![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DUSP6 |
Gene summary for DUSP6 |
![]() |
Gene information | Species | Human | Gene symbol | DUSP6 | Gene ID | 1848 |
Gene name | dual specificity phosphatase 6 | |
Gene Alias | HH19 | |
Cytomap | 12q21.33 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024RBC1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1848 | DUSP6 | CA_HPV_1 | Human | Cervix | CC | 1.26e-05 | -1.84e-01 | 0.0264 |
1848 | DUSP6 | CA_HPV_3 | Human | Cervix | CC | 3.22e-04 | -3.08e-01 | 0.0414 |
1848 | DUSP6 | CCI_1 | Human | Cervix | CC | 1.94e-05 | -5.26e-01 | 0.528 |
1848 | DUSP6 | CCI_2 | Human | Cervix | CC | 7.14e-05 | -5.26e-01 | 0.5249 |
1848 | DUSP6 | CCI_3 | Human | Cervix | CC | 2.22e-05 | -5.10e-01 | 0.516 |
1848 | DUSP6 | CCII_1 | Human | Cervix | CC | 9.71e-07 | -4.92e-01 | 0.3249 |
1848 | DUSP6 | Tumor | Human | Cervix | CC | 7.83e-11 | -3.76e-01 | 0.1241 |
1848 | DUSP6 | sample3 | Human | Cervix | CC | 7.10e-08 | -3.26e-01 | 0.1387 |
1848 | DUSP6 | L1 | Human | Cervix | CC | 2.33e-10 | -4.96e-01 | 0.0802 |
1848 | DUSP6 | T3 | Human | Cervix | CC | 4.84e-06 | -3.16e-01 | 0.1389 |
1848 | DUSP6 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.30e-03 | 1.83e-01 | -0.1954 |
1848 | DUSP6 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.80e-21 | 5.94e-01 | 0.294 |
1848 | DUSP6 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.86e-04 | 9.57e-01 | 0.3487 |
1848 | DUSP6 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.93e-05 | 2.86e-01 | 0.3859 |
1848 | DUSP6 | LZE8T | Human | Esophagus | ESCC | 3.40e-02 | -4.32e-01 | 0.067 |
1848 | DUSP6 | LZE20T | Human | Esophagus | ESCC | 2.29e-08 | -5.52e-01 | 0.0662 |
1848 | DUSP6 | LZE22D1 | Human | Esophagus | HGIN | 2.64e-05 | -6.15e-01 | 0.0595 |
1848 | DUSP6 | LZE24T | Human | Esophagus | ESCC | 3.71e-13 | -5.96e-01 | 0.0596 |
1848 | DUSP6 | P2T-E | Human | Esophagus | ESCC | 1.55e-50 | 1.95e+00 | 0.1177 |
1848 | DUSP6 | P8T-E | Human | Esophagus | ESCC | 3.25e-03 | 2.87e-01 | 0.0889 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00105632 | Colorectum | MSS | negative regulation of phosphorus metabolic process | 118/3467 | 442/18723 | 1.18e-05 | 2.77e-04 | 118 |
GO:00459362 | Colorectum | MSS | negative regulation of phosphate metabolic process | 117/3467 | 441/18723 | 1.74e-05 | 3.84e-04 | 117 |
GO:00423262 | Colorectum | MSS | negative regulation of phosphorylation | 103/3467 | 385/18723 | 3.76e-05 | 7.17e-04 | 103 |
GO:00019332 | Colorectum | MSS | negative regulation of protein phosphorylation | 93/3467 | 342/18723 | 4.54e-05 | 8.35e-04 | 93 |
GO:00486381 | Colorectum | MSS | regulation of developmental growth | 84/3467 | 330/18723 | 1.01e-03 | 1.01e-02 | 84 |
GO:00064702 | Colorectum | MSS | protein dephosphorylation | 73/3467 | 281/18723 | 1.15e-03 | 1.12e-02 | 73 |
GO:00434092 | Colorectum | MSS | negative regulation of MAPK cascade | 50/3467 | 180/18723 | 1.45e-03 | 1.35e-02 | 50 |
