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Gene: FEZ2 |
Gene summary for FEZ2 |
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Gene information | Species | Human | Gene symbol | FEZ2 | Gene ID | 9637 |
Gene name | fasciculation and elongation protein zeta 2 | |
Gene Alias | HUM3CL | |
Cytomap | 2p22.2 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q9UHY8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9637 | FEZ2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.06e-22 | -6.76e-01 | 0.0155 |
9637 | FEZ2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.23e-07 | -5.65e-01 | -0.1808 |
9637 | FEZ2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.41e-07 | -6.14e-01 | -0.1207 |
9637 | FEZ2 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.10e-16 | -4.97e-01 | -0.1464 |
9637 | FEZ2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.95e-10 | -4.51e-01 | -0.1001 |
9637 | FEZ2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.03e-10 | -5.48e-01 | -0.059 |
9637 | FEZ2 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.22e-02 | -5.22e-01 | -0.0842 |
9637 | FEZ2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.78e-09 | -5.54e-01 | 0.096 |
9637 | FEZ2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.41e-02 | -5.97e-01 | 0.0528 |
9637 | FEZ2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.27e-06 | -5.53e-01 | 0.0338 |
9637 | FEZ2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.37e-12 | -4.68e-01 | 0.0674 |
9637 | FEZ2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.80e-03 | -5.18e-01 | 0.0588 |
9637 | FEZ2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.63e-12 | -4.60e-01 | 0.294 |
9637 | FEZ2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.26e-02 | -4.38e-01 | 0.281 |
9637 | FEZ2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.75e-14 | -5.06e-01 | 0.3859 |
9637 | FEZ2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.47e-05 | -6.26e-01 | 0.2585 |
9637 | FEZ2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.46e-21 | -6.03e-01 | 0.3005 |
9637 | FEZ2 | A001-C-207 | Human | Colorectum | FAP | 4.30e-02 | -1.52e-01 | 0.1278 |
9637 | FEZ2 | A015-C-203 | Human | Colorectum | FAP | 1.77e-26 | -3.95e-01 | -0.1294 |
9637 | FEZ2 | A015-C-204 | Human | Colorectum | FAP | 2.13e-03 | -1.81e-01 | -0.0228 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00162411 | Colorectum | SER | regulation of macroautophagy | 34/2897 | 141/18723 | 4.74e-03 | 3.72e-02 | 34 |
GO:00074091 | Colorectum | SER | axonogenesis | 84/2897 | 418/18723 | 6.20e-03 | 4.49e-02 | 84 |
GO:00313302 | Colorectum | MSS | negative regulation of cellular catabolic process | 96/3467 | 262/18723 | 2.67e-12 | 4.63e-10 | 96 |
GO:00098952 | Colorectum | MSS | negative regulation of catabolic process | 110/3467 | 320/18723 | 7.88e-12 | 1.20e-09 | 110 |
GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
GO:00105062 | Colorectum | MSS | regulation of autophagy | 95/3467 | 317/18723 | 4.36e-07 | 1.71e-05 | 95 |
GO:00106392 | Colorectum | MSS | negative regulation of organelle organization | 102/3467 | 348/18723 | 5.36e-07 | 2.05e-05 | 102 |
GO:00162412 | Colorectum | MSS | regulation of macroautophagy | 44/3467 | 141/18723 | 1.88e-04 | 2.64e-03 | 44 |
GO:00074092 | Colorectum | MSS | axonogenesis | 105/3467 | 418/18723 | 4.32e-04 | 5.23e-03 | 105 |
GO:00615642 | Colorectum | MSS | axon development | 115/3467 | 467/18723 | 5.33e-04 | 6.00e-03 | 115 |
GO:00070331 | Colorectum | MSS | vacuole organization | 48/3467 | 180/18723 | 4.32e-03 | 3.07e-02 | 48 |
GO:00105071 | Colorectum | MSS | negative regulation of autophagy | 26/3467 | 85/18723 | 4.84e-03 | 3.38e-02 | 26 |
GO:00098954 | Colorectum | FAP | negative regulation of catabolic process | 91/2622 | 320/18723 | 9.66e-12 | 4.96e-09 | 91 |
GO:00313304 | Colorectum | FAP | negative regulation of cellular catabolic process | 77/2622 | 262/18723 | 6.79e-11 | 2.31e-08 | 77 |
GO:00105063 | Colorectum | FAP | regulation of autophagy | 80/2622 | 317/18723 | 6.43e-08 | 4.54e-06 | 80 |
GO:00615643 | Colorectum | FAP | axon development | 106/2622 | 467/18723 | 1.98e-07 | 1.21e-05 | 106 |
GO:00074093 | Colorectum | FAP | axonogenesis | 97/2622 | 418/18723 | 2.20e-07 | 1.30e-05 | 97 |
GO:00162363 | Colorectum | FAP | macroautophagy | 70/2622 | 291/18723 | 2.73e-06 | 1.02e-04 | 70 |
GO:00106393 | Colorectum | FAP | negative regulation of organelle organization | 80/2622 | 348/18723 | 3.62e-06 | 1.27e-04 | 80 |
GO:00162413 | Colorectum | FAP | regulation of macroautophagy | 38/2622 | 141/18723 | 3.78e-05 | 8.13e-04 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FEZ2 | deletion | Frame_Shift_Del | novel | c.389delT | p.Leu130CysfsTer11 | p.L130Cfs*11 | Q9UHY8 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
FEZ2 | SNV | Missense_Mutation | novel | c.737N>A | p.Arg246Gln | p.R246Q | Q9UHY8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EK-A2RM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FEZ2 | deletion | In_Frame_Del | novel | c.837_839delGAA | p.Lys282del | p.K282del | Q9UHY8 | protein_coding | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
FEZ2 | SNV | Missense_Mutation | c.633G>T | p.Glu211Asp | p.E211D | Q9UHY8 | protein_coding | tolerated(0.33) | benign(0.02) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FEZ2 | SNV | Missense_Mutation | rs781733221 | c.899N>A | p.Gly300Asp | p.G300D | Q9UHY8 | protein_coding | tolerated(0.34) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
FEZ2 | SNV | Missense_Mutation | c.894N>A | p.Met298Ile | p.M298I | Q9UHY8 | protein_coding | tolerated(0.12) | benign(0.169) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FEZ2 | SNV | Missense_Mutation | c.853N>C | p.Asn285His | p.N285H | Q9UHY8 | protein_coding | deleterious(0.03) | possibly_damaging(0.632) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FEZ2 | SNV | Missense_Mutation | c.516G>A | p.Met172Ile | p.M172I | Q9UHY8 | protein_coding | tolerated(0.05) | benign(0.058) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
FEZ2 | insertion | In_Frame_Ins | novel | c.514_515insCTATACATT | p.Met172delinsThrIleHisLeu | p.M172delinsTIHL | Q9UHY8 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FEZ2 | deletion | Frame_Shift_Del | c.1019delN | p.Asn340ThrfsTer12 | p.N340Tfs*12 | Q9UHY8 | protein_coding | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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