GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00328721 | Colorectum | MSS | regulation of stress-activated MAPK cascade | 51/3467 | 192/18723 | 3.65e-03 | 2.69e-02 | 51 |
GO:00487324 | Colorectum | FAP | gland development | 103/2622 | 436/18723 | 3.61e-08 | 3.12e-06 | 103 |
GO:00310983 | Colorectum | FAP | stress-activated protein kinase signaling cascade | 61/2622 | 247/18723 | 4.79e-06 | 1.57e-04 | 61 |
GO:00514033 | Colorectum | FAP | stress-activated MAPK cascade | 59/2622 | 239/18723 | 6.90e-06 | 2.11e-04 | 59 |
GO:00226123 | Colorectum | FAP | gland morphogenesis | 34/2622 | 118/18723 | 2.13e-05 | 5.12e-04 | 34 |
GO:00703022 | Colorectum | FAP | regulation of stress-activated protein kinase signaling cascade | 48/2622 | 195/18723 | 5.14e-05 | 1.04e-03 | 48 |
GO:00328722 | Colorectum | FAP | regulation of stress-activated MAPK cascade | 47/2622 | 192/18723 | 7.08e-05 | 1.32e-03 | 47 |
GO:00351482 | Colorectum | FAP | tube formation | 38/2622 | 148/18723 | 1.17e-04 | 1.91e-03 | 38 |
GO:00431222 | Colorectum | FAP | regulation of I-kappaB kinase/NF-kappaB signaling | 56/2622 | 249/18723 | 1.82e-04 | 2.69e-03 | 56 |
GO:0043588 | Colorectum | FAP | skin development | 58/2622 | 263/18723 | 2.44e-04 | 3.39e-03 | 58 |
GO:0007254 | Colorectum | FAP | JNK cascade | 39/2622 | 167/18723 | 7.60e-04 | 8.07e-03 | 39 |
GO:00085441 | Colorectum | FAP | epidermis development | 66/2622 | 324/18723 | 9.63e-04 | 9.51e-03 | 66 |
GO:00431232 | Colorectum | FAP | positive regulation of I-kappaB kinase/NF-kappaB signaling | 42/2622 | 186/18723 | 1.01e-03 | 9.89e-03 | 42 |
GO:0046328 | Colorectum | FAP | regulation of JNK cascade | 32/2622 | 133/18723 | 1.28e-03 | 1.19e-02 | 32 |
GO:0070304 | Colorectum | FAP | positive regulation of stress-activated protein kinase signaling cascade | 31/2622 | 128/18723 | 1.35e-03 | 1.24e-02 | 31 |
GO:00072492 | Colorectum | FAP | I-kappaB kinase/NF-kappaB signaling | 58/2622 | 281/18723 | 1.37e-03 | 1.24e-02 | 58 |
GO:0032874 | Colorectum | FAP | positive regulation of stress-activated MAPK cascade | 30/2622 | 126/18723 | 2.13e-03 | 1.76e-02 | 30 |
GO:0022404 | Colorectum | FAP | molting cycle process | 21/2622 | 84/18723 | 5.10e-03 | 3.37e-02 | 21 |
GO:0022405 | Colorectum | FAP | hair cycle process | 21/2622 | 84/18723 | 5.10e-03 | 3.37e-02 | 21 |
GO:00487325 | Colorectum | CRC | gland development | 88/2078 | 436/18723 | 1.62e-08 | 2.79e-06 | 88 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EDA | SNV | Missense_Mutation | novel | c.550C>A | p.Pro184Thr | p.P184T | Q92838 | protein_coding | tolerated_low_confidence(0.14) | probably_damaging(0.998) | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
EDA | SNV | Missense_Mutation | | c.408G>T | p.Leu136Phe | p.L136F | Q92838 | protein_coding | deleterious_low_confidence(0.01) | benign(0.047) | TCGA-A8-A08F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
EDA | SNV | Missense_Mutation | rs132630312 | c.463C>T | p.Arg155Cys | p.R155C | Q92838 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EDA | SNV | Missense_Mutation | | c.353N>T | p.Pro118Leu | p.P118L | Q92838 | protein_coding | tolerated_low_confidence(0.1) | benign(0) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD |
EDA | SNV | Missense_Mutation | novel | c.116N>A | p.Ser39Asn | p.S39N | Q92838 | protein_coding | tolerated_low_confidence(0.19) | benign(0.003) | TCGA-EA-A439-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
EDA | SNV | Missense_Mutation | novel | c.397N>G | p.Met133Val | p.M133V | Q92838 | protein_coding | tolerated_low_confidence(0.4) | benign(0) | TCGA-ZJ-AAXJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EDA | SNV | Missense_Mutation | | c.796N>A | p.Leu266Ile | p.L266I | Q92838 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.979) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EDA | SNV | Missense_Mutation | | c.929N>G | p.Tyr310Cys | p.Y310C | Q92838 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.995) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EDA | SNV | Missense_Mutation | novel | c.476N>T | p.Arg159Ile | p.R159I | Q92838 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.944) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EDA | SNV | Missense_Mutation | | c.497C>T | p.Ala166Val | p.A166V | Q92838 | protein_coding | tolerated_low_confidence(0.07) | benign(0.085) | TCGA-CI-6624-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |