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Gene: EMC9 |
Gene summary for EMC9 |
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Gene information | Species | Human | Gene symbol | EMC9 | Gene ID | 51016 |
Gene name | ER membrane protein complex subunit 9 | |
Gene Alias | C14orf122 | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | H0YNH6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51016 | EMC9 | LZE2T | Human | Esophagus | ESCC | 3.94e-07 | 6.31e-01 | 0.082 |
51016 | EMC9 | LZE4T | Human | Esophagus | ESCC | 2.45e-09 | 2.69e-01 | 0.0811 |
51016 | EMC9 | LZE7T | Human | Esophagus | ESCC | 1.40e-08 | 3.62e-01 | 0.0667 |
51016 | EMC9 | LZE24T | Human | Esophagus | ESCC | 8.36e-16 | 4.12e-01 | 0.0596 |
51016 | EMC9 | LZE21T | Human | Esophagus | ESCC | 2.27e-11 | 4.68e-01 | 0.0655 |
51016 | EMC9 | LZE6T | Human | Esophagus | ESCC | 9.07e-08 | 3.33e-01 | 0.0845 |
51016 | EMC9 | P1T-E | Human | Esophagus | ESCC | 1.09e-04 | 2.01e-01 | 0.0875 |
51016 | EMC9 | P2T-E | Human | Esophagus | ESCC | 2.80e-17 | 3.10e-01 | 0.1177 |
51016 | EMC9 | P4T-E | Human | Esophagus | ESCC | 6.31e-39 | 7.73e-01 | 0.1323 |
51016 | EMC9 | P5T-E | Human | Esophagus | ESCC | 1.18e-29 | 5.79e-01 | 0.1327 |
51016 | EMC9 | P8T-E | Human | Esophagus | ESCC | 4.16e-08 | 2.74e-01 | 0.0889 |
51016 | EMC9 | P9T-E | Human | Esophagus | ESCC | 1.74e-22 | 4.47e-01 | 0.1131 |
51016 | EMC9 | P10T-E | Human | Esophagus | ESCC | 1.42e-29 | 6.18e-01 | 0.116 |
51016 | EMC9 | P11T-E | Human | Esophagus | ESCC | 1.78e-13 | 3.81e-01 | 0.1426 |
51016 | EMC9 | P12T-E | Human | Esophagus | ESCC | 1.98e-44 | 8.90e-01 | 0.1122 |
51016 | EMC9 | P15T-E | Human | Esophagus | ESCC | 1.44e-39 | 8.13e-01 | 0.1149 |
51016 | EMC9 | P16T-E | Human | Esophagus | ESCC | 3.85e-11 | 1.66e-01 | 0.1153 |
51016 | EMC9 | P17T-E | Human | Esophagus | ESCC | 1.45e-12 | 4.08e-01 | 0.1278 |
51016 | EMC9 | P19T-E | Human | Esophagus | ESCC | 1.65e-10 | 4.98e-01 | 0.1662 |
51016 | EMC9 | P20T-E | Human | Esophagus | ESCC | 3.75e-11 | 2.58e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00450484 | Skin | cSCC | protein insertion into ER membrane | 16/4864 | 22/18723 | 5.92e-06 | 8.44e-05 | 16 |
GO:00070296 | Skin | cSCC | endoplasmic reticulum organization | 42/4864 | 87/18723 | 6.36e-06 | 8.92e-05 | 42 |
GO:00718164 | Skin | cSCC | tail-anchored membrane protein insertion into ER membrane | 13/4864 | 17/18723 | 1.92e-05 | 2.27e-04 | 13 |
GO:00450504 | Skin | cSCC | protein insertion into ER membrane by stop-transfer membrane-anchor sequence | 9/4864 | 10/18723 | 4.11e-05 | 4.34e-04 | 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EMC9 | SNV | Missense_Mutation | c.39N>C | p.Lys13Asn | p.K13N | Q9Y3B6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
EMC9 | SNV | Missense_Mutation | novel | c.393N>G | p.Ile131Met | p.I131M | Q9Y3B6 | protein_coding | tolerated(0.22) | probably_damaging(0.982) | TCGA-BH-A0E2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
EMC9 | SNV | Missense_Mutation | c.271N>G | p.Gln91Glu | p.Q91E | Q9Y3B6 | protein_coding | tolerated(0.7) | benign(0.062) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EMC9 | insertion | Nonsense_Mutation | novel | c.466_467insGTCCACATCCCCTGGTGGCTCTTGCACCACCGTAGCAGAGCC | p.Ser156delinsCysProHisProLeuValAlaLeuAlaProProTerGlnSerPro | p.S156delinsCPHPLVALAPP*QSP | Q9Y3B6 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
EMC9 | insertion | Frame_Shift_Ins | novel | c.126_127insAACCAGCGGCTCAACACTCAAATCACCCAGTGGGTTGGTCCCA | p.Leu43AsnfsTer82 | p.L43Nfs*82 | Q9Y3B6 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EMC9 | insertion | Nonsense_Mutation | novel | c.394_395insGTTGGTCCCACTAATGGAA | p.Val132GlyfsTer5 | p.V132Gfs*5 | Q9Y3B6 | protein_coding | TCGA-BH-A0E2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | ||
EMC9 | SNV | Missense_Mutation | c.454N>A | p.Asp152Asn | p.D152N | Q9Y3B6 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-C5-A1M6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
EMC9 | SNV | Missense_Mutation | c.121N>A | p.Leu41Met | p.L41M | Q9Y3B6 | protein_coding | deleterious(0.04) | probably_damaging(0.925) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EMC9 | SNV | Missense_Mutation | c.566N>T | p.Gln189Leu | p.Q189L | Q9Y3B6 | protein_coding | tolerated(0.1) | possibly_damaging(0.673) | TCGA-G5-6233-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
EMC9 | SNV | Missense_Mutation | rs779202856 | c.499N>T | p.Arg167Trp | p.R167W | Q9Y3B6 | protein_coding | deleterious(0) | possibly_damaging(0.636) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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