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Gene: GPSM1 |
Gene summary for GPSM1 |
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Gene information | Species | Human | Gene symbol | GPSM1 | Gene ID | 26086 |
Gene name | G protein signaling modulator 1 | |
Gene Alias | AGS3 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | A0A0A0MSK4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26086 | GPSM1 | male-WTA | Human | Thyroid | PTC | 3.97e-03 | 5.19e-02 | 0.1037 |
26086 | GPSM1 | PTC06 | Human | Thyroid | PTC | 2.26e-06 | 1.72e-01 | 0.2057 |
26086 | GPSM1 | PTC07 | Human | Thyroid | PTC | 4.28e-04 | 8.30e-02 | 0.2044 |
26086 | GPSM1 | ATC09 | Human | Thyroid | ATC | 2.95e-02 | 1.38e-01 | 0.2871 |
26086 | GPSM1 | ATC12 | Human | Thyroid | ATC | 5.14e-03 | 8.62e-02 | 0.34 |
26086 | GPSM1 | ATC13 | Human | Thyroid | ATC | 1.55e-34 | 5.99e-01 | 0.34 |
26086 | GPSM1 | ATC1 | Human | Thyroid | ATC | 1.55e-03 | 1.78e-01 | 0.2878 |
26086 | GPSM1 | ATC2 | Human | Thyroid | ATC | 3.71e-05 | 3.58e-01 | 0.34 |
26086 | GPSM1 | ATC4 | Human | Thyroid | ATC | 2.34e-04 | 1.15e-01 | 0.34 |
26086 | GPSM1 | ATC5 | Human | Thyroid | ATC | 4.80e-33 | 6.47e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004308719 | Thyroid | ATC | regulation of GTPase activity | 153/6293 | 348/18723 | 3.24e-05 | 2.68e-04 | 153 |
GO:001623912 | Thyroid | ATC | positive regulation of macroautophagy | 37/6293 | 63/18723 | 3.73e-05 | 3.05e-04 | 37 |
GO:005134629 | Thyroid | ATC | negative regulation of hydrolase activity | 155/6293 | 379/18723 | 1.64e-03 | 8.23e-03 | 155 |
GO:19044241 | Thyroid | ATC | regulation of GTP binding | 10/6293 | 15/18723 | 9.05e-03 | 3.39e-02 | 10 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPSM1 | SNV | Missense_Mutation | c.178N>A | p.Glu60Lys | p.E60K | protein_coding | deleterious(0) | possibly_damaging(0.884) | TCGA-D8-A1XM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GPSM1 | deletion | In_Frame_Del | c.918_938delNNNNNNNNNNNNNNNNNNNNN | p.Ala308_Arg314del | p.A308_R314del | protein_coding | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | ||||
GPSM1 | SNV | Missense_Mutation | novel | c.1807C>T | p.Leu603Phe | p.L603F | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GPSM1 | SNV | Missense_Mutation | novel | c.982N>A | p.Glu328Lys | p.E328K | protein_coding | deleterious(0) | possibly_damaging(0.614) | TCGA-VS-A9V3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
GPSM1 | SNV | Missense_Mutation | c.770N>G | p.Asn257Ser | p.N257S | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
GPSM1 | SNV | Missense_Mutation | rs782663989 | c.1784C>T | p.Pro595Leu | p.P595L | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GPSM1 | SNV | Missense_Mutation | rs782116136 | c.1653N>A | p.Phe551Leu | p.F551L | protein_coding | tolerated(0.36) | benign(0.028) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GPSM1 | SNV | Missense_Mutation | rs764332882 | c.1946N>A | p.Arg649Gln | p.R649Q | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
GPSM1 | SNV | Missense_Mutation | novel | c.967N>A | p.Ala323Thr | p.A323T | protein_coding | tolerated(0.58) | benign(0.02) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
GPSM1 | SNV | Missense_Mutation | novel | c.1220A>T | p.Lys407Met | p.K407M | protein_coding | deleterious(0.04) | probably_damaging(0.979) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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