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Gene: ENG |
Gene summary for ENG |
Gene summary. |
Gene information | Species | Human | Gene symbol | ENG | Gene ID | 2022 |
Gene name | endoglin | |
Gene Alias | END | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P17813 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2022 | ENG | P2T-E | Human | Esophagus | ESCC | 3.59e-14 | 2.65e-01 | 0.1177 |
2022 | ENG | P4T-E | Human | Esophagus | ESCC | 3.79e-03 | 2.74e-01 | 0.1323 |
2022 | ENG | P8T-E | Human | Esophagus | ESCC | 1.95e-04 | 2.27e-01 | 0.0889 |
2022 | ENG | P9T-E | Human | Esophagus | ESCC | 1.61e-03 | 5.56e-01 | 0.1131 |
2022 | ENG | P11T-E | Human | Esophagus | ESCC | 4.66e-09 | 5.38e-01 | 0.1426 |
2022 | ENG | P16T-E | Human | Esophagus | ESCC | 1.34e-04 | 1.20e-01 | 0.1153 |
2022 | ENG | P19T-E | Human | Esophagus | ESCC | 1.02e-07 | 1.32e+00 | 0.1662 |
2022 | ENG | P23T-E | Human | Esophagus | ESCC | 1.07e-02 | 6.68e-01 | 0.108 |
2022 | ENG | P24T-E | Human | Esophagus | ESCC | 1.54e-11 | 6.48e-01 | 0.1287 |
2022 | ENG | P32T-E | Human | Esophagus | ESCC | 1.11e-05 | 6.31e-01 | 0.1666 |
2022 | ENG | P36T-E | Human | Esophagus | ESCC | 4.07e-02 | 6.81e-01 | 0.1187 |
2022 | ENG | P42T-E | Human | Esophagus | ESCC | 2.99e-04 | 5.52e-01 | 0.1175 |
2022 | ENG | P44T-E | Human | Esophagus | ESCC | 7.94e-06 | 4.45e-01 | 0.1096 |
2022 | ENG | P75T-E | Human | Esophagus | ESCC | 4.72e-11 | 2.31e-01 | 0.1125 |
2022 | ENG | P76T-E | Human | Esophagus | ESCC | 5.05e-10 | 1.57e-01 | 0.1207 |
2022 | ENG | P79T-E | Human | Esophagus | ESCC | 8.55e-04 | 2.62e-01 | 0.1154 |
2022 | ENG | P80T-E | Human | Esophagus | ESCC | 1.93e-07 | 4.01e-01 | 0.155 |
2022 | ENG | P130T-E | Human | Esophagus | ESCC | 1.46e-03 | 1.23e-01 | 0.1676 |
2022 | ENG | C07 | Human | Oral cavity | OSCC | 1.05e-02 | 7.07e-01 | 0.2491 |
2022 | ENG | EOLP-1 | Human | Oral cavity | EOLP | 3.43e-03 | 1.13e-01 | -0.0202 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00301984 | Esophagus | ESCC | extracellular matrix organization | 171/8552 | 301/18723 | 6.08e-05 | 4.67e-04 | 171 |
GO:00430624 | Esophagus | ESCC | extracellular structure organization | 171/8552 | 302/18723 | 7.73e-05 | 5.76e-04 | 171 |
GO:00452294 | Esophagus | ESCC | external encapsulating structure organization | 172/8552 | 304/18723 | 7.80e-05 | 5.80e-04 | 172 |
GO:00712606 | Esophagus | ESCC | cellular response to mechanical stimulus | 54/8552 | 81/18723 | 1.09e-04 | 7.64e-04 | 54 |
GO:00018378 | Esophagus | ESCC | epithelial to mesenchymal transition | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:000717810 | Esophagus | ESCC | transmembrane receptor protein serine/threonine kinase signaling pathway | 195/8552 | 355/18723 | 2.58e-04 | 1.58e-03 | 195 |
GO:000961216 | Esophagus | ESCC | response to mechanical stimulus | 124/8552 | 216/18723 | 3.30e-04 | 1.94e-03 | 124 |
GO:00487628 | Esophagus | ESCC | mesenchymal cell differentiation | 133/8552 | 236/18723 | 5.94e-04 | 3.22e-03 | 133 |
GO:00485687 | Esophagus | ESCC | embryonic organ development | 228/8552 | 427/18723 | 7.28e-04 | 3.79e-03 | 228 |
GO:00107174 | Esophagus | ESCC | regulation of epithelial to mesenchymal transition | 61/8552 | 99/18723 | 1.01e-03 | 5.09e-03 | 61 |
GO:00603485 | Esophagus | ESCC | bone development | 115/8552 | 205/18723 | 1.67e-03 | 7.72e-03 | 115 |
