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Gene: GAS6 |
Gene summary for GAS6 |
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Gene information | Species | Human | Gene symbol | GAS6 | Gene ID | 2621 |
Gene name | growth arrest specific 6 | |
Gene Alias | AXLLG | |
Cytomap | 13q34 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q14393 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2621 | GAS6 | AEH-subject1 | Human | Endometrium | AEH | 9.34e-11 | -4.01e-01 | -0.3059 |
2621 | GAS6 | AEH-subject2 | Human | Endometrium | AEH | 1.55e-13 | -3.90e-01 | -0.2525 |
2621 | GAS6 | AEH-subject3 | Human | Endometrium | AEH | 1.47e-02 | -2.80e-01 | -0.2576 |
2621 | GAS6 | AEH-subject4 | Human | Endometrium | AEH | 3.33e-07 | -3.06e-01 | -0.2657 |
2621 | GAS6 | AEH-subject5 | Human | Endometrium | AEH | 1.76e-18 | -4.69e-01 | -0.2953 |
2621 | GAS6 | EEC-subject1 | Human | Endometrium | EEC | 8.69e-23 | -4.84e-01 | -0.2682 |
2621 | GAS6 | EEC-subject2 | Human | Endometrium | EEC | 1.75e-20 | -4.39e-01 | -0.2607 |
2621 | GAS6 | EEC-subject3 | Human | Endometrium | EEC | 4.18e-28 | -4.25e-01 | -0.2525 |
2621 | GAS6 | EEC-subject4 | Human | Endometrium | EEC | 3.64e-08 | -3.49e-01 | -0.2571 |
2621 | GAS6 | EEC-subject5 | Human | Endometrium | EEC | 3.06e-19 | -4.82e-01 | -0.249 |
2621 | GAS6 | GSM5276934 | Human | Endometrium | EEC | 1.09e-03 | -3.01e-01 | -0.0913 |
2621 | GAS6 | GSM5276935 | Human | Endometrium | EEC | 5.54e-16 | -4.70e-01 | -0.123 |
2621 | GAS6 | GSM5276937 | Human | Endometrium | EEC | 2.81e-03 | -2.63e-01 | -0.0897 |
2621 | GAS6 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.92e-27 | -5.43e-01 | -0.1869 |
2621 | GAS6 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.71e-24 | -5.43e-01 | -0.1875 |
2621 | GAS6 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.65e-25 | -5.15e-01 | -0.1883 |
2621 | GAS6 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.93e-30 | -5.08e-01 | -0.1934 |
2621 | GAS6 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.15e-28 | -5.03e-01 | -0.1917 |
2621 | GAS6 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.05e-34 | -5.18e-01 | -0.1916 |
2621 | GAS6 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 6.83e-04 | -2.09e-01 | -0.1269 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004440916 | Endometrium | AEH | entry into host | 38/2100 | 151/18723 | 1.17e-06 | 3.82e-05 | 38 |
GO:00713339 | Endometrium | AEH | cellular response to glucose stimulus | 38/2100 | 151/18723 | 1.17e-06 | 3.82e-05 | 38 |
GO:190165415 | Endometrium | AEH | response to ketone | 45/2100 | 194/18723 | 1.48e-06 | 4.69e-05 | 45 |
GO:00713319 | Endometrium | AEH | cellular response to hexose stimulus | 38/2100 | 153/18723 | 1.65e-06 | 5.13e-05 | 38 |
GO:004259310 | Endometrium | AEH | glucose homeostasis | 55/2100 | 258/18723 | 1.87e-06 | 5.74e-05 | 55 |
GO:003238810 | Endometrium | AEH | positive regulation of intracellular transport | 46/2100 | 202/18723 | 1.96e-06 | 5.93e-05 | 46 |
GO:00713269 | Endometrium | AEH | cellular response to monosaccharide stimulus | 38/2100 | 154/18723 | 1.96e-06 | 5.93e-05 | 38 |
GO:003350010 | Endometrium | AEH | carbohydrate homeostasis | 55/2100 | 259/18723 | 2.12e-06 | 6.31e-05 | 55 |
GO:005254716 | Endometrium | AEH | regulation of peptidase activity | 85/2100 | 461/18723 | 2.47e-06 | 7.11e-05 | 85 |
GO:00323869 | Endometrium | AEH | regulation of intracellular transport | 66/2100 | 337/18723 | 4.18e-06 | 1.10e-04 | 66 |
GO:00903168 | Endometrium | AEH | positive regulation of intracellular protein transport | 38/2100 | 160/18723 | 5.22e-06 | 1.33e-04 | 38 |
GO:00434105 | Endometrium | AEH | positive regulation of MAPK cascade | 84/2100 | 480/18723 | 2.19e-05 | 4.25e-04 | 84 |
GO:005254816 | Endometrium | AEH | regulation of endopeptidase activity | 76/2100 | 432/18723 | 4.42e-05 | 7.43e-04 | 76 |
GO:004328116 | Endometrium | AEH | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 43/2100 | 209/18723 | 5.77e-05 | 9.10e-04 | 43 |
GO:00310997 | Endometrium | AEH | regeneration | 41/2100 | 198/18723 | 7.29e-05 | 1.11e-03 | 41 |
GO:004586116 | Endometrium | AEH | negative regulation of proteolysis | 63/2100 | 351/18723 | 1.07e-04 | 1.53e-03 | 63 |
