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Gene: DPY30 |
Gene summary for DPY30 |
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Gene information | Species | Human | Gene symbol | DPY30 | Gene ID | 84661 |
Gene name | dpy-30 histone methyltransferase complex regulatory subunit | |
Gene Alias | Cps25 | |
Cytomap | 2p22.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9C005 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84661 | DPY30 | LZE4T | Human | Esophagus | ESCC | 5.43e-15 | 5.69e-01 | 0.0811 |
84661 | DPY30 | LZE7T | Human | Esophagus | ESCC | 1.72e-12 | 1.08e+00 | 0.0667 |
84661 | DPY30 | LZE8T | Human | Esophagus | ESCC | 7.66e-09 | 3.17e-01 | 0.067 |
84661 | DPY30 | LZE20T | Human | Esophagus | ESCC | 4.06e-05 | 3.24e-01 | 0.0662 |
84661 | DPY30 | LZE22D1 | Human | Esophagus | HGIN | 3.19e-05 | 5.13e-02 | 0.0595 |
84661 | DPY30 | LZE24T | Human | Esophagus | ESCC | 4.81e-18 | 8.29e-01 | 0.0596 |
84661 | DPY30 | LZE21T | Human | Esophagus | ESCC | 1.96e-04 | 5.87e-01 | 0.0655 |
84661 | DPY30 | LZE6T | Human | Esophagus | ESCC | 1.50e-14 | 1.02e+00 | 0.0845 |
84661 | DPY30 | P1T-E | Human | Esophagus | ESCC | 3.03e-06 | 6.90e-01 | 0.0875 |
84661 | DPY30 | P2T-E | Human | Esophagus | ESCC | 3.66e-62 | 1.21e+00 | 0.1177 |
84661 | DPY30 | P4T-E | Human | Esophagus | ESCC | 3.76e-42 | 1.25e+00 | 0.1323 |
84661 | DPY30 | P5T-E | Human | Esophagus | ESCC | 4.78e-46 | 9.07e-01 | 0.1327 |
84661 | DPY30 | P8T-E | Human | Esophagus | ESCC | 7.77e-36 | 8.15e-01 | 0.0889 |
84661 | DPY30 | P9T-E | Human | Esophagus | ESCC | 2.03e-22 | 5.93e-01 | 0.1131 |
84661 | DPY30 | P10T-E | Human | Esophagus | ESCC | 3.24e-46 | 9.47e-01 | 0.116 |
84661 | DPY30 | P11T-E | Human | Esophagus | ESCC | 2.02e-18 | 1.09e+00 | 0.1426 |
84661 | DPY30 | P12T-E | Human | Esophagus | ESCC | 1.48e-38 | 9.05e-01 | 0.1122 |
84661 | DPY30 | P15T-E | Human | Esophagus | ESCC | 8.35e-42 | 1.14e+00 | 0.1149 |
84661 | DPY30 | P16T-E | Human | Esophagus | ESCC | 2.98e-60 | 1.21e+00 | 0.1153 |
84661 | DPY30 | P17T-E | Human | Esophagus | ESCC | 9.89e-09 | 6.39e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064791 | Liver | Cirrhotic | protein methylation | 61/4634 | 181/18723 | 4.13e-03 | 2.21e-02 | 61 |
GO:00082131 | Liver | Cirrhotic | protein alkylation | 61/4634 | 181/18723 | 4.13e-03 | 2.21e-02 | 61 |
GO:00165711 | Liver | Cirrhotic | histone methylation | 49/4634 | 141/18723 | 4.90e-03 | 2.56e-02 | 49 |
GO:001657021 | Liver | HCC | histone modification | 283/7958 | 463/18723 | 2.68e-16 | 2.33e-14 | 283 |
GO:001619721 | Liver | HCC | endosomal transport | 154/7958 | 230/18723 | 4.74e-14 | 2.95e-12 | 154 |
GO:00182052 | Liver | HCC | peptidyl-lysine modification | 230/7958 | 376/18723 | 1.51e-13 | 8.32e-12 | 230 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:00064792 | Liver | HCC | protein methylation | 111/7958 | 181/18723 | 2.36e-07 | 4.18e-06 | 111 |
GO:00082132 | Liver | HCC | protein alkylation | 111/7958 | 181/18723 | 2.36e-07 | 4.18e-06 | 111 |
GO:00165712 | Liver | HCC | histone methylation | 88/7958 | 141/18723 | 1.41e-06 | 2.02e-05 | 88 |
GO:00349681 | Liver | HCC | histone lysine methylation | 70/7958 | 115/18723 | 5.32e-05 | 5.04e-04 | 70 |
GO:00180221 | Liver | HCC | peptidyl-lysine methylation | 74/7958 | 131/18723 | 8.46e-04 | 5.06e-03 | 74 |
GO:0051568 | Liver | HCC | histone H3-K4 methylation | 36/7958 | 59/18723 | 3.15e-03 | 1.46e-02 | 36 |
GO:00165707 | Oral cavity | OSCC | histone modification | 270/7305 | 463/18723 | 1.59e-17 | 1.50e-15 | 270 |
GO:00182056 | Oral cavity | OSCC | peptidyl-lysine modification | 216/7305 | 376/18723 | 2.32e-13 | 1.16e-11 | 216 |
GO:00161979 | Oral cavity | OSCC | endosomal transport | 141/7305 | 230/18723 | 5.40e-12 | 2.06e-10 | 141 |
GO:00064797 | Oral cavity | OSCC | protein methylation | 92/7305 | 181/18723 | 7.86e-04 | 4.26e-03 | 92 |
GO:00082137 | Oral cavity | OSCC | protein alkylation | 92/7305 | 181/18723 | 7.86e-04 | 4.26e-03 | 92 |
GO:00434142 | Oral cavity | OSCC | macromolecule methylation | 149/7305 | 316/18723 | 1.82e-03 | 8.60e-03 | 149 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DPY30 | SNV | Missense_Mutation | c.192N>G | p.Ile64Met | p.I64M | Q9C005 | protein_coding | deleterious(0) | possibly_damaging(0.714) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
DPY30 | SNV | Missense_Mutation | c.86G>A | p.Arg29Lys | p.R29K | Q9C005 | protein_coding | tolerated(0.88) | benign(0.015) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DPY30 | SNV | Missense_Mutation | c.61N>C | p.Tyr21His | p.Y21H | Q9C005 | protein_coding | tolerated(0.3) | benign(0.421) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
DPY30 | SNV | Missense_Mutation | c.86G>A | p.Arg29Lys | p.R29K | Q9C005 | protein_coding | tolerated(0.88) | benign(0.015) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DPY30 | SNV | Missense_Mutation | c.235N>C | p.Asn79His | p.N79H | Q9C005 | protein_coding | deleterious(0) | possibly_damaging(0.701) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
DPY30 | SNV | Missense_Mutation | c.86N>T | p.Arg29Ile | p.R29I | Q9C005 | protein_coding | deleterious(0.01) | possibly_damaging(0.809) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
DPY30 | SNV | Missense_Mutation | c.46N>C | p.Asn16His | p.N16H | Q9C005 | protein_coding | deleterious(0) | possibly_damaging(0.69) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DPY30 | SNV | Missense_Mutation | novel | c.175C>G | p.Gln59Glu | p.Q59E | Q9C005 | protein_coding | deleterious(0.03) | benign(0.033) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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