GO:00170156 | Esophagus | ESCC | regulation of transforming growth factor beta receptor signaling pathway | 75/8552 | 128/18723 | 2.19e-03 | 9.71e-03 | 75 |
GO:003196020 | Esophagus | ESCC | response to corticosteroid | 95/8552 | 167/18723 | 2.27e-03 | 9.99e-03 | 95 |
GO:00329631 | Esophagus | ESCC | collagen metabolic process | 62/8552 | 104/18723 | 2.90e-03 | 1.22e-02 | 62 |
GO:19038447 | Esophagus | ESCC | regulation of cellular response to transforming growth factor beta stimulus | 76/8552 | 131/18723 | 2.96e-03 | 1.24e-02 | 76 |
GO:00319521 | Esophagus | ESCC | regulation of protein autophosphorylation | 29/8552 | 43/18723 | 3.25e-03 | 1.35e-02 | 29 |
GO:00604856 | Esophagus | ESCC | mesenchyme development | 156/8552 | 291/18723 | 3.76e-03 | 1.53e-02 | 156 |
GO:006053716 | Esophagus | ESCC | muscle tissue development | 211/8552 | 403/18723 | 3.84e-03 | 1.56e-02 | 211 |
GO:00065173 | Esophagus | ESCC | protein deglycosylation | 19/8552 | 26/18723 | 4.31e-03 | 1.71e-02 | 19 |
GO:00970841 | Esophagus | ESCC | vascular associated smooth muscle cell development | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENG | SNV | Missense_Mutation | c.1123N>A | p.Glu375Lys | p.E375K | P17813 | protein_coding | tolerated(0.25) | benign(0.001) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response | |
ENG | SNV | Missense_Mutation | c.95N>C | p.Leu32Pro | p.L32P | P17813 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A8FZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ENG | SNV | Missense_Mutation | rs199675436 | c.121N>A | p.Glu41Lys | p.E41K | P17813 | protein_coding | tolerated(0.73) | benign(0.006) | TCGA-C8-A12M-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ENG | deletion | Frame_Shift_Del | novel | c.1166delN | p.Phe389SerfsTer32 | p.F389Sfs*32 | P17813 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ENG | SNV | Missense_Mutation | c.1678N>G | p.Gln560Glu | p.Q560E | P17813 | protein_coding | tolerated(0.62) | benign(0.149) | TCGA-PN-A8MA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
ENG | SNV | Missense_Mutation | rs143054595 | c.1133N>T | p.Ala378Val | p.A378V | P17813 | protein_coding | tolerated(0.22) | benign(0.245) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ENG | SNV | Missense_Mutation | c.189N>C | p.Glu63Asp | p.E63D | P17813 | protein_coding | deleterious(0.02) | benign(0.011) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ENG | SNV | Missense_Mutation | c.852G>T | p.Glu284Asp | p.E284D | P17813 | protein_coding | tolerated(0.37) | benign(0.003) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ENG | SNV | Missense_Mutation | rs761827492 | c.727G>A | p.Ala243Thr | p.A243T | P17813 | protein_coding | tolerated(0.73) | benign(0.001) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ENG | SNV | Missense_Mutation | c.176N>T | p.Asn59Ile | p.N59I | P17813 | protein_coding | deleterious(0.01) | possibly_damaging(0.641) | TCGA-CM-4744-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2022 | ENG | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | antibody | 315661183 | CAROTUXIMAB | |
2022 | ENG | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | inhibitor | CHEMBL2109321 | CAROTUXIMAB | |
2022 | ENG | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | TRC105 | |||
2022 | ENG | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | TRC105 |
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