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Gene: DPH6 |
Gene summary for DPH6 |
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Gene information | Species | Human | Gene symbol | DPH6 | Gene ID | 89978 |
Gene name | diphthamine biosynthesis 6 | |
Gene Alias | ATPBD4 | |
Cytomap | 15q14 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | Q7L8W6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
89978 | DPH6 | CCI_1 | Human | Cervix | CC | 9.59e-08 | 6.78e-01 | 0.528 |
89978 | DPH6 | CCI_3 | Human | Cervix | CC | 1.94e-02 | 5.15e-01 | 0.516 |
89978 | DPH6 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.70e-20 | -7.43e-01 | 0.0155 |
89978 | DPH6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.37e-09 | -7.05e-01 | -0.1808 |
89978 | DPH6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.98e-07 | -7.13e-01 | -0.1207 |
89978 | DPH6 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.48e-03 | -5.47e-01 | -0.1526 |
89978 | DPH6 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.69e-11 | -5.48e-01 | -0.1464 |
89978 | DPH6 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.00e-08 | -5.24e-01 | -0.1001 |
89978 | DPH6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.70e-09 | -5.50e-01 | -0.059 |
89978 | DPH6 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.46e-04 | -7.54e-01 | -0.2061 |
89978 | DPH6 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.50e-06 | -7.25e-01 | -0.0179 |
89978 | DPH6 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.62e-15 | -6.77e-01 | 0.096 |
89978 | DPH6 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.94e-06 | -5.76e-01 | 0.0338 |
89978 | DPH6 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.05e-08 | -4.77e-01 | 0.0674 |
89978 | DPH6 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.09e-08 | -4.61e-01 | 0.294 |
89978 | DPH6 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.87e-25 | -7.41e-01 | 0.3859 |
89978 | DPH6 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.44e-06 | -7.30e-01 | 0.2585 |
89978 | DPH6 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.23e-16 | -6.17e-01 | 0.3005 |
89978 | DPH6 | F007 | Human | Colorectum | FAP | 1.37e-03 | -4.22e-01 | 0.1176 |
89978 | DPH6 | A015-C-203 | Human | Colorectum | FAP | 3.12e-23 | -4.66e-02 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000641717 | Endometrium | EEC | regulation of translation | 94/2168 | 468/18723 | 5.37e-08 | 2.88e-06 | 94 |
GO:000641414 | Endometrium | EEC | translational elongation | 13/2168 | 55/18723 | 8.79e-03 | 4.74e-02 | 13 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
GO:00021817 | Liver | NAFLD | cytoplasmic translation | 93/1882 | 148/18723 | 1.44e-55 | 8.41e-52 | 93 |
GO:00064177 | Liver | NAFLD | regulation of translation | 85/1882 | 468/18723 | 4.58e-08 | 4.54e-06 | 85 |
GO:00064145 | Liver | NAFLD | translational elongation | 16/1882 | 55/18723 | 6.71e-05 | 1.44e-03 | 16 |
GO:000218122 | Liver | HCC | cytoplasmic translation | 132/7958 | 148/18723 | 9.09e-33 | 5.76e-30 | 132 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:000641412 | Liver | HCC | translational elongation | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
GO:00021818 | Lung | IAC | cytoplasmic translation | 85/2061 | 148/18723 | 3.11e-43 | 1.85e-39 | 85 |
GO:00064178 | Lung | IAC | regulation of translation | 86/2061 | 468/18723 | 1.16e-06 | 6.18e-05 | 86 |
GO:000218113 | Lung | AIS | cytoplasmic translation | 85/1849 | 148/18723 | 5.48e-47 | 3.19e-43 | 85 |
GO:000641713 | Lung | AIS | regulation of translation | 78/1849 | 468/18723 | 2.68e-06 | 1.49e-04 | 78 |
GO:000218133 | Lung | MIAC | cytoplasmic translation | 73/967 | 148/18723 | 4.84e-54 | 2.48e-50 | 73 |
GO:000641733 | Lung | MIAC | regulation of translation | 51/967 | 468/18723 | 3.94e-07 | 6.52e-05 | 51 |
GO:00064146 | Lung | MIAC | translational elongation | 10/967 | 55/18723 | 4.52e-04 | 1.25e-02 | 10 |
GO:000218120 | Oral cavity | OSCC | cytoplasmic translation | 133/7305 | 148/18723 | 1.94e-38 | 2.46e-35 | 133 |
GO:000641720 | Oral cavity | OSCC | regulation of translation | 274/7305 | 468/18723 | 4.39e-18 | 4.63e-16 | 274 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DPH6 | SNV | Missense_Mutation | c.274G>A | p.Glu92Lys | p.E92K | Q7L8W6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
DPH6 | insertion | Frame_Shift_Ins | novel | c.770_771insTG | p.Tyr258AlafsTer31 | p.Y258Afs*31 | Q7L8W6 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
DPH6 | SNV | Missense_Mutation | c.431G>T | p.Arg144Ile | p.R144I | Q7L8W6 | protein_coding | deleterious(0) | benign(0.213) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DPH6 | SNV | Missense_Mutation | c.431N>A | p.Arg144Lys | p.R144K | Q7L8W6 | protein_coding | tolerated(0.06) | benign(0.033) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
DPH6 | SNV | Missense_Mutation | novel | c.199N>A | p.Leu67Ile | p.L67I | Q7L8W6 | protein_coding | tolerated(0.05) | benign(0.313) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DPH6 | SNV | Missense_Mutation | c.712N>A | p.Ala238Thr | p.A238T | Q7L8W6 | protein_coding | deleterious(0.03) | benign(0.196) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DPH6 | SNV | Missense_Mutation | novel | c.374G>A | p.Arg125Gln | p.R125Q | Q7L8W6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
DPH6 | SNV | Missense_Mutation | c.177C>A | p.Asp59Glu | p.D59E | Q7L8W6 | protein_coding | tolerated(1) | benign(0.003) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DPH6 | SNV | Missense_Mutation | novel | c.23N>A | p.Ser8Asn | p.S8N | Q7L8W6 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DPH6 | SNV | Missense_Mutation | novel | c.253N>C | p.Tyr85His | p.Y85H | Q7L8W6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EY-A5W2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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