GO:00163112 | Colorectum | MSS | dephosphorylation | 101/3467 | 417/18723 | 1.98e-03 | 1.70e-02 | 101 |
GO:00094101 | Colorectum | MSS | response to xenobiotic stimulus | 110/3467 | 462/18723 | 2.36e-03 | 1.92e-02 | 110 |
GO:00459363 | Colorectum | MSI-H | negative regulation of phosphate metabolic process | 53/1319 | 441/18723 | 9.54e-05 | 3.01e-03 | 53 |
GO:00105633 | Colorectum | MSI-H | negative regulation of phosphorus metabolic process | 53/1319 | 442/18723 | 1.01e-04 | 3.16e-03 | 53 |
GO:00423263 | Colorectum | MSI-H | negative regulation of phosphorylation | 45/1319 | 385/18723 | 5.71e-04 | 1.14e-02 | 45 |
GO:00019333 | Colorectum | MSI-H | negative regulation of protein phosphorylation | 40/1319 | 342/18723 | 1.11e-03 | 1.86e-02 | 40 |
GO:00064703 | Colorectum | MSI-H | protein dephosphorylation | 34/1319 | 281/18723 | 1.43e-03 | 2.22e-02 | 34 |
GO:00434093 | Colorectum | MSI-H | negative regulation of MAPK cascade | 23/1319 | 180/18723 | 4.02e-03 | 4.63e-02 | 23 |
GO:004593626 | Esophagus | HGIN | negative regulation of phosphate metabolic process | 89/2587 | 441/18723 | 1.24e-04 | 2.54e-03 | 89 |
GO:001056326 | Esophagus | HGIN | negative regulation of phosphorus metabolic process | 89/2587 | 442/18723 | 1.34e-04 | 2.71e-03 | 89 |
GO:000647017 | Esophagus | HGIN | protein dephosphorylation | 61/2587 | 281/18723 | 1.86e-04 | 3.51e-03 | 61 |
GO:004232620 | Esophagus | HGIN | negative regulation of phosphorylation | 78/2587 | 385/18723 | 2.77e-04 | 4.77e-03 | 78 |
GO:000193320 | Esophagus | HGIN | negative regulation of protein phosphorylation | 69/2587 | 342/18723 | 6.81e-04 | 9.26e-03 | 69 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa040109 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa0401012 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa052215 | Esophagus | ESCC | Acute myeloid leukemia | 49/4205 | 67/8465 | 7.43e-05 | 3.07e-04 | 1.57e-04 | 49 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0522113 | Esophagus | ESCC | Acute myeloid leukemia | 49/4205 | 67/8465 | 7.43e-05 | 3.07e-04 | 1.57e-04 | 49 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa05221 | Liver | HCC | Acute myeloid leukemia | 41/4020 | 67/8465 | 1.64e-02 | 3.90e-02 | 2.17e-02 | 41 |
hsa052211 | Liver | HCC | Acute myeloid leukemia | 41/4020 | 67/8465 | 1.64e-02 | 3.90e-02 | 2.17e-02 | 41 |
hsa040108 | Lung | IAC | MAPK signaling pathway | 62/1053 | 302/8465 | 3.54e-05 | 6.38e-04 | 4.24e-04 | 62 |
hsa052026 | Lung | IAC | Transcriptional misregulation in cancer | 40/1053 | 193/8465 | 6.90e-04 | 5.90e-03 | 3.92e-03 | 40 |
hsa0401011 | Lung | IAC | MAPK signaling pathway | 62/1053 | 302/8465 | 3.54e-05 | 6.38e-04 | 4.24e-04 | 62 |
hsa0520211 | Lung | IAC | Transcriptional misregulation in cancer | 40/1053 | 193/8465 | 6.90e-04 | 5.90e-03 | 3.92e-03 | 40 |
hsa0401021 | Lung | AIS | MAPK signaling pathway | 57/961 | 302/8465 | 6.41e-05 | 9.43e-04 | 6.03e-04 | 57 |
hsa052022 | Lung | AIS | Transcriptional misregulation in cancer | 39/961 | 193/8465 | 2.15e-04 | 2.41e-03 | 1.54e-03 | 39 |