GO:00066117 | Endometrium | AEH | protein export from nucleus | 17/2100 | 57/18723 | 1.13e-04 | 1.60e-03 | 17 |
GO:200011616 | Endometrium | AEH | regulation of cysteine-type endopeptidase activity | 46/2100 | 235/18723 | 1.14e-04 | 1.62e-03 | 46 |
GO:00518974 | Endometrium | AEH | positive regulation of protein kinase B signaling | 28/2100 | 120/18723 | 1.20e-04 | 1.67e-03 | 28 |
GO:00075967 | Endometrium | AEH | blood coagulation | 43/2100 | 217/18723 | 1.42e-04 | 1.89e-03 | 43 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0152110 | Esophagus | ESCC | EGFR tyrosine kinase inhibitor resistance | 55/4205 | 79/8465 | 2.44e-04 | 8.78e-04 | 4.50e-04 | 55 |
hsa0152115 | Esophagus | ESCC | EGFR tyrosine kinase inhibitor resistance | 55/4205 | 79/8465 | 2.44e-04 | 8.78e-04 | 4.50e-04 | 55 |
hsa015219 | Oral cavity | OSCC | EGFR tyrosine kinase inhibitor resistance | 54/3704 | 79/8465 | 8.11e-06 | 3.72e-05 | 1.89e-05 | 54 |
hsa0152114 | Oral cavity | OSCC | EGFR tyrosine kinase inhibitor resistance | 54/3704 | 79/8465 | 8.11e-06 | 3.72e-05 | 1.89e-05 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
GAS6 | AXL | GAS6_AXL | GAS | Breast | ADJ |
GAS6 | AXL | GAS6_AXL | GAS | Breast | DCIS |
GAS6 | MERTK | GAS6_MERTK | GAS | Breast | DCIS |
GAS6 | AXL | GAS6_AXL | GAS | Breast | Healthy |
GAS6 | AXL | GAS6_AXL | GAS | Breast | IDC |
GAS6 | AXL | GAS6_AXL | GAS | Breast | Precancer |
GAS6 | AXL | GAS6_AXL | GAS | Cervix | ADJ |
GAS6 | AXL | GAS6_AXL | GAS | Cervix | CC |
GAS6 | MERTK | GAS6_MERTK | GAS | Cervix | CC |
GAS6 | AXL | GAS6_AXL | GAS | Cervix | Healthy |
GAS6 | AXL | GAS6_AXL | GAS | Cervix | Precancer |
GAS6 | AXL | GAS6_AXL | GAS | CRC | AD |
GAS6 | MERTK | GAS6_MERTK | GAS | CRC | AD |
GAS6 | AXL | GAS6_AXL | GAS | CRC | ADJ |
GAS6 | MERTK | GAS6_MERTK | GAS | CRC | ADJ |
GAS6 | AXL | GAS6_AXL | GAS | CRC | CRC |
GAS6 | MERTK | GAS6_MERTK | GAS | CRC | CRC |
GAS6 | AXL | GAS6_AXL | GAS | CRC | MSI-H |
GAS6 | MERTK | GAS6_MERTK | GAS | CRC | MSI-H |
GAS6 | AXL | GAS6_AXL | GAS | CRC | MSS |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GAS6 | SNV | Missense_Mutation | c.870N>C | p.Lys290Asn | p.K290N | Q14393 | protein_coding | deleterious(0) | possibly_damaging(0.769) | TCGA-C8-A132-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GAS6 | SNV | Missense_Mutation | rs146140804 | c.1211N>T | p.Ala404Val | p.A404V | Q14393 | protein_coding | tolerated(0.99) | benign(0.277) | TCGA-E2-A1IH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD |
GAS6 | SNV | Missense_Mutation | rs748222907 | c.337N>A | p.Val113Met | p.V113M | Q14393 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-GM-A4E0-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
GAS6 | deletion | Frame_Shift_Del | c.449delG | p.Gly150AlafsTer49 | p.G150Afs*49 | Q14393 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
GAS6 | insertion | Frame_Shift_Ins | rs773341392 | c.449_450insG | p.Arg151ProfsTer27 | p.R151Pfs*27 | Q14393 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GAS6 | SNV | Missense_Mutation | novel | c.1921C>T | p.Arg641Cys | p.R641C | Q14393 | protein_coding | deleterious(0.01) | possibly_damaging(0.786) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GAS6 | SNV | Missense_Mutation | novel | c.1297C>A | p.Leu433Ile | p.L433I | Q14393 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GAS6 | SNV | Missense_Mutation | rs771931132 | c.1163C>T | p.Ala388Val | p.A388V | Q14393 | protein_coding | deleterious(0.01) | benign(0.045) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GAS6 | SNV | Missense_Mutation | c.302N>G | p.Ser101Cys | p.S101C | Q14393 | protein_coding | deleterious(0.03) | possibly_damaging(0.642) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
GAS6 | SNV | Missense_Mutation | c.803T>A | p.Leu268His | p.L268H | Q14393 | protein_coding | tolerated(0.13) | probably_damaging(0.912) | TCGA-EA-A5O9-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2621 | GAS6 | DRUG RESISTANCE, DRUGGABLE GENOME, KINASE | WARFARIN | WARFARIN | 16014032 | |
2621 | GAS6 | DRUG RESISTANCE, DRUGGABLE GENOME, KINASE | DOCETAXEL | DOCETAXEL | 27153245 |
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