Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: DOCK5

Gene summary for DOCK5

Gene summary.

Gene information	Species	Human
	Gene symbol	DOCK5
	Gene ID	80005
	Gene name	dedicator of cytokinesis 5
	Gene Alias	DOCK5
	Cytomap	8p21.2
	Gene Type	protein-coding
	GO ID	GO:0000902
	UniProtAcc	B9A015

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
80005	DOCK5	HTA11_3410_2000001011	Human	Colorectum	AD	1.40e-19	-6.06e-01	0.0155
80005	DOCK5	HTA11_347_2000001011	Human	Colorectum	AD	1.15e-12	6.09e-01	-0.1954
80005	DOCK5	HTA11_411_2000001011	Human	Colorectum	SER	1.98e-03	7.91e-01	-0.2602
80005	DOCK5	HTA11_866_3004761011	Human	Colorectum	AD	4.24e-10	-4.60e-01	0.096
80005	DOCK5	HTA11_8622_2000001021	Human	Colorectum	SER	1.60e-03	-6.47e-01	0.0528
80005	DOCK5	HTA11_99999970781_79442	Human	Colorectum	MSS	1.21e-05	-3.52e-01	0.294
80005	DOCK5	HTA11_99999965104_69814	Human	Colorectum	MSS	1.84e-09	-5.84e-01	0.281
80005	DOCK5	HTA11_99999971662_82457	Human	Colorectum	MSS	2.06e-17	-5.92e-01	0.3859
80005	DOCK5	HTA11_99999973899_84307	Human	Colorectum	MSS	3.00e-04	-5.32e-01	0.2585
80005	DOCK5	HTA11_99999974143_84620	Human	Colorectum	MSS	3.79e-22	-5.61e-01	0.3005
80005	DOCK5	F007	Human	Colorectum	FAP	2.38e-03	-4.21e-01	0.1176
80005	DOCK5	A015-C-203	Human	Colorectum	FAP	1.63e-36	-5.05e-01	-0.1294
80005	DOCK5	A015-C-204	Human	Colorectum	FAP	6.33e-05	-3.36e-01	-0.0228
80005	DOCK5	A014-C-040	Human	Colorectum	FAP	6.25e-07	-6.59e-01	-0.1184
80005	DOCK5	A002-C-201	Human	Colorectum	FAP	1.17e-13	-3.44e-01	0.0324
80005	DOCK5	A002-C-203	Human	Colorectum	FAP	1.87e-03	-1.56e-01	0.2786
80005	DOCK5	A001-C-119	Human	Colorectum	FAP	2.89e-11	-5.00e-01	-0.1557
80005	DOCK5	A001-C-108	Human	Colorectum	FAP	5.45e-20	-2.92e-01	-0.0272
80005	DOCK5	A002-C-205	Human	Colorectum	FAP	2.48e-24	-4.71e-01	-0.1236
80005	DOCK5	A001-C-104	Human	Colorectum	FAP	2.57e-02	-1.72e-01	0.0184

Page: 1 2 3 4 5 6 7 8

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Colorectum (GSE201348)		FAP: Familial adenomatous polyposis
		CRC: Colorectal cancer
Colorectum (HTA11)		AD: Adenomas
		SER: Sessile serrated lesions
		MSI-H: Microsatellite-high colorectal cancer
		MSS: Microsatellite stable colorectal cancer
Endometrium		AEH: Atypical endometrial hyperplasia
		EEC: Endometrioid Cancer
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
Liver		HCC: Hepatocellular carcinoma
		NAFLD: Non-alcoholic fatty liver disease
Lung		AAH: Atypical adenomatous hyperplasia
		AIS: Adenocarcinoma in situ
		IAC: Invasive lung adenocarcinoma
		MIA: Minimally invasive adenocarcinoma
Oral Cavity		EOLP: Erosive Oral lichen planus
		LP: leukoplakia
		NEOLP: Non-erosive oral lichen planus
		OSCC: Oral squamous cell carcinoma
Prostate		BPH: Benign Prostatic Hyperplasia
Thyroid		ATC: Anaplastic thyroid cancer
		HT: Hashimoto's thyroiditis
		PTC: Papillary thyroid cancer

