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Gene: FBLIM1 |
Gene summary for FBLIM1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | FBLIM1 | Gene ID | 54751 |
Gene name | filamin binding LIM protein 1 | |
Gene Alias | CAL | |
Cytomap | 1p36.21 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q8WUP2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54751 | FBLIM1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.78e-07 | 7.35e-01 | -0.1808 |
54751 | FBLIM1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.72e-15 | 7.13e-01 | -0.1954 |
54751 | FBLIM1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.49e-03 | 1.01e+00 | -0.2602 |
54751 | FBLIM1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.28e-02 | 7.89e-01 | -0.2196 |
54751 | FBLIM1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.77e-03 | 6.15e-01 | -0.1526 |
54751 | FBLIM1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.17e-16 | 8.87e-01 | -0.1464 |
54751 | FBLIM1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.55e-05 | 4.45e-01 | -0.1001 |
54751 | FBLIM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.61e-02 | 5.32e-01 | -0.059 |
54751 | FBLIM1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.14e-02 | 5.88e-01 | -0.0842 |
54751 | FBLIM1 | F007 | Human | Colorectum | FAP | 3.73e-03 | -3.19e-01 | 0.1176 |
54751 | FBLIM1 | A002-C-010 | Human | Colorectum | FAP | 1.15e-02 | -2.60e-01 | 0.242 |
54751 | FBLIM1 | A015-C-203 | Human | Colorectum | FAP | 5.94e-19 | -2.69e-01 | -0.1294 |
54751 | FBLIM1 | A015-C-204 | Human | Colorectum | FAP | 1.37e-02 | -1.42e-01 | -0.0228 |
54751 | FBLIM1 | A002-C-201 | Human | Colorectum | FAP | 6.52e-08 | -2.85e-01 | 0.0324 |
54751 | FBLIM1 | A002-C-203 | Human | Colorectum | FAP | 2.17e-07 | -3.00e-01 | 0.2786 |
54751 | FBLIM1 | A001-C-119 | Human | Colorectum | FAP | 6.85e-05 | -2.93e-01 | -0.1557 |
54751 | FBLIM1 | A001-C-108 | Human | Colorectum | FAP | 2.74e-13 | -3.05e-01 | -0.0272 |
54751 | FBLIM1 | A002-C-205 | Human | Colorectum | FAP | 1.45e-15 | -3.28e-01 | -0.1236 |
54751 | FBLIM1 | A015-C-005 | Human | Colorectum | FAP | 2.63e-05 | -2.46e-01 | -0.0336 |
54751 | FBLIM1 | A015-C-006 | Human | Colorectum | FAP | 3.63e-10 | -4.02e-01 | -0.0994 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000836022 | Liver | HCC | regulation of cell shape | 92/7958 | 154/18723 | 1.15e-05 | 1.31e-04 | 92 |
GO:004325420 | Oral cavity | OSCC | regulation of protein-containing complex assembly | 255/7305 | 428/18723 | 2.94e-18 | 3.15e-16 | 255 |
GO:002260419 | Oral cavity | OSCC | regulation of cell morphogenesis | 163/7305 | 309/18723 | 5.66e-07 | 8.19e-06 | 163 |
GO:000836016 | Oral cavity | OSCC | regulation of cell shape | 88/7305 | 154/18723 | 3.73e-06 | 4.42e-05 | 88 |
GO:0043254110 | Oral cavity | LP | regulation of protein-containing complex assembly | 163/4623 | 428/18723 | 3.72e-10 | 1.92e-08 | 163 |
GO:0022604110 | Oral cavity | LP | regulation of cell morphogenesis | 101/4623 | 309/18723 | 8.65e-04 | 7.50e-03 | 101 |
GO:000836017 | Oral cavity | LP | regulation of cell shape | 53/4623 | 154/18723 | 4.22e-03 | 2.70e-02 | 53 |
GO:004325429 | Skin | cSCC | regulation of protein-containing complex assembly | 167/4864 | 428/18723 | 1.60e-09 | 5.97e-08 | 167 |
