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Gene: GNA11 |
Gene summary for GNA11 |
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Gene information | Species | Human | Gene symbol | GNA11 | Gene ID | 2767 |
Gene name | G protein subunit alpha 11 | |
Gene Alias | FBH | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P29992 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2767 | GNA11 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.04e-10 | 6.35e-01 | -0.1808 |
2767 | GNA11 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.86e-18 | 5.78e-01 | -0.1954 |
2767 | GNA11 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.78e-04 | 8.70e-01 | -0.2196 |
2767 | GNA11 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.62e-05 | 4.49e-01 | -0.1207 |
2767 | GNA11 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.95e-04 | 4.72e-01 | -0.1526 |
2767 | GNA11 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.42e-14 | 6.29e-01 | -0.1464 |
2767 | GNA11 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.04e-03 | 3.09e-01 | -0.1001 |
2767 | GNA11 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.77e-06 | 4.71e-01 | -0.059 |
2767 | GNA11 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.17e-03 | 6.03e-01 | -0.1706 |
2767 | GNA11 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.09e-08 | 7.18e-01 | -0.2061 |
2767 | GNA11 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.68e-03 | 1.93e-01 | 0.0674 |
2767 | GNA11 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.06e-02 | 1.11e-01 | 0.3859 |
2767 | GNA11 | A002-C-205 | Human | Colorectum | FAP | 2.69e-02 | -1.87e-01 | -0.1236 |
2767 | GNA11 | LZE20T | Human | Esophagus | ESCC | 1.21e-04 | 6.57e-02 | 0.0662 |
2767 | GNA11 | LZE24T | Human | Esophagus | ESCC | 1.60e-07 | 1.30e-01 | 0.0596 |
2767 | GNA11 | P2T-E | Human | Esophagus | ESCC | 2.56e-12 | 4.84e-03 | 0.1177 |
2767 | GNA11 | P4T-E | Human | Esophagus | ESCC | 8.45e-13 | 3.42e-02 | 0.1323 |
2767 | GNA11 | P5T-E | Human | Esophagus | ESCC | 1.10e-06 | -6.57e-02 | 0.1327 |
2767 | GNA11 | P8T-E | Human | Esophagus | ESCC | 1.06e-20 | 1.94e-01 | 0.0889 |
2767 | GNA11 | P9T-E | Human | Esophagus | ESCC | 1.93e-04 | 9.80e-02 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000762319 | Esophagus | ESCC | circadian rhythm | 119/8552 | 210/18723 | 8.47e-04 | 4.36e-03 | 119 |
GO:00434731 | Esophagus | ESCC | pigmentation | 59/8552 | 98/18723 | 2.64e-03 | 1.12e-02 | 59 |
GO:00427529 | Esophagus | ESCC | regulation of circadian rhythm | 68/8552 | 121/18723 | 1.27e-02 | 4.21e-02 | 68 |
GO:007121421 | Liver | HCC | cellular response to abiotic stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:010400421 | Liver | HCC | cellular response to environmental stimulus | 183/7958 | 331/18723 | 1.59e-06 | 2.26e-05 | 183 |
GO:000762321 | Liver | HCC | circadian rhythm | 117/7958 | 210/18723 | 7.29e-05 | 6.54e-04 | 117 |
GO:004851121 | Liver | HCC | rhythmic process | 156/7958 | 298/18723 | 3.54e-04 | 2.46e-03 | 156 |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
GO:004275211 | Liver | HCC | regulation of circadian rhythm | 65/7958 | 121/18723 | 8.25e-03 | 3.24e-02 | 65 |
GO:007121416 | Oral cavity | OSCC | cellular response to abiotic stimulus | 186/7305 | 331/18723 | 1.38e-10 | 4.10e-09 | 186 |
GO:010400416 | Oral cavity | OSCC | cellular response to environmental stimulus | 186/7305 | 331/18723 | 1.38e-10 | 4.10e-09 | 186 |
GO:000931416 | Oral cavity | OSCC | response to radiation | 241/7305 | 456/18723 | 9.76e-10 | 2.40e-08 | 241 |
GO:004851116 | Oral cavity | OSCC | rhythmic process | 157/7305 | 298/18723 | 1.00e-06 | 1.36e-05 | 157 |
GO:000762316 | Oral cavity | OSCC | circadian rhythm | 110/7305 | 210/18723 | 5.40e-05 | 4.48e-04 | 110 |
GO:00094164 | Oral cavity | OSCC | response to light stimulus | 159/7305 | 320/18723 | 5.98e-05 | 4.92e-04 | 159 |
GO:0009314 | Stomach | GC | response to radiation | 47/1159 | 456/18723 | 4.21e-04 | 6.33e-03 | 47 |
GO:00712144 | Stomach | GC | cellular response to abiotic stimulus | 34/1159 | 331/18723 | 2.62e-03 | 2.45e-02 | 34 |
GO:01040044 | Stomach | GC | cellular response to environmental stimulus | 34/1159 | 331/18723 | 2.62e-03 | 2.45e-02 | 34 |
GO:0009649 | Stomach | GC | entrainment of circadian clock | 7/1159 | 34/18723 | 4.21e-03 | 3.49e-02 | 7 |
GO:00076235 | Stomach | GC | circadian rhythm | 23/1159 | 210/18723 | 5.64e-03 | 4.34e-02 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05170 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa05163 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa04912 | Colorectum | AD | GnRH signaling pathway | 35/2092 | 93/8465 | 3.69e-03 | 1.90e-02 | 1.21e-02 | 35 |
hsa04928 | Colorectum | AD | Parathyroid hormone synthesis, secretion and action | 38/2092 | 106/8465 | 6.60e-03 | 2.77e-02 | 1.76e-02 | 38 |
hsa051701 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa051631 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa049121 | Colorectum | AD | GnRH signaling pathway | 35/2092 | 93/8465 | 3.69e-03 | 1.90e-02 | 1.21e-02 | 35 |
hsa049281 | Colorectum | AD | Parathyroid hormone synthesis, secretion and action | 38/2092 | 106/8465 | 6.60e-03 | 2.77e-02 | 1.76e-02 | 38 |
hsa051702 | Colorectum | SER | Human immunodeficiency virus 1 infection | 58/1580 | 212/8465 | 1.08e-03 | 8.56e-03 | 6.21e-03 | 58 |
hsa049282 | Colorectum | SER | Parathyroid hormone synthesis, secretion and action | 31/1580 | 106/8465 | 5.20e-03 | 3.28e-02 | 2.38e-02 | 31 |
hsa051632 | Colorectum | SER | Human cytomegalovirus infection | 57/1580 | 225/8465 | 7.40e-03 | 3.84e-02 | 2.79e-02 | 57 |
hsa049122 | Colorectum | SER | GnRH signaling pathway | 27/1580 | 93/8465 | 9.68e-03 | 4.72e-02 | 3.43e-02 | 27 |
hsa051703 | Colorectum | SER | Human immunodeficiency virus 1 infection | 58/1580 | 212/8465 | 1.08e-03 | 8.56e-03 | 6.21e-03 | 58 |
hsa049283 | Colorectum | SER | Parathyroid hormone synthesis, secretion and action | 31/1580 | 106/8465 | 5.20e-03 | 3.28e-02 | 2.38e-02 | 31 |
hsa051633 | Colorectum | SER | Human cytomegalovirus infection | 57/1580 | 225/8465 | 7.40e-03 | 3.84e-02 | 2.79e-02 | 57 |
hsa049123 | Colorectum | SER | GnRH signaling pathway | 27/1580 | 93/8465 | 9.68e-03 | 4.72e-02 | 3.43e-02 | 27 |
hsa051634 | Colorectum | MSS | Human cytomegalovirus infection | 74/1875 | 225/8465 | 1.12e-04 | 1.01e-03 | 6.19e-04 | 74 |
hsa051704 | Colorectum | MSS | Human immunodeficiency virus 1 infection | 69/1875 | 212/8465 | 2.66e-04 | 1.98e-03 | 1.21e-03 | 69 |
hsa049124 | Colorectum | MSS | GnRH signaling pathway | 35/1875 | 93/8465 | 4.81e-04 | 3.43e-03 | 2.10e-03 | 35 |
hsa04935 | Colorectum | MSS | Growth hormone synthesis, secretion and action | 42/1875 | 120/8465 | 8.17e-04 | 5.16e-03 | 3.16e-03 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GNA11 | SNV | Missense_Mutation | c.340N>T | p.Arg114Trp | p.R114W | P29992 | protein_coding | tolerated(0.16) | possibly_damaging(0.776) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GNA11 | SNV | Missense_Mutation | c.388A>G | p.Ser130Gly | p.S130G | P29992 | protein_coding | tolerated(0.23) | benign(0.003) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
GNA11 | insertion | Frame_Shift_Ins | novel | c.869_870insAAGGCCC | p.Asp290GlufsTer190 | p.D290Efs*190 | P29992 | protein_coding | TCGA-BH-A0HB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | ||
GNA11 | SNV | Missense_Mutation | c.168N>G | p.Ile56Met | p.I56M | P29992 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
GNA11 | SNV | Missense_Mutation | c.733G>A | p.Glu245Lys | p.E245K | P29992 | protein_coding | tolerated(0.24) | benign(0.339) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
GNA11 | SNV | Missense_Mutation | novel | c.721N>A | p.Glu241Lys | p.E241K | P29992 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-LP-A5U2-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
GNA11 | SNV | Missense_Mutation | novel | c.502G>A | p.Ala168Thr | p.A168T | P29992 | protein_coding | tolerated(0.39) | benign(0.005) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
GNA11 | SNV | Missense_Mutation | rs769503200 | c.691G>A | p.Ala231Thr | p.A231T | P29992 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
GNA11 | SNV | Missense_Mutation | rs775624350 | c.490N>A | p.Val164Ile | p.V164I | P29992 | protein_coding | tolerated(0.25) | benign(0.003) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GNA11 | SNV | Missense_Mutation | c.302N>G | p.Tyr101Cys | p.Y101C | P29992 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2767 | GNA11 | CLINICALLY ACTIONABLE | MEK INHIBITOR PD0325901 | 24141786 | ||
2767 | GNA11 | CLINICALLY ACTIONABLE | AEB071 | SOTRASTAURIN | 24141786,27507190 | |
2767 | GNA11 | CLINICALLY ACTIONABLE | CGM097 | CGM-097 | 27507190 | |
2767 | GNA11 | CLINICALLY ACTIONABLE | SELUMETINIB | SELUMETINIB | 26619011,2549426,22808163,24141786,21083380,21444680,25157968,1328859,22733540 | |
2767 | GNA11 | CLINICALLY ACTIONABLE | CABOZANTINIB | CABOZANTINIB | 28103611 | |
2767 | GNA11 | CLINICALLY ACTIONABLE | SOTRASTAURIN ACETATE | 24141786 | ||
2767 | GNA11 | CLINICALLY ACTIONABLE | MEK162 | BINIMETINIB | 24141786,27507190 | |
2767 | GNA11 | CLINICALLY ACTIONABLE | TAK-733 | TAK-733 | 22515704 | |
2767 | GNA11 | CLINICALLY ACTIONABLE | Everolimus | EVEROLIMUS | 27507190 | |
2767 | GNA11 | CLINICALLY ACTIONABLE | Trametinib | TRAMETINIB | 22733540 |
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