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:00108111	Colorectum	SER	positive regulation of cell-substrate adhesion	41/2897	123/18723	6.52e-07	3.15e-05	41
GO:00315891	Colorectum	SER	cell-substrate adhesion	86/2897	363/18723	2.36e-05	6.64e-04	86
GO:00107691	Colorectum	SER	regulation of cell morphogenesis involved in differentiation	31/2897	96/18723	2.95e-05	7.89e-04	31
GO:19000241	Colorectum	SER	regulation of substrate adhesion-dependent cell spreading	21/2897	57/18723	6.59e-05	1.51e-03	21
GO:00016671	Colorectum	SER	ameboidal-type cell migration	105/2897	475/18723	6.97e-05	1.59e-03	105
GO:00107701	Colorectum	SER	positive regulation of cell morphogenesis involved in differentiation	26/2897	79/18723	8.81e-05	1.91e-03	26
GO:00344461	Colorectum	SER	substrate adhesion-dependent cell spreading	32/2897	108/18723	1.42e-04	2.82e-03	32
GO:00901321	Colorectum	SER	epithelium migration	82/2897	360/18723	1.50e-04	2.93e-03	82
GO:00106311	Colorectum	SER	epithelial cell migration	81/2897	357/18723	1.87e-04	3.44e-03	81
GO:19000261	Colorectum	SER	positive regulation of substrate adhesion-dependent cell spreading	16/2897	41/18723	2.21e-04	3.89e-03	16
GO:00901301	Colorectum	SER	tissue migration	82/2897	365/18723	2.40e-04	4.12e-03	82
GO:00106321	Colorectum	SER	regulation of epithelial cell migration	68/2897	292/18723	2.72e-04	4.53e-03	68
GO:00902571	Colorectum	SER	regulation of muscle system process	60/2897	252/18723	3.28e-04	5.22e-03	60
GO:00457851	Colorectum	SER	positive regulation of cell adhesion	93/2897	437/18723	6.78e-04	9.04e-03	93
GO:00107201	Colorectum	SER	positive regulation of cell development	66/2897	298/18723	1.36e-03	1.50e-02	66
GO:0003012	Colorectum	SER	muscle system process	92/2897	452/18723	2.98e-03	2.63e-02	92
GO:00106341	Colorectum	SER	positive regulation of epithelial cell migration	41/2897	176/18723	4.03e-03	3.30e-02	41
GO:00226042	Colorectum	MSS	regulation of cell morphogenesis	103/3467	309/18723	2.70e-10	2.56e-08	103
GO:00108102	Colorectum	MSS	regulation of cell-substrate adhesion	73/3467	221/18723	1.56e-07	7.16e-06	73
GO:00108112	Colorectum	MSS	positive regulation of cell-substrate adhesion	47/3467	123/18723	2.28e-07	9.79e-06	47

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

Enriched KEGG pathways.

Pathway ID

Tissue

Disease Stage

Description

Gene Ratio

Bg Ratio

pvalue

p.adjust

qvalue

Count

Page: 1

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

DOCK5

SNV

Missense_Mutation

c.3478N>C

p.Glu1160Gln

p.E1160Q

Q9H7D0

protein_coding

deleterious(0)

probably_damaging(0.987)

TCGA-A2-A0EQ-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

adriamycin

DOCK5

SNV

Missense_Mutation

novel

c.5007N>T

p.Arg1669Ser

p.R1669S

Q9H7D0

protein_coding

tolerated(0.11)

possibly_damaging(0.468)

TCGA-AO-A0J5-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Other, specify in notesBisphosphonate

zoledronic

DOCK5

SNV

Missense_Mutation

c.4037C>G

p.Ala1346Gly

p.A1346G

Q9H7D0

protein_coding

deleterious(0)

possibly_damaging(0.817)

TCGA-AR-A251-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Chemotherapy

doxorubicin

DOCK5

SNV

Missense_Mutation

c.360N>A

p.Met120Ile

p.M120I

Q9H7D0

protein_coding

deleterious(0)

benign(0.14)

TCGA-B6-A0IJ-01

Breast

breast invasive carcinoma

Female

<65

I/II

Unknown

DOCK5

SNV

Missense_Mutation

novel

c.5390N>T

p.Ala1797Val

p.A1797V

Q9H7D0

protein_coding

tolerated(0.11)

benign(0.01)

TCGA-BH-A0EE-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Chemotherapy

docetaxel

DOCK5

SNV

Missense_Mutation

c.1960N>A

p.Leu654Ile

p.L654I

Q9H7D0

protein_coding

deleterious(0)

probably_damaging(0.974)

TCGA-E2-A1IE-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

doxorubicin

DOCK5

SNV

Missense_Mutation

novel

c.2394N>A

p.Phe798Leu

p.F798L

Q9H7D0

protein_coding

tolerated(0.35)

benign(0.001)

TCGA-EW-A3E8-01

Breast

breast invasive carcinoma

Female

<65

I/II

Hormone Therapy

anastrozole

DOCK5

SNV

Missense_Mutation

novel

c.5558C>T

p.Pro1853Leu

p.P1853L

Q9H7D0

protein_coding

tolerated_low_confidence(0.13)

probably_damaging(0.987)

TCGA-OL-A66K-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

DOCK5

insertion

Nonsense_Mutation

novel

c.4501_4502insCACGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAC

p.Trp1501SerfsTer12

p.W1501Sfs*12

Q9H7D0

protein_coding

TCGA-A8-A07U-01

Breast

breast invasive carcinoma

Female

>=65

III/IV

Chemotherapy

5-fluorouracil

DOCK5

insertion

Frame_Shift_Ins

novel

c.5031_5032insCTATCAGTTGCTCATCCACGGAAGTGCCCCAGGACTCCGTTAGA

p.Ser1678LeufsTer77

p.S1678Lfs*77

Q9H7D0

protein_coding

TCGA-B6-A0IK-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Unknown

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1