GO:002260427 | Skin | cSCC | regulation of cell morphogenesis | 114/4864 | 309/18723 | 1.34e-05 | 1.68e-04 | 114 |
GO:000836025 | Skin | cSCC | regulation of cell shape | 57/4864 | 154/18723 | 1.61e-03 | 9.90e-03 | 57 |
GO:00432546 | Stomach | GC | regulation of protein-containing complex assembly | 58/1159 | 428/18723 | 1.48e-08 | 1.32e-06 | 58 |
GO:00226046 | Stomach | GC | regulation of cell morphogenesis | 44/1159 | 309/18723 | 2.01e-07 | 1.11e-05 | 44 |
GO:00083605 | Stomach | GC | regulation of cell shape | 23/1159 | 154/18723 | 7.52e-05 | 1.63e-03 | 23 |
GO:004325411 | Stomach | CAG with IM | regulation of protein-containing complex assembly | 56/1050 | 428/18723 | 2.91e-09 | 3.23e-07 | 56 |
GO:002260411 | Stomach | CAG with IM | regulation of cell morphogenesis | 41/1050 | 309/18723 | 2.63e-07 | 1.61e-05 | 41 |
GO:000836011 | Stomach | CAG with IM | regulation of cell shape | 22/1050 | 154/18723 | 4.94e-05 | 1.27e-03 | 22 |
GO:004325421 | Stomach | CSG | regulation of protein-containing complex assembly | 56/1034 | 428/18723 | 1.67e-09 | 2.16e-07 | 56 |
GO:002260421 | Stomach | CSG | regulation of cell morphogenesis | 40/1034 | 309/18723 | 4.76e-07 | 2.77e-05 | 40 |
GO:000836021 | Stomach | CSG | regulation of cell shape | 22/1034 | 154/18723 | 3.93e-05 | 1.04e-03 | 22 |
GO:0043254113 | Thyroid | PTC | regulation of protein-containing complex assembly | 215/5968 | 428/18723 | 1.23e-15 | 9.09e-14 | 215 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBLIM1 | SNV | Missense_Mutation | c.145N>G | p.Met49Val | p.M49V | Q8WUP2 | protein_coding | tolerated(0.31) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
FBLIM1 | SNV | Missense_Mutation | c.992C>G | p.Ser331Cys | p.S331C | Q8WUP2 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.924) | TCGA-C8-A12K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FBLIM1 | SNV | Missense_Mutation | rs145692215 | c.32C>T | p.Ser11Leu | p.S11L | Q8WUP2 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FBLIM1 | SNV | Missense_Mutation | c.962G>T | p.Ser321Ile | p.S321I | Q8WUP2 | protein_coding | deleterious(0.01) | benign(0.003) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
FBLIM1 | SNV | Missense_Mutation | c.722N>A | p.Cys241Tyr | p.C241Y | Q8WUP2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FBLIM1 | insertion | Frame_Shift_Ins | novel | c.1094_1095insCT | p.Arg366Ter | p.R366* | Q8WUP2 | protein_coding | TCGA-AA-A02Y-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
FBLIM1 | SNV | Missense_Mutation | novel | c.817N>A | p.Ala273Thr | p.A273T | Q8WUP2 | protein_coding | deleterious(0.03) | possibly_damaging(0.844) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBLIM1 | SNV | Missense_Mutation | rs750253844 | c.112C>T | p.Arg38Trp | p.R38W | Q8WUP2 | protein_coding | tolerated(0.11) | benign(0.005) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FBLIM1 | SNV | Missense_Mutation | novel | c.727N>G | p.Ile243Val | p.I243V | Q8WUP2 | protein_coding | tolerated(1) | benign(0.003) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FBLIM1 | SNV | Missense_Mutation | novel | c.158N>G | p.Glu53Gly | p.E53G | Q8WUP2 | protein_coding | tolerated(1) | benign(0) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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