85e-06 | 56 |
GO:199074832 | Oral cavity | NEOLP | cellular detoxification | 32/2005 | 116/18723 | 3.30e-07 | 1.03e-05 | 32 |
GO:009723732 | Oral cavity | NEOLP | cellular response to toxic substance | 33/2005 | 124/18723 | 5.39e-07 | 1.61e-05 | 33 |
GO:009875432 | Oral cavity | NEOLP | detoxification | 36/2005 | 152/18723 | 3.42e-06 | 7.61e-05 | 36 |
GO:007259332 | Oral cavity | NEOLP | reactive oxygen species metabolic process | 46/2005 | 239/18723 | 5.77e-05 | 7.77e-04 | 46 |
GO:004274314 | Oral cavity | NEOLP | hydrogen peroxide metabolic process | 15/2005 | 58/18723 | 9.07e-04 | 7.10e-03 | 15 |
GO:00427446 | Oral cavity | NEOLP | hydrogen peroxide catabolic process | 9/2005 | 32/18723 | 5.18e-03 | 2.78e-02 | 9 |
GO:000697930 | Thyroid | HT | response to oxidative stress | 81/1272 | 446/18723 | 2.53e-16 | 1.17e-13 | 81 |
GO:000963627 | Thyroid | HT | response to toxic substance | 50/1272 | 262/18723 | 2.25e-11 | 3.75e-09 | 50 |
GO:199074827 | Thyroid | HT | cellular detoxification | 31/1272 | 116/18723 | 2.29e-11 | 3.75e-09 | 31 |
GO:009875420 | Thyroid | HT | detoxification | 36/1272 | 152/18723 | 2.63e-11 | 4.07e-09 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa05016210 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0048018 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0501638 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0048019 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
hsa0501614 | Liver | Cirrhotic | Huntington disease | 172/2530 | 306/8465 | 1.65e-22 | 1.10e-20 | 6.77e-21 | 172 |
hsa0501414 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0502214 | Liver | Cirrhotic | Pathways of neurodegeneration - multiple diseases | 217/2530 | 476/8465 | 7.30e-14 | 2.03e-12 | 1.25e-12 | 217 |
hsa004809 | Liver | Cirrhotic | Glutathione metabolism | 30/2530 | 57/8465 | 2.63e-04 | 1.72e-03 | 1.06e-03 | 30 |
hsa0501615 | Liver | Cirrhotic | Huntington disease | 172/2530 | 306/8465 | 1.65e-22 | 1.10e-20 | 6.77e-21 | 172 |
hsa0501415 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0502215 | Liver | Cirrhotic | Pathways of neurodegeneration - multiple diseases | 217/2530 | 476/8465 | 7.30e-14 | 2.03e-12 | 1.25e-12 | 217 |
hsa0048012 | Liver | Cirrhotic | Glutathione metabolism | 30/2530 | 57/8465 | 2.63e-04 | 1.72e-03 | 1.06e-03 | 30 |
hsa0501622 | Liver | HCC | Huntington disease | 219/4020 | 306/8465 | 3.06e-18 | 3.42e-16 | 1.90e-16 | 219 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0502222 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0048022 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPX3 | SNV | Missense_Mutation | rs773898104 | c.314N>A | p.Gly105Glu | p.G105E | P22352 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPX3 | insertion | Nonsense_Mutation | novel | c.529_530insTCCTTTCTCCCTAGCTGGGGTAGAAT | p.His177LeufsTer? | p.H177Lfs*? | P22352 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
GPX3 | insertion | In_Frame_Ins | novel | c.531_532insAGA | p.His177_Asp178insArg | p.H177_D178insR | P22352 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
GPX3 | insertion | Nonsense_Mutation | novel | c.335_336insTTAGCAAAATAAGTCATT | p.Asn112_Ser113insTer | p.N112_S113ins* | P22352 | protein_coding | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GPX3 | SNV | Missense_Mutation | rs560735748 | c.608N>T | p.Thr203Met | p.T203M | P22352 | protein_coding | deleterious(0.04) | benign(0.042) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPX3 | SNV | Missense_Mutation | c.631A>G | p.Ile211Val | p.I211V | P22352 | protein_coding | deleterious(0.03) | benign(0.055) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GPX3 | SNV | Missense_Mutation | c.659N>T | p.Ala220Val | p.A220V | P22352 | protein_coding | tolerated(0.19) | benign(0) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GPX3 | SNV | Missense_Mutation | c.539G>A | p.Arg180His | p.R180H | P22352 | protein_coding | deleterious(0.01) | possibly_damaging(0.511) | TCGA-AG-3898-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GPX3 | SNV | Missense_Mutation | c.566N>T | p.Gly189Val | p.G189V | P22352 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
GPX3 | SNV | Missense_Mutation | novel | c.479N>T | p.Ser160Leu | p.S160L | P22352 | protein_coding | deleterious(0.01) | benign(0.203) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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