hsa0401031 | Lung | AIS | MAPK signaling pathway | 57/961 | 302/8465 | 6.41e-05 | 9.43e-04 | 6.03e-04 | 57 |
hsa052023 | Lung | AIS | Transcriptional misregulation in cancer | 39/961 | 193/8465 | 2.15e-04 | 2.41e-03 | 1.54e-03 | 39 |
hsa040106 | Lung | MIAC | MAPK signaling pathway | 32/507 | 302/8465 | 1.12e-03 | 1.36e-02 | 9.81e-03 | 32 |
hsa052024 | Lung | MIAC | Transcriptional misregulation in cancer | 22/507 | 193/8465 | 2.64e-03 | 2.26e-02 | 1.64e-02 | 22 |
hsa052212 | Lung | MIAC | Acute myeloid leukemia | 10/507 | 67/8465 | 6.16e-03 | 4.07e-02 | 2.95e-02 | 10 |
hsa040107 | Lung | MIAC | MAPK signaling pathway | 32/507 | 302/8465 | 1.12e-03 | 1.36e-02 | 9.81e-03 | 32 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DUSP6 | SNV | Missense_Mutation | novel | c.917C>A | p.Ala306Asp | p.A306D | Q16828 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
DUSP6 | SNV | Missense_Mutation | c.73G>A | p.Glu25Lys | p.E25K | Q16828 | protein_coding | tolerated(0.09) | benign(0.067) | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DUSP6 | insertion | Frame_Shift_Ins | novel | c.915_916insATACTCCATTT | p.Ala306IlefsTer15 | p.A306Ifs*15 | Q16828 | protein_coding | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
DUSP6 | insertion | In_Frame_Ins | novel | c.877_878insCTAATC | p.Cys293delinsSerAsnArg | p.C293delinsSNR | Q16828 | protein_coding | TCGA-A8-A082-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
DUSP6 | insertion | Frame_Shift_Ins | novel | c.875_876insAAAAGAAAATTGTGCTCTT | p.His292GlnfsTer13 | p.H292Qfs*13 | Q16828 | protein_coding | TCGA-A8-A082-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
DUSP6 | SNV | Missense_Mutation | novel | c.442N>C | p.Glu148Gln | p.E148Q | Q16828 | protein_coding | tolerated(0.06) | possibly_damaging(0.661) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DUSP6 | SNV | Missense_Mutation | c.93N>A | p.Asn31Lys | p.N31K | Q16828 | protein_coding | tolerated(0.91) | benign(0.007) | TCGA-A6-6648-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD | |
DUSP6 | SNV | Missense_Mutation | novel | c.277N>A | p.Asp93Asn | p.D93N | Q16828 | protein_coding | tolerated(0.5) | benign(0.015) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DUSP6 | SNV | Missense_Mutation | c.911N>T | p.Thr304Ile | p.T304I | Q16828 | protein_coding | deleterious(0.02) | probably_damaging(0.913) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DUSP6 | SNV | Missense_Mutation | c.611N>T | p.Pro204Leu | p.P204L | Q16828 | protein_coding | deleterious(0.01) | possibly_damaging(0.641) | TCGA-G4-6295-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1848 | DUSP6 | DRUGGABLE GENOME, PROTEIN PHOSPHATASE, ENZYME, KINASE | DIMETHYL SULFOXIDE | 10702230 | ||
1848 | DUSP6 | DRUGGABLE GENOME, PROTEIN PHOSPHATASE, ENZYME, KINASE | TRAMETINIB | TRAMETINIB | 22169769 | |
1848 | DUSP6 | DRUGGABLE GENOME, PROTEIN PHOSPHATASE, ENZYME, KINASE | RETINOIC ACID | 11104676 |
Page: 1 |