Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/FASTKD1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/FASTKD1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/FASTKD1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/FASTKD1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00434882 | Colorectum | MSS | regulation of mRNA stability | 62/3467 | 158/18723 | 8.41e-10 | 6.81e-08 | 62 |
GO:00194392 | Colorectum | MSS | aromatic compound catabolic process | 140/3467 | 467/18723 | 8.56e-10 | 6.85e-08 | 140 |
GO:19033114 | Colorectum | FAP | regulation of mRNA metabolic process | 97/2622 | 288/18723 | 1.35e-17 | 4.13e-14 | 97 |
GO:00610134 | Colorectum | FAP | regulation of mRNA catabolic process | 54/2622 | 166/18723 | 8.64e-10 | 1.96e-07 | 54 |
GO:00064024 | Colorectum | FAP | mRNA catabolic process | 68/2622 | 232/18723 | 9.87e-10 | 2.16e-07 | 68 |
GO:00064014 | Colorectum | FAP | RNA catabolic process | 77/2622 | 278/18723 | 1.42e-09 | 2.77e-07 | 77 |
GO:00434874 | Colorectum | FAP | regulation of RNA stability | 53/2622 | 170/18723 | 6.61e-09 | 1.00e-06 | 53 |
GO:00434884 | Colorectum | FAP | regulation of mRNA stability | 50/2622 | 158/18723 | 1.01e-08 | 1.27e-06 | 50 |
GO:00442704 | Colorectum | FAP | cellular nitrogen compound catabolic process | 101/2622 | 451/18723 | 7.42e-07 | 3.44e-05 | 101 |
GO:00346554 | Colorectum | FAP | nucleobase-containing compound catabolic process | 92/2622 | 407/18723 | 1.50e-06 | 6.49e-05 | 92 |
GO:00467004 | Colorectum | FAP | heterocycle catabolic process | 98/2622 | 445/18723 | 2.36e-06 | 9.21e-05 | 98 |
GO:00194394 | Colorectum | FAP | aromatic compound catabolic process | 100/2622 | 467/18723 | 6.75e-06 | 2.08e-04 | 100 |
GO:19013614 | Colorectum | FAP | organic cyclic compound catabolic process | 101/2622 | 495/18723 | 4.87e-05 | 9.93e-04 | 101 |
GO:19033115 | Colorectum | CRC | regulation of mRNA metabolic process | 80/2078 | 288/18723 | 3.21e-15 | 6.40e-12 | 80 |
GO:00064025 | Colorectum | CRC | mRNA catabolic process | 58/2078 | 232/18723 | 1.77e-09 | 5.31e-07 | 58 |
GO:00610135 | Colorectum | CRC | regulation of mRNA catabolic process | 45/2078 | 166/18723 | 8.14e-09 | 1.85e-06 | 45 |
GO:00064015 | Colorectum | CRC | RNA catabolic process | 63/2078 | 278/18723 | 2.21e-08 | 3.23e-06 | 63 |
GO:00434885 | Colorectum | CRC | regulation of mRNA stability | 40/2078 | 158/18723 | 3.96e-07 | 3.21e-05 | 40 |
GO:00434875 | Colorectum | CRC | regulation of RNA stability | 41/2078 | 170/18723 | 1.13e-06 | 6.69e-05 | 41 |
GO:00346555 | Colorectum | CRC | nucleobase-containing compound catabolic process | 73/2078 | 407/18723 | 2.28e-05 | 6.57e-04 | 73 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FASTKD1 | SNV | Missense_Mutation | novel | c.966N>T | p.Lys322Asn | p.K322N | Q53R41 | protein_coding | deleterious(0.02) | possibly_damaging(0.776) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FASTKD1 | SNV | Missense_Mutation | | c.2168C>G | p.Thr723Arg | p.T723R | Q53R41 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FASTKD1 | SNV | Missense_Mutation | | c.1285C>G | p.Pro429Ala | p.P429A | Q53R41 | protein_coding | tolerated(0.26) | benign(0.006) | TCGA-AN-A0AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FASTKD1 | SNV | Missense_Mutation | | c.2031N>C | p.Gln677His | p.Q677H | Q53R41 | protein_coding | tolerated(0.23) | benign(0.41) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
FASTKD1 | SNV | Missense_Mutation | | c.90A>T | p.Gln30His | p.Q30H | Q53R41 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-EW-A1PB-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FASTKD1 | insertion | In_Frame_Ins | novel | c.1032_1033insACGAAAGTTAAACTCCAT | p.Val344_Leu345insThrLysValLysLeuHis | p.V344_L345insTKVKLH | Q53R41 | protein_coding | | | TCGA-B6-A0I6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
FASTKD1 | SNV | Missense_Mutation | | c.142N>C | p.Asp48His | p.D48H | Q53R41 | protein_coding | tolerated(0.38) | benign(0.025) | TCGA-C5-A7CL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
FASTKD1 | SNV | Missense_Mutation | novel | c.404N>C | p.Leu135Pro | p.L135P | Q53R41 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A7UE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
FASTKD1 | SNV | Missense_Mutation | rs758111477 | c.1970N>C | p.Arg657Thr | p.R657T | Q53R41 | protein_coding | tolerated(0.07) | benign(0.175) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FASTKD1 | SNV | Missense_Mutation | novel | c.336N>A | p.Met112Ile | p.M112I | Q53R41 | protein_coding | deleterious(0) | benign(0.238) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |