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Gene: FOXQ1 |
Gene summary for FOXQ1 |
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Gene information | Species | Human | Gene symbol | FOXQ1 | Gene ID | 94234 |
Gene name | forkhead box Q1 | |
Gene Alias | HFH1 | |
Cytomap | 6p25.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9C009 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
94234 | FOXQ1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.83e-02 | 1.03e-01 | 0.0155 |
94234 | FOXQ1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.27e-05 | 3.19e-01 | -0.0811 |
94234 | FOXQ1 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.65e-07 | 3.05e-01 | -0.1088 |
94234 | FOXQ1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.63e-07 | 2.38e-01 | -0.059 |
94234 | FOXQ1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.85e-21 | 5.18e-01 | 0.096 |
94234 | FOXQ1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.52e-05 | 2.67e-01 | 0.0338 |
94234 | FOXQ1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.80e-25 | 5.74e-01 | 0.0674 |
94234 | FOXQ1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.17e-23 | 7.43e-01 | 0.0588 |
94234 | FOXQ1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.38e-30 | 6.68e-01 | 0.294 |
94234 | FOXQ1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.59e-37 | 7.65e-01 | 0.3859 |
94234 | FOXQ1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.27e-19 | 6.07e-01 | 0.2585 |
94234 | FOXQ1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.10e-25 | 6.41e-01 | 0.3005 |
94234 | FOXQ1 | A002-C-203 | Human | Colorectum | FAP | 1.82e-03 | 1.81e-01 | 0.2786 |
94234 | FOXQ1 | CRC-1-8810 | Human | Colorectum | CRC | 7.63e-19 | 4.97e-01 | 0.6257 |
94234 | FOXQ1 | CRC-3-11773 | Human | Colorectum | CRC | 2.00e-05 | 2.59e-01 | 0.2564 |
94234 | FOXQ1 | HCC1 | Human | Liver | HCC | 9.01e-25 | 6.22e+00 | 0.5336 |
94234 | FOXQ1 | HCC2 | Human | Liver | HCC | 2.50e-06 | 1.84e+00 | 0.5341 |
94234 | FOXQ1 | S014 | Human | Liver | HCC | 9.97e-44 | 1.52e+00 | 0.2254 |
94234 | FOXQ1 | S015 | Human | Liver | HCC | 4.77e-33 | 1.61e+00 | 0.2375 |
94234 | FOXQ1 | S016 | Human | Liver | HCC | 2.10e-33 | 1.18e+00 | 0.2243 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00709975 | Colorectum | CRC | neuron death | 65/2078 | 361/18723 | 5.55e-05 | 1.26e-03 | 65 |
GO:19012154 | Colorectum | CRC | negative regulation of neuron death | 41/2078 | 208/18723 | 1.79e-04 | 3.17e-03 | 41 |
GO:19012145 | Colorectum | CRC | regulation of neuron death | 57/2078 | 319/18723 | 1.90e-04 | 3.30e-03 | 57 |
GO:00085442 | Colorectum | CRC | epidermis development | 57/2078 | 324/18723 | 2.88e-04 | 4.59e-03 | 57 |
GO:00514025 | Colorectum | CRC | neuron apoptotic process | 45/2078 | 246/18723 | 5.12e-04 | 7.21e-03 | 45 |
GO:00435881 | Colorectum | CRC | skin development | 47/2078 | 263/18723 | 6.63e-04 | 8.74e-03 | 47 |
GO:00435234 | Colorectum | CRC | regulation of neuron apoptotic process | 38/2078 | 212/18723 | 1.95e-03 | 1.96e-02 | 38 |
GO:00435241 | Colorectum | CRC | negative regulation of neuron apoptotic process | 28/2078 | 145/18723 | 2.43e-03 | 2.30e-02 | 28 |
GO:00224041 | Colorectum | CRC | molting cycle process | 18/2078 | 84/18723 | 4.43e-03 | 3.47e-02 | 18 |
GO:00224051 | Colorectum | CRC | hair cycle process | 18/2078 | 84/18723 | 4.43e-03 | 3.47e-02 | 18 |
GO:0042303 | Colorectum | CRC | molting cycle | 21/2078 | 107/18723 | 6.56e-03 | 4.70e-02 | 21 |
GO:0042633 | Colorectum | CRC | hair cycle | 21/2078 | 107/18723 | 6.56e-03 | 4.70e-02 | 21 |
GO:007099722 | Liver | HCC | neuron death | 202/7958 | 361/18723 | 1.44e-07 | 2.70e-06 | 202 |
GO:190121412 | Liver | HCC | regulation of neuron death | 179/7958 | 319/18723 | 5.65e-07 | 9.01e-06 | 179 |
GO:005140212 | Liver | HCC | neuron apoptotic process | 135/7958 | 246/18723 | 5.64e-05 | 5.26e-04 | 135 |
GO:004352312 | Liver | HCC | regulation of neuron apoptotic process | 117/7958 | 212/18723 | 1.25e-04 | 1.03e-03 | 117 |
GO:190121512 | Liver | HCC | negative regulation of neuron death | 113/7958 | 208/18723 | 3.68e-04 | 2.54e-03 | 113 |
GO:004358817 | Skin | SCCIS | skin development | 36/919 | 263/18723 | 2.51e-08 | 6.66e-06 | 36 |
GO:000854418 | Skin | SCCIS | epidermis development | 40/919 | 324/18723 | 7.81e-08 | 1.15e-05 | 40 |
GO:0070997112 | Skin | SCCIS | neuron death | 34/919 | 361/18723 | 2.20e-04 | 4.09e-03 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOXQ1 | SNV | Missense_Mutation | c.373N>C | p.Ile125Leu | p.I125L | Q9C009 | protein_coding | deleterious(0.02) | possibly_damaging(0.761) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FOXQ1 | SNV | Missense_Mutation | novel | c.582N>C | p.Trp194Cys | p.W194C | Q9C009 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-ZJ-AAXA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FOXQ1 | deletion | Frame_Shift_Del | novel | c.363delC | p.Tyr122ThrfsTer19 | p.Y122Tfs*19 | Q9C009 | protein_coding | TCGA-EA-A5ZE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | ||
FOXQ1 | SNV | Missense_Mutation | rs770819384 | c.463T>C | p.Phe155Leu | p.F155L | Q9C009 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
FOXQ1 | SNV | Missense_Mutation | novel | c.242N>T | p.Ala81Val | p.A81V | Q9C009 | protein_coding | tolerated(0.06) | benign(0) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FOXQ1 | SNV | Missense_Mutation | novel | c.376N>A | p.Ala126Thr | p.A126T | Q9C009 | protein_coding | deleterious(0.01) | probably_damaging(0.934) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FOXQ1 | SNV | Missense_Mutation | novel | c.56A>G | p.Asp19Gly | p.D19G | Q9C009 | protein_coding | deleterious(0) | possibly_damaging(0.587) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
FOXQ1 | SNV | Missense_Mutation | novel | c.430G>A | p.Glu144Lys | p.E144K | Q9C009 | protein_coding | deleterious(0.02) | possibly_damaging(0.46) | TCGA-91-7771-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
FOXQ1 | SNV | Missense_Mutation | c.542N>C | p.Leu181Pro | p.L181P | Q9C009 | protein_coding | tolerated(0.28) | possibly_damaging(0.518) | TCGA-97-8177-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | alimta | SD | |
FOXQ1 | SNV | Missense_Mutation | novel | c.435N>G | p.Ile145Met | p.I145M | Q9C009 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-56-